ID   PTH_HUMAN               Reviewed;         214 AA.
AC   Q86Y79;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Probable peptidyl-tRNA hydrolase;
DE            Short=PTH;
DE            EC=3.1.1.29;
GN   Name=PTRH1; Synonyms=C9orf115;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC         amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC         Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC         EC=3.1.1.29;
CC   -!- INTERACTION:
CC       Q86Y79; O15084: ANKRD28; NbExp=3; IntAct=EBI-2602515, EBI-359567;
CC       Q86Y79; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-2602515, EBI-10175124;
CC       Q86Y79; P80188: LCN2; NbExp=3; IntAct=EBI-2602515, EBI-11911016;
CC       Q86Y79; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-2602515, EBI-79165;
CC   -!- SIMILARITY: Belongs to the PTH family. {ECO:0000305}.
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DR   EMBL; BC047012; AAH47012.1; -; mRNA.
DR   CCDS; CCDS35147.1; -.
DR   RefSeq; NP_001002913.1; NM_001002913.2.
DR   AlphaFoldDB; Q86Y79; -.
DR   SMR; Q86Y79; -.
DR   BioGRID; 126512; 22.
DR   IntAct; Q86Y79; 14.
DR   STRING; 9606.ENSP00000418661; -.
DR   iPTMnet; Q86Y79; -.
DR   PhosphoSitePlus; Q86Y79; -.
DR   BioMuta; PTRH1; -.
DR   DMDM; 74750555; -.
DR   EPD; Q86Y79; -.
DR   jPOST; Q86Y79; -.
DR   MassIVE; Q86Y79; -.
DR   MaxQB; Q86Y79; -.
DR   PaxDb; Q86Y79; -.
DR   PeptideAtlas; Q86Y79; -.
DR   PRIDE; Q86Y79; -.
DR   ProteomicsDB; 70381; -.
DR   Antibodypedia; 17102; 109 antibodies from 17 providers.
DR   DNASU; 138428; -.
DR   Ensembl; ENST00000419060.5; ENSP00000418661.1; ENSG00000187024.15.
DR   Ensembl; ENST00000543175.5; ENSP00000439469.1; ENSG00000187024.15.
DR   GeneID; 138428; -.
DR   KEGG; hsa:138428; -.
DR   MANE-Select; ENST00000543175.5; ENSP00000439469.1; NM_001002913.3; NP_001002913.1.
DR   UCSC; uc004bro.4; human.
DR   CTD; 138428; -.
DR   DisGeNET; 138428; -.
DR   GeneCards; PTRH1; -.
DR   HGNC; HGNC:27039; PTRH1.
DR   HPA; ENSG00000187024; Low tissue specificity.
DR   neXtProt; NX_Q86Y79; -.
DR   OpenTargets; ENSG00000187024; -.
DR   PharmGKB; PA134917129; -.
DR   VEuPathDB; HostDB:ENSG00000187024; -.
DR   eggNOG; KOG2255; Eukaryota.
DR   GeneTree; ENSGT00390000004247; -.
DR   InParanoid; Q86Y79; -.
DR   OMA; HVLSKFH; -.
DR   PhylomeDB; Q86Y79; -.
DR   TreeFam; TF332601; -.
DR   PathwayCommons; Q86Y79; -.
DR   SignaLink; Q86Y79; -.
DR   BioGRID-ORCS; 138428; 27 hits in 1078 CRISPR screens.
DR   ChiTaRS; PTRH1; human.
DR   GenomeRNAi; 138428; -.
DR   Pharos; Q86Y79; Tdark.
DR   PRO; PR:Q86Y79; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q86Y79; protein.
DR   Bgee; ENSG00000187024; Expressed in right adrenal gland and 127 other tissues.
DR   ExpressionAtlas; Q86Y79; baseline and differential.
DR   Genevisible; Q86Y79; HS.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR   CDD; cd00462; PTH; 1.
DR   Gene3D; 3.40.50.1470; -; 1.
DR   InterPro; IPR001328; Pept_tRNA_hydro.
DR   InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR   InterPro; IPR036416; Pept_tRNA_hydro_sf.
DR   PANTHER; PTHR17224; PTHR17224; 1.
DR   Pfam; PF01195; Pept_tRNA_hydro; 1.
DR   SUPFAM; SSF53178; SSF53178; 1.
DR   PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..214
FT                   /note="Probable peptidyl-tRNA hydrolase"
FT                   /id="PRO_0000240441"
SQ   SEQUENCE   214 AA;  22937 MW;  DBA3959411DA8248 CRC64;
     MRPGGFLGAG QRLSRAMSRC VLEPRPPGKR WMVAGLGNPG LPGTRHSVGM AVLGQLARRL
     GVAESWTRDR HCAADLALAP LGDAQLVLLR PRRLMNANGR SVARAAELFG LTAEEVYLVH
     DELDKPLGRL ALKLGGSARG HNGVRSCISC LNSNAMPRLR VGIGRPAHPE AVQAHVLGCF
     SPAEQELLPL LLDRATDLIL DHIRERSQGP SLGP