AAD6_YEAST
ID AAD6_YEAST Reviewed; 212 AA.
AC P43547; D6VTH4; E9P925;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Putative aryl-alcohol dehydrogenase AAD6 {ECO:0000303|PubMed:10581269};
DE EC=1.1.1.-;
GN Name=AAD6 {ECO:0000303|PubMed:10581269};
GN OrderedLocusNames=YFL056C {ECO:0000312|SGD:S000001838};
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP IDENTIFICATION OF FRAMESHIFT.
RX PubMed=10581269; DOI=10.1093/genetics/153.4.1591;
RA Delneri D., Gardner D.C.J., Oliver S.G.;
RT "Analysis of the seven-member AAD gene set demonstrates that genetic
RT redundancy in yeast may be more apparent than real.";
RL Genetics 153:1591-1600(1999).
CC -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC reductase 2 subfamily. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene unlikely to encode a
CC functional protein. This is the N-terminal part of an aryl-alcohol
CC dehydrogenase homolog of the AAD family. In strain S288c, a -1
CC frameshift disrupts the gene coding for this protein and produces two
CC ORFs YFL056C and YFL057C. Because of that it is not part of the
CC S.cerevisiae S288c complete/reference proteome set.
CC {ECO:0000305|PubMed:10581269, ECO:0000305|PubMed:24374639}.
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DR EMBL; D50617; BAA09185.1; -; Genomic_DNA.
DR EMBL; AY693161; AAT93180.1; -; Genomic_DNA.
DR PIR; S56199; S56199.
DR AlphaFoldDB; P43547; -.
DR SMR; P43547; -.
DR BioGRID; 31091; 26.
DR DIP; DIP-2015N; -.
DR IntAct; P43547; 2.
DR MINT; P43547; -.
DR STRING; 4932.YFL056C; -.
DR PaxDb; P43547; -.
DR PRIDE; P43547; -.
DR SGD; S000001838; AAD6.
DR VEuPathDB; FungiDB:YFL056C; -.
DR eggNOG; KOG1575; Eukaryota.
DR HOGENOM; CLU_023205_16_2_1; -.
DR InParanoid; P43547; -.
DR OMA; SHGWIQP; -.
DR GO; GO:0047681; F:aryl-alcohol dehydrogenase (NADP+) activity; ISS:SGD.
DR GO; GO:0006081; P:cellular aldehyde metabolic process; ISS:SGD.
DR Gene3D; 3.20.20.100; -; 1.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR SUPFAM; SSF51430; SSF51430; 1.
PE 5: Uncertain;
KW Oxidoreductase.
FT CHAIN 1..212
FT /note="Putative aryl-alcohol dehydrogenase AAD6"
FT /id="PRO_0000070367"
FT ACT_SITE 76
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT CONFLICT 208
FT /note="V -> K (in Ref. 3; AAT93180)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 212 AA; 23919 MW; C3FF042B12C91580 CRC64;
MADLFAPAPE PSTELGRLRV LSKSAGIRVS PLILGGMSIG DAWSEILGSM SKERAFELLD
AFYEAGGNFI DTANNYQNEQ SEAWIGEWMV SRKLRDQIVI ATKFTTDYKK YDVGGGKSAN
YCGNHKRSLH VSVRDSLRKL QTDWIDILYV HWWDYMSSIE EVMDSLHILV QQARSSIWVC
LIRLPGLFLR QITTLNLMVK PLLASIKVNG TC
