ID   PTLD_BORBR              Reviewed;         461 AA.
AC   Q7WDU0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Type IV secretion system protein PtlD homolog;
DE   Flags: Precursor;
GN   Name=ptlD; OrderedLocusNames=BB4898;
OS   Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS   (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   TRANSCRIPTIONAL SILENCING.
RC   STRAIN=ATCC 4617 / NCIB 9935 / NCTC 8344 / NRRL B-140;
RX   PubMed=3584073; DOI=10.1128/jb.169.6.2847-2853.1987;
RA   Arico B., Rappuoli R.;
RT   "Bordetella parapertussis and Bordetella bronchiseptica contain
RT   transcriptionally silent pertussis toxin genes.";
RL   J. Bacteriol. 169:2847-2853(1987).
RN   [3]
RP   POSSIBLE EXPRESSION OF PTL AND PTX PROTEINS UNDER CONDITIONS DIFFERENT FROM
RP   B.PERTUSSIS EXPRESSION CONDITIONS.
RC   STRAIN=ATCC 31437 / Bb55;
RX   PubMed=8926063; DOI=10.1128/iai.64.10.4020-4026.1996;
RA   Hausman S.Z., Cherry J.D., Heininger U., Wirsing von Koenig C.H.,
RA   Burns D.L.;
RT   "Analysis of proteins encoded by the ptx and ptl genes of Bordetella
RT   bronchiseptica and Bordetella parapertussis.";
RL   Infect. Immun. 64:4020-4026(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- CAUTION: B.parapertussis and B.bronchiseptica seem not to produce the
CC       pertussis toxin (S1, S2, S4, S5 and S3) and ptl proteins (PtlA, PtlB,
CC       PtlC, PtlD, PtlE, PtlF, PtlG, PtlH and PtlI) in vivo due to changes in
CC       the promoter region of the ptx-ptl operon. However, it is possible that
CC       their promoter is active under certain, as-yet-undefined conditions and
CC       that B.parapertussis and B.bronchiseptica are therefore capable of
CC       producing these proteins. {ECO:0000305}.
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DR   EMBL; BX640451; CAE35261.1; -; Genomic_DNA.
DR   RefSeq; WP_003815860.1; NC_002927.3.
DR   AlphaFoldDB; Q7WDU0; -.
DR   STRING; 257310.BB4898; -.
DR   EnsemblBacteria; CAE35261; CAE35261; BB4898.
DR   KEGG; bbr:BB4898; -.
DR   HOGENOM; CLU_592732_0_0_4; -.
DR   OMA; LMMAMYE; -.
DR   OrthoDB; 171237at28216; -.
DR   Proteomes; UP000001027; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030255; P:protein secretion by the type IV secretion system; IEA:InterPro.
DR   InterPro; IPR007688; Conjugal_tfr_TrbL/VirB6.
DR   Pfam; PF04610; TrbL; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..461
FT                   /note="Type IV secretion system protein PtlD homolog"
FT                   /id="PRO_0000287403"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          376..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        435..451
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  48510 MW;  4A97309177F01CF7 CRC64;
     MAGLSRILLS CTLACLLAGQ AAQASVDDPT RAGGDNRVRA LRADQARRDV LLTACRDDPG
     HRRGEPDCVN AERAQALQQW QAAAMTSVDA AFSDLAGALR NAAPRRMEAA IVRLTRQLQP
     LVYSMMTLLV LLTGYALLAR RDRPFEWHIR HALLVAVVTS LALSPDRYLS TVVAGVQDVA
     GWLSGPWTAP DGAAGRGGLA QLDQFAAQAQ AWVAQLAGQA ANDANPGSAV NWLLCAMIVA
     ASAGGWLCLA ASLLIVPGLI VTLLLSLGPL FLVLLLFPAL QRWTNAWLGA LVRALVFMAL
     GTPAVGLLSD VLAGALPAGL PQRFATDPLR STMLAATLCA TATLMLLTLV PLASSVNAGL
     RRRLWPNAAH PGLAQAHRQA AARQYAPRPA AAAAAAGPHQ AGTYAASATP APARPAPSFP
     AHAYRQYALG GARRPPPRVR RDDRPAPAPD RRVLPRKPNL P