PTH_MOUSE
ID PTH_MOUSE Reviewed; 204 AA.
AC Q8BW00;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Probable peptidyl-tRNA hydrolase;
DE Short=PTH;
DE EC=3.1.1.29;
GN Name=Ptrh1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC EC=3.1.1.29;
CC -!- SIMILARITY: Belongs to the PTH family. {ECO:0000305}.
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DR EMBL; AK075833; BAC35994.1; -; mRNA.
DR EMBL; BC098218; AAH98218.1; -; mRNA.
DR CCDS; CCDS15931.1; -.
DR RefSeq; NP_848710.1; NM_178595.3.
DR AlphaFoldDB; Q8BW00; -.
DR SMR; Q8BW00; -.
DR STRING; 10090.ENSMUSP00000068850; -.
DR iPTMnet; Q8BW00; -.
DR PhosphoSitePlus; Q8BW00; -.
DR EPD; Q8BW00; -.
DR MaxQB; Q8BW00; -.
DR PaxDb; Q8BW00; -.
DR PeptideAtlas; Q8BW00; -.
DR PRIDE; Q8BW00; -.
DR ProteomicsDB; 291627; -.
DR Antibodypedia; 17102; 109 antibodies from 17 providers.
DR Ensembl; ENSMUST00000066352; ENSMUSP00000068850; ENSMUSG00000053746.
DR GeneID; 329384; -.
DR KEGG; mmu:329384; -.
DR UCSC; uc008jgx.1; mouse.
DR CTD; 138428; -.
DR MGI; MGI:1913779; Ptrh1.
DR VEuPathDB; HostDB:ENSMUSG00000053746; -.
DR eggNOG; KOG2255; Eukaryota.
DR GeneTree; ENSGT00390000004247; -.
DR HOGENOM; CLU_062456_2_2_1; -.
DR InParanoid; Q8BW00; -.
DR OMA; HVLSKFH; -.
DR OrthoDB; 1514615at2759; -.
DR PhylomeDB; Q8BW00; -.
DR TreeFam; TF332601; -.
DR BioGRID-ORCS; 329384; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ptrh1; mouse.
DR PRO; PR:Q8BW00; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BW00; protein.
DR Bgee; ENSMUSG00000053746; Expressed in decidua and 143 other tissues.
DR Genevisible; Q8BW00; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IBA:GO_Central.
DR CDD; cd00462; PTH; 1.
DR Gene3D; 3.40.50.1470; -; 1.
DR InterPro; IPR001328; Pept_tRNA_hydro.
DR InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR InterPro; IPR036416; Pept_tRNA_hydro_sf.
DR PANTHER; PTHR17224; PTHR17224; 1.
DR Pfam; PF01195; Pept_tRNA_hydro; 1.
DR SUPFAM; SSF53178; SSF53178; 1.
DR PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..204
FT /note="Probable peptidyl-tRNA hydrolase"
FT /id="PRO_0000240442"
SQ SEQUENCE 204 AA; 22161 MW; EC6ACAEAEB3C3984 CRC64;
MRRSWALSRQ VSEARFPGKR WLVAGLGNHG MPGTRHSVGM AVLGQIARRL GVAENWTRDS
RCAADLALAP LGDAQLVLLR PRRLMNVNGR SVARAAELFG LTAEEIYLVH DELDKPLGKL
ALKLGGSARG HNGVRSCISC LNSNAMPRLL VGIGRPTHPN MVENHVLGCF SPEEQELLSP
LMDQATDLLL DHIRARSQGP LSGL
