PTH_STAA8
ID PTH_STAA8 Reviewed; 190 AA.
AC Q2G0R9;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Peptidyl-tRNA hydrolase {ECO:0000255|HAMAP-Rule:MF_00083};
DE Short=PTH {ECO:0000255|HAMAP-Rule:MF_00083};
DE EC=3.1.1.29 {ECO:0000255|HAMAP-Rule:MF_00083};
DE AltName: Full=SaPth {ECO:0000303|PubMed:26508479};
GN Name=pth {ECO:0000255|HAMAP-Rule:MF_00083};
GN OrderedLocusNames=SAOUHSC_00475;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
RN [2] {ECO:0007744|PDB:4YLY}
RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS), AND SUBUNIT.
RC STRAIN=NCTC 8325 / PS 47 {ECO:0000303|PubMed:26508479};
RX PubMed=26508479; DOI=10.1093/abbs/gmv114;
RA Zhang F., Song Y., Niu L., Teng M., Li X.;
RT "Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a
RT 2.25 A resolution.";
RL Acta Biochim. Biophys. Sin. 47:1005-1010(2015).
CC -!- FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs
CC which drop off the ribosome during protein synthesis.
CC {ECO:0000255|HAMAP-Rule:MF_00083}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC EC=3.1.1.29; Evidence={ECO:0000255|HAMAP-Rule:MF_00083};
CC -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00083,
CC ECO:0000269|PubMed:26508479}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00083}.
CC -!- SIMILARITY: Belongs to the PTH family. {ECO:0000255|HAMAP-
CC Rule:MF_00083}.
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DR EMBL; CP000253; ABD29630.1; -; Genomic_DNA.
DR RefSeq; WP_000649791.1; NZ_LS483365.1.
DR RefSeq; YP_499054.1; NC_007795.1.
DR PDB; 4YLY; X-ray; 2.25 A; A/B=1-190.
DR PDBsum; 4YLY; -.
DR AlphaFoldDB; Q2G0R9; -.
DR SMR; Q2G0R9; -.
DR STRING; 1280.SAXN108_0554; -.
DR EnsemblBacteria; ABD29630; ABD29630; SAOUHSC_00475.
DR GeneID; 3920335; -.
DR KEGG; sao:SAOUHSC_00475; -.
DR PATRIC; fig|93061.5.peg.429; -.
DR eggNOG; COG0193; Bacteria.
DR HOGENOM; CLU_062456_4_1_9; -.
DR OMA; HVLSKFH; -.
DR BRENDA; 3.1.1.29; 3352.
DR PRO; PR:Q2G0R9; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00462; PTH; 1.
DR Gene3D; 3.40.50.1470; -; 1.
DR HAMAP; MF_00083; Pept_tRNA_hydro_bact; 1.
DR InterPro; IPR001328; Pept_tRNA_hydro.
DR InterPro; IPR018171; Pept_tRNA_hydro_CS.
DR InterPro; IPR036416; Pept_tRNA_hydro_sf.
DR PANTHER; PTHR17224; PTHR17224; 1.
DR Pfam; PF01195; Pept_tRNA_hydro; 1.
DR SUPFAM; SSF53178; SSF53178; 1.
DR TIGRFAMs; TIGR00447; pth; 1.
DR PROSITE; PS01195; PEPT_TRNA_HYDROL_1; 1.
DR PROSITE; PS01196; PEPT_TRNA_HYDROL_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..190
FT /note="Peptidyl-tRNA hydrolase"
FT /id="PRO_0000264113"
FT STRAND 2..6
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 12..14
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 18..20
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 21..32
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 44..53
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 55..63
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 65..68
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 69..78
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 86..92
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 99..105
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 112..121
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 126..132
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 137..139
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 142..146
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 152..175
FT /evidence="ECO:0007829|PDB:4YLY"
FT HELIX 178..185
FT /evidence="ECO:0007829|PDB:4YLY"
FT STRAND 186..188
FT /evidence="ECO:0007829|PDB:4YLY"
SQ SEQUENCE 190 AA; 21703 MW; 1F5E8C2502C466D8 CRC64;
MKCIVGLGNI GKRFELTRHN IGFEVVDYIL EKNNFSLDKQ KFKGAYTIER MNGDKVLFIE
PMTMMNLSGE AVAPIMDYYN VNPEDLIVLY DDLDLEQGQV RLRQKGSAGG HNGMKSIIKM
LGTDQFKRIR IGVGRPTNGM TVPDYVLQRF SNDEMVTMEK VIEHAARAIE KFVETSRFDH
VMNEFNGEVK