ID   PTH_SCHPO               Reviewed;         206 AA.
AC   O74806;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Probable peptidyl-tRNA hydrolase;
DE            Short=PTH;
DE            EC=3.1.1.29;
GN   Name=pth1; ORFNames=SPBC2D10.15c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC         amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC         Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC         EC=3.1.1.29;
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PTH family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21173.2; -; Genomic_DNA.
DR   PIR; T40118; T40118.
DR   RefSeq; NP_596234.2; NM_001022154.3.
DR   AlphaFoldDB; O74806; -.
DR   SMR; O74806; -.
DR   BioGRID; 276869; 6.
DR   STRING; 4896.SPBC2D10.15c.1; -.
DR   MaxQB; O74806; -.
DR   PaxDb; O74806; -.
DR   EnsemblFungi; SPBC2D10.15c.1; SPBC2D10.15c.1:pep; SPBC2D10.15c.
DR   GeneID; 2540340; -.
DR   KEGG; spo:SPBC2D10.15c; -.
DR   PomBase; SPBC2D10.15c; pth1.
DR   VEuPathDB; FungiDB:SPBC2D10.15c; -.
DR   eggNOG; KOG2255; Eukaryota.
DR   HOGENOM; CLU_062456_2_1_1; -.
DR   InParanoid; O74806; -.
DR   OMA; GRCESRS; -.
DR   PhylomeDB; O74806; -.
DR   PRO; PR:O74806; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005759; C:mitochondrial matrix; IC:PomBase.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; ISO:PomBase.
DR   GO; GO:0032543; P:mitochondrial translation; ISO:PomBase.
DR   CDD; cd00462; PTH; 1.
DR   Gene3D; 3.40.50.1470; -; 1.
DR   InterPro; IPR001328; Pept_tRNA_hydro.
DR   InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR   InterPro; IPR036416; Pept_tRNA_hydro_sf.
DR   PANTHER; PTHR17224; PTHR17224; 1.
DR   Pfam; PF01195; Pept_tRNA_hydro; 1.
DR   SUPFAM; SSF53178; SSF53178; 1.
DR   PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Mitochondrion; Reference proteome.
FT   CHAIN           1..206
FT                   /note="Probable peptidyl-tRNA hydrolase"
FT                   /id="PRO_0000187866"
SQ   SEQUENCE   206 AA;  23410 MW;  42FE7E7C009274E5 CRC64;
     MAIKHLPKIL IARKNKAEVN HCDLKRRVSI KIIYGLGNPG SAFVKSRHSL GKLMVSMYAD
     SMAFPKNWPS TKENLTLVLS TSYMNDSGKQ LKKISNDFVR KVSPLDKIVY VVVHDELELD
     LGKVKLRLPG GSHRGHNGIR SCQEFLGKES FYRIGLGIGR CESRNREDVS DYVLSKFNSN
     EMKLIETDIF HKFCNILQQL QLSIET