PTKC_ECO57
ID PTKC_ECO57 Reviewed; 451 AA.
AC P69832; P37189; P76411;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=PTS system galactitol-specific EIIC component {ECO:0000250|UniProtKB:P69831};
DE AltName: Full=EIIC-Gat {ECO:0000250|UniProtKB:P69831};
DE AltName: Full=Galactitol permease IIC component {ECO:0000250|UniProtKB:P69831};
GN Name=gatC; OrderedLocusNames=Z3255, ECs2895;
OS Escherichia coli O157:H7.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83334;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX PubMed=11206551; DOI=10.1038/35054089;
RA Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA Blattner F.R.;
RT "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL Nature 409:529-533(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA Shiba T., Hattori M., Shinagawa H.;
RT "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT genomic comparison with a laboratory strain K-12.";
RL DNA Res. 8:11-22(2001).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (PTS), a major carbohydrate active transport system, catalyzes
CC the phosphorylation of incoming sugar substrates concomitant with their
CC translocation across the cell membrane. The enzyme II complex composed
CC of GatA, GatB and GatC is involved in galactitol transport.
CC {ECO:0000250|UniProtKB:P69831}.
CC -!- SUBUNIT: Forms a complex with one each of subunit of GatA, GatB and 2
CC subunits of GatC. {ECO:0000250|UniProtKB:P69831}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|PROSITE-
CC ProRule:PRU00427}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC ProRule:PRU00427}.
CC -!- INDUCTION: Constitutively expressed. {ECO:0000250|UniProtKB:P69831}.
CC -!- DOMAIN: The EIIC domain forms the PTS system translocation channel and
CC contains the specific substrate-binding site. {ECO:0000255|PROSITE-
CC ProRule:PRU00427}.
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DR EMBL; AE005174; AAG57149.1; -; Genomic_DNA.
DR EMBL; BA000007; BAB36318.1; -; Genomic_DNA.
DR PIR; A85836; A85836.
DR PIR; G90990; G90990.
DR RefSeq; NP_310922.1; NC_002695.1.
DR RefSeq; WP_000490679.1; NZ_SWKA01000005.1.
DR AlphaFoldDB; P69832; -.
DR STRING; 155864.EDL933_3161; -.
DR EnsemblBacteria; AAG57149; AAG57149; Z3255.
DR EnsemblBacteria; BAB36318; BAB36318; ECs_2895.
DR GeneID; 916597; -.
DR KEGG; ece:Z3255; -.
DR KEGG; ecs:ECs_2895; -.
DR PATRIC; fig|386585.9.peg.3027; -.
DR eggNOG; COG3775; Bacteria.
DR HOGENOM; CLU_040393_0_0_6; -.
DR OMA; VFDMGWP; -.
DR Proteomes; UP000000558; Chromosome.
DR Proteomes; UP000002519; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015577; F:galactitol transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0019402; P:galactitol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR InterPro; IPR013853; GatC.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR004703; PTS_sugar-sp_permease.
DR PANTHER; PTHR37324; PTHR37324; 1.
DR Pfam; PF03611; EIIC-GAT; 1.
DR PIRSF; PIRSF006304; GatC; 1.
DR TIGRFAMs; TIGR00827; EIIC-GAT; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Galactitol metabolism; Membrane;
KW Phosphotransferase system; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..451
FT /note="PTS system galactitol-specific EIIC component"
FT /id="PRO_0000186571"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 392..412
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
FT DOMAIN 6..435
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00427"
SQ SEQUENCE 451 AA; 48365 MW; B843BB6BDE721F13 CRC64;
MFSEVMRYIL DLGPTVMLPI VIIIFSKILG MKAGDCFKAG LHIGIGFVGI GLVIGLMLDS
IGPAAKAMAE NFDLNLHVVD VGWPGSSPMT WASQIALVAI PIAILVNVAM LLTRMTRVVN
VDIWNIWHMT FTGALLHLAT GSWMIGMAGV VIHAAFVYKL GDWFARDTRN FFELEGIAIP
HGTSAYMGPI AVLVDAIIEK IPGVNRIKFS ADDIQRKFGP FGEPVTVGFV MGLIIGILAG
YDVKGVLQLA VKTAAVMLLM PRVIKPIMDG LTPIAKQARS RLQAKFGGQE FLIGLDPALL
LGHTAVVSAS LIFIPLTILI AVCVPGNQVL PFGDLATIGF FVAMAVAVHR GNLFRTLISG
VIIMSITLWI ATQTIGLHTQ LAANAGALKA GGMVASMDQG GSPITWLLIQ VFSPQNIPGF
IIIGAIYLTG IFMTWRRARG FIKQEKVVLA E
