ID   ATP25_NEUCR             Reviewed;         699 AA.
AC   Q7SAC2;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=ATPase synthesis protein 25, mitochondrial;
DE   Flags: Precursor;
GN   Name=atp25; ORFNames=NCU06309;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Probable mitochondrial mRNA stabilization factor.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATP25 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA33335.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM002239; EAA33335.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_962571.2; XM_957478.2.
DR   PDB; 6YWV; EM; 3.03 A; n=1-699.
DR   PDBsum; 6YWV; -.
DR   AlphaFoldDB; Q7SAC2; -.
DR   SMR; Q7SAC2; -.
DR   STRING; 5141.EFNCRP00000006116; -.
DR   PRIDE; Q7SAC2; -.
DR   EnsemblFungi; EAA33335; EAA33335; NCU06309.
DR   GeneID; 3878705; -.
DR   KEGG; ncr:NCU06309; -.
DR   HOGENOM; CLU_016140_1_0_1; -.
DR   InParanoid; Q7SAC2; -.
DR   OMA; IMIFGTA; -.
DR   Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0140053; P:mitochondrial gene expression; IEA:InterPro.
DR   GO; GO:0033615; P:mitochondrial proton-transporting ATP synthase complex assembly; IBA:GO_Central.
DR   GO; GO:0048255; P:mRNA stabilization; IBA:GO_Central.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR040152; Atp25.
DR   InterPro; IPR043519; NT_sf.
DR   PANTHER; PTHR28087; PTHR28087; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..31
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..699
FT                   /note="ATPase synthesis protein 25, mitochondrial"
FT                   /id="PRO_0000404477"
FT   REGION          46..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   699 AA;  77889 MW;  A92983FFEF6A6167 CRC64;
     MSATPAVLRA SACSACRFSA LRLFVSSFAS PRAPLPVART RVLSPTAPYS TFRPSPRLLA
     SPSSEEHAEP AAQEQPNKTE DAQAEASTEA NNEGGADVPW YLQVDAPTHP TLVHEPPPLP
     DIPEGSPKLM EPLVKFVSDE LGMDDLKLLD LREIDPPPAL GPEVLMLFGT ARSERHLHVS
     ADRLVRWLRN RGVTAKADGL LGRNELKTKL RRKARKAKLL GTTGLPSGAD DGITTGWICV
     NLGTLGWSDM EMEFKDEKGV TSGFGVPQSG TTLVVQLMTE TRREELALEK LWSGILRRSL
     ERQDKIAGKL PEASFTTSPD TVSGQSFSPS PIRSSGRNRK RPDRLYFSTS ARQHAAAVDV
     SQTDLATAMA GWEYSNASPS TIDNLLAQDT DSKVQLLIQM QEYLSSLPRD QALSAVSLCE
     DGSPSTFMRL FNRAIENLPS AQAWEARLWV EKAARALQHP DHDLARLGDL IQEMKLSGAA
     NVSREKFVDL LRMIFAIPET TDAGVRQQAS LSMDVIDMLF SRGEKVIEYD VVVAVIESLL
     QTRARPPEAR RLLSQFEDLL SEAQMDCPTE DEIIRLLDVY ANHRAWDKFW NVWRVFPRHC
     ERRTERMYTK VYERIAAEDH QGMATDALRW CVEEMWHEQP PVRVTAAMLK ALEACIRIAD
     PEAESLAKDI DDRISDAQYM DREFVRLWLT LHGSAAWGA