ID   PTLG_BORPA              Reviewed;         374 AA.
AC   Q7W2T8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Type IV secretion system protein PtlG homolog;
GN   Name=ptlG; OrderedLocusNames=BPP4315;
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   TRANSCRIPTIONAL SILENCING.
RC   STRAIN=ATCC 9305;
RX   PubMed=3584073; DOI=10.1128/jb.169.6.2847-2853.1987;
RA   Arico B., Rappuoli R.;
RT   "Bordetella parapertussis and Bordetella bronchiseptica contain
RT   transcriptionally silent pertussis toxin genes.";
RL   J. Bacteriol. 169:2847-2853(1987).
RN   [3]
RP   POSSIBLE EXPRESSION OF PTL AND PTX PROTEINS UNDER CONDITIONS DIFFERENT FROM
RP   B.PERTUSSIS EXPRESSION CONDITIONS.
RC   STRAIN=10978, and 13449;
RX   PubMed=8926063; DOI=10.1128/iai.64.10.4020-4026.1996;
RA   Hausman S.Z., Cherry J.D., Heininger U., Wirsing von Koenig C.H.,
RA   Burns D.L.;
RT   "Analysis of proteins encoded by the ptx and ptl genes of Bordetella
RT   bronchiseptica and Bordetella parapertussis.";
RL   Infect. Immun. 64:4020-4026(1996).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TrbI/VirB10 family. {ECO:0000305}.
CC   -!- CAUTION: B.parapertussis and B.bronchiseptica seem not to produce the
CC       pertussis toxin (S1, S2, S4, S5 and S3) and Ptl proteins (PtlA, PtlB,
CC       PtlC, PtlD, PtlE, PtlF, PtlG, PtlH and PtlI) in vivo due to changes in
CC       the promoter region of the ptx-ptl operon. However, it is possible that
CC       their promoter is active under certain, as-yet-undefined conditions and
CC       that B.parapertussis and B.bronchiseptica are therefore capable of
CC       producing these proteins. {ECO:0000305}.
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DR   EMBL; BX640436; CAE39594.1; -; Genomic_DNA.
DR   RefSeq; WP_010929499.1; NC_002928.3.
DR   AlphaFoldDB; Q7W2T8; -.
DR   SMR; Q7W2T8; -.
DR   EnsemblBacteria; CAE39594; CAE39594; BPP4315.
DR   KEGG; bpa:BPP4315; -.
DR   HOGENOM; CLU_041899_7_0_4; -.
DR   OMA; PGKDRNT; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd16429; VirB10; 1.
DR   Gene3D; 2.40.128.260; -; 1.
DR   InterPro; IPR005498; T4SS_VirB10/TraB/TrbI.
DR   InterPro; IPR042217; T4SS_VirB10/TrbI.
DR   Pfam; PF03743; TrbI; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..374
FT                   /note="Type IV secretion system protein PtlG homolog"
FT                   /id="PRO_0000287416"
FT   TRANSMEM        38..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          87..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..116
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   374 AA;  39475 MW;  6B044374963779FC CRC64;
     MLNRPSSPDG GEAHAWPPDP EIPVFANAEH AHRRPLRWMF ALVAVALSCL LATGIWRSRA
     APPHAATQTV APAGQALPPG RMFTVHPREP EPAPLPDMPA APNPILPQPR PAPPVPPPPI
     RAPYDYDEPA PRRDSAALKS GPAMMVATAA RLGQTERAGM AEDGVSADAA TLIGRSVSRA
     TRSGGRDYRL LPGTFIDCIL QTRIVTNVPG LTTCIVSRDV YSASGKRVLV PRGTTVVGEY
     RADLAQGSQR IYVAWSRLFM PSGLTIELAS PAVDGTGAAG LPGVVDDKFA QRFGGALLLS
     VLGDATSYML ARATDARHGV NVNLTAAGTM NSLAASALNN TINIPPTLYK NHGDQIGILV
     ARPLDFSILR GTNE