ID   PTLC_BORPA              Reviewed;         824 AA.
AC   Q7W2U3;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Type IV secretion system protein PtlC homolog;
GN   Name=ptlC; OrderedLocusNames=BPP4311;
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   TRANSCRIPTIONAL SILENCING.
RC   STRAIN=ATCC 9305;
RX   PubMed=3584073; DOI=10.1128/jb.169.6.2847-2853.1987;
RA   Arico B., Rappuoli R.;
RT   "Bordetella parapertussis and Bordetella bronchiseptica contain
RT   transcriptionally silent pertussis toxin genes.";
RL   J. Bacteriol. 169:2847-2853(1987).
RN   [3]
RP   POSSIBLE EXPRESSION OF PTL AND PTX PROTEINS UNDER CONDITIONS DIFFERENT FROM
RP   B.PERTUSSIS EXPRESSION CONDITIONS.
RC   STRAIN=10978, and 13449;
RX   PubMed=8926063; DOI=10.1128/iai.64.10.4020-4026.1996;
RA   Hausman S.Z., Cherry J.D., Heininger U., Wirsing von Koenig C.H.,
RA   Burns D.L.;
RT   "Analysis of proteins encoded by the ptx and ptl genes of Bordetella
RT   bronchiseptica and Bordetella parapertussis.";
RL   Infect. Immun. 64:4020-4026(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TrbE/VirB4 family. {ECO:0000305}.
CC   -!- CAUTION: B.parapertussis and B.bronchiseptica seem not to produce the
CC       pertussis toxin (S1, S2, S4, S5 and S3) and ptl proteins (PtlA, PtlB,
CC       PtlC, PtlD, PtlE, PtlF, PtlG, PtlH and PtlI) in vivo due to changes in
CC       the promoter region of the ptx-ptl operon. However, it is possible that
CC       their promoter is active under certain, as-yet-undefined conditions and
CC       that B.parapertussis and B.bronchiseptica are therefore capable of
CC       producing these proteins. {ECO:0000305}.
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DR   EMBL; BX640436; CAE39589.1; -; Genomic_DNA.
DR   RefSeq; WP_010929495.1; NC_002928.3.
DR   AlphaFoldDB; Q7W2U3; -.
DR   SMR; Q7W2U3; -.
DR   EnsemblBacteria; CAE39589; CAE39589; BPP4311.
DR   KEGG; bpa:BPP4311; -.
DR   HOGENOM; CLU_008341_3_0_4; -.
DR   OMA; MFMDEFW; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR004346; CagE_TrbE_VirB.
DR   InterPro; IPR018145; CagE_TrbE_VirB_cntrl_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF03135; CagE_TrbE_VirB; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00929; VirB4_CagE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding.
FT   CHAIN           1..824
FT                   /note="Type IV secretion system protein PtlC homolog"
FT                   /id="PRO_0000287410"
FT   BINDING         456..463
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   824 AA;  92664 MW;  C3C9E8D46FF8AE44 CRC64;
     MNRRGGQTAF AAIARNERAI AAFIPYSSHL TDTTLITHGA DLVRTWRVQG IAFESAEPEL
     VSQRHEQLNG LWRAISCEQV ALWIHCIRRK TQAGLDARYE NPFCRALDAS YNARLNARQA
     MTNEFYLTLV YRPGHAALGK RAHHGQAEVR RQLLAHVRRM DEIGSLIETT LRSHGENHEQ
     AITVLGCETD SAGRRYSRTL TLLEFLLTGH WQPVRVPAGP VDAYLGSSRI LAGAEMMELR
     SPTCRRYAQF IDFKEYGTHT EPGMLNALLY EDYEYVITHS FSAVGKRQAL AYLQRQRAQL
     ANVQDAAYSQ IDDLAHAEDA LVNGDFVIGE YHFSMMILGA DPRQLRRDVS SAMTRIQERG
     FLATPVTLAL DAAFYAQLPA NWAYRPRKAM LTSRNFAGLC SFHNFYGGKR DGNPWGPALS
     LLSTPSGQPF YFNFHHSGLD EDCRGQMMLG NTRIIGQSGS GKTVLLNFLL CQLQKFRSAD
     ADGLTTIFFD KDRGAEICIR ALDGQYLRIR DGEPTGFNPL QLPCTDRNVM FLDSLLAMLA
     RAHDSPLTSA QHATLATAVR TVLRMPASLR RMSTLLQNIT QATSEQRELV RRLGRWCRDD
     GAGGTGMLWW VFDNPNDCLD FSRPGNYGID GTAFLDNAET RTPISMYLLH RMNEAMDGRR
     FVYLMDEAWK WIDDPAFAEF AGDQQLTIRK KNGLGVFSTQ MPSSLLGARV AASLVQQCAT
     EIYLPNPRAD RAEYLDGFKC TETEYQLIRS MAEDSHLFLV KQGRQAVVAQ LDLSGMDDEL
     AILSGNARNL RCFEQALALT RERDPNDWIA VFHRLRREAS AGLR