ID   PTLH_BORBR              Reviewed;         339 AA.
AC   Q7WDT5;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Type IV secretion system protein PtlH homolog;
GN   Name=ptlH; OrderedLocusNames=BB4902;
OS   Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS   (Alcaligenes bronchisepticus).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [2]
RP   TRANSCRIPTIONAL SILENCING.
RC   STRAIN=ATCC 4617 / NCIB 9935 / NCTC 8344 / NRRL B-140;
RX   PubMed=3584073; DOI=10.1128/jb.169.6.2847-2853.1987;
RA   Arico B., Rappuoli R.;
RT   "Bordetella parapertussis and Bordetella bronchiseptica contain
RT   transcriptionally silent pertussis toxin genes.";
RL   J. Bacteriol. 169:2847-2853(1987).
RN   [3]
RP   POSSIBLE EXPRESSION OF PTL AND PTX PROTEINS UNDER CONDITIONS DIFFERENT FROM
RP   B.PERTUSSIS EXPRESSION CONDITIONS.
RC   STRAIN=ATCC 31437 / Bb55;
RX   PubMed=8926063; DOI=10.1128/iai.64.10.4020-4026.1996;
RA   Hausman S.Z., Cherry J.D., Heininger U., Wirsing von Koenig C.H.,
RA   Burns D.L.;
RT   "Analysis of proteins encoded by the ptx and ptl genes of Bordetella
RT   bronchiseptica and Bordetella parapertussis.";
RL   Infect. Immun. 64:4020-4026(1996).
CC   -!- SIMILARITY: Belongs to the GSP E family. {ECO:0000305}.
CC   -!- CAUTION: B.parapertussis and B.bronchiseptica seem not to produce the
CC       pertussis toxin (S1, S2, S4, S5 and S3) and Ptl proteins (PtlA, PtlB,
CC       PtlC, PtlD, PtlE, PtlF, PtlG, PtlH and PtlI) in vivo due to changes in
CC       the promoter region of the ptx-ptl operon. However, it is possible that
CC       their promoter is active under certain, as-yet-undefined conditions and
CC       that B.parapertussis and B.bronchiseptica are therefore capable of
CC       producing these proteins. {ECO:0000305}.
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DR   EMBL; BX640451; CAE35266.1; -; Genomic_DNA.
DR   RefSeq; WP_003815867.1; NC_002927.3.
DR   AlphaFoldDB; Q7WDT5; -.
DR   SMR; Q7WDT5; -.
DR   STRING; 257310.BB4902; -.
DR   EnsemblBacteria; CAE35266; CAE35266; BB4902.
DR   KEGG; bbr:BB4902; -.
DR   eggNOG; COG0630; Bacteria.
DR   HOGENOM; CLU_005379_3_1_4; -.
DR   OMA; EAWVEKK; -.
DR   OrthoDB; 473670at2; -.
DR   Proteomes; UP000001027; Chromosome.
DR   GO; GO:0043684; C:type IV secretion system complex; IEA:InterPro.
DR   GO; GO:0044097; P:secretion by the type IV secretion system; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR001482; T2SS/T4SS.
DR   InterPro; IPR014155; VirB11.
DR   Pfam; PF00437; T2SSE; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02788; VirB11; 1.
PE   3: Inferred from homology;
FT   CHAIN           1..339
FT                   /note="Type IV secretion system protein PtlH homolog"
FT                   /id="PRO_0000287417"
SQ   SEQUENCE   339 AA;  37129 MW;  7A7E6D9C6085D4C5 CRC64;
     MNDAAPDRQA SVDFHLQALH PWLSRQDIAE ICVNRPGQLW YEDRNGWNRQ ESGALTLDHL
     HALATATARF CDRDICPERP LLAASLPGGE RVQIVVPPAC EPGTLSLTIR KPARRIWPLS
     ELLRDALDLP GVPGASQARP DPLLDPWRRG AWDDFLRLAV QAGKAILVAG QTGSGKTTLM
     NALSGEIPPR ERIVTIEDVR ELRLDPATNH VHLLYGTPTE GRTAAVSATE LLRAALRMAP
     TRILLAELRG GEAFDFLQAC ASGHSGGIST CHAASADMAL QRLTLMCMQH PNCQMLPYST
     LRALVESVID IVVVVERRAG QGARRRVVDI WYRDGLPAP