ID   PTLI_BORPE              Reviewed;          61 AA.
AC   Q7VSX7;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Type IV secretion system protein PtlI;
DE   AltName: Full=Pertussis toxin liberation protein I;
DE   Flags: Precursor;
GN   Name=ptlI; OrderedLocusNames=BP3792;
OS   Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=Tohama I / BP338;
RX   PubMed=8464913; DOI=10.1073/pnas.90.7.2970;
RA   Weiss A.A., Johnson F.D., Burns D.L.;
RT   "Molecular characterization of an operon required for pertussis toxin
RT   secretion.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:2970-2974(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
RN   [3]
RP   REGULATION BY BVGS/BVGA.
RC   STRAIN=Tohama I / ATCC BAA-589 / NCTC 13251;
RX   PubMed=7592424; DOI=10.1128/jb.177.22.6486-6491.1995;
RA   Boucher P.E., Stibitz S.;
RT   "Synergistic binding of RNA polymerase and BvgA phosphate to the pertussis
RT   toxin promoter of Bordetella pertussis.";
RL   J. Bacteriol. 177:6486-6491(1995).
RN   [4]
RP   COTRANSCRIPTION WITH PTX.
RC   STRAIN=Wellcome 28;
RX   PubMed=8606119; DOI=10.1128/iai.64.4.1458-1460.1996;
RA   Ricci S., Rappuoli R., Scarlato V.;
RT   "The pertussis toxin liberation genes of Bordetella pertussis are
RT   transcriptionally linked to the pertussis toxin operon.";
RL   Infect. Immun. 64:1458-1460(1996).
RN   [5]
RP   IDENTIFICATION OF PTLI, AND INTERACTION WITH PTLF.
RC   STRAIN=Tohama I / BP338;
RX   PubMed=8940184; DOI=10.1074/jbc.271.49.31643;
RA   Farizo K.M., Cafarella T.G., Burns D.L.;
RT   "Evidence for a ninth gene, ptlI, in the locus encoding the pertussis toxin
RT   secretion system of Bordetella pertussis and formation of a PtlI-PtlF
RT   complex.";
RL   J. Biol. Chem. 271:31643-31649(1996).
RN   [6]
RP   FUNCTION.
RC   STRAIN=Tohama I / BP338;
RX   PubMed=10518754; DOI=10.1111/j.1574-6968.1999.tb08766.x;
RA   Craig-Mylius K.A., Weiss A.A.;
RT   "Mutants in the ptlA-H genes of Bordetella pertussis are deficient for
RT   pertussis toxin secretion.";
RL   FEMS Microbiol. Lett. 179:479-484(1999).
RN   [7]
RP   FUNCTION.
RC   STRAIN=Tohama I / BP338;
RX   PubMed=15322034; DOI=10.1128/iai.72.9.5365-5372.2004;
RA   Burns D.L., Fiddner S., Cheung A.M., Verma A.;
RT   "Analysis of subassemblies of pertussis toxin subunits in vivo and their
RT   interaction with the ptl transport apparatus.";
RL   Infect. Immun. 72:5365-5372(2004).
CC   -!- FUNCTION: Component of the type IV secretion system ptl required for
CC       secretion of assembled pertussis toxin (PTX) through the outer
CC       membrane. {ECO:0000269|PubMed:10518754, ECO:0000269|PubMed:15322034,
CC       ECO:0000269|PubMed:8464913}.
CC   -!- SUBUNIT: Forms a complex with PtlF.
CC   -!- INDUCTION: Cotranscribed with ptxABCDE. Activated by the two-component
CC       regulatory system BvgS/BvgA.
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DR   EMBL; L10720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX640422; CAE44047.1; -; Genomic_DNA.
DR   RefSeq; NP_882291.1; NC_002929.2.
DR   RefSeq; WP_010929497.1; NZ_CP039022.1.
DR   AlphaFoldDB; Q7VSX7; -.
DR   STRING; 257313.BP3792; -.
DR   GeneID; 66440817; -.
DR   KEGG; bpe:BP3792; -.
DR   PATRIC; fig|257313.5.peg.4096; -.
DR   HOGENOM; CLU_2913301_0_0_4; -.
DR   Proteomes; UP000002676; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal; Transport.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..61
FT                   /note="Type IV secretion system protein PtlI"
FT                   /id="PRO_0000262580"
FT   REGION          37..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   61 AA;  6294 MW;  291A95E93F406D86 CRC64;
     MIHAHSNARL LRWAILAIAP VTLGACAPNG PPGLPYPDGK PLIPINTAAP EQGSSCQTRA
     P