ID   PTMAA_DANRE             Reviewed;         105 AA.
AC   Q6NV32; Q8QGP0;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Prothymosin alpha-A;
GN   Name=ptmaa; Synonyms=ptma; ORFNames=zgc:85633;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Marty S.D., Huang H., Lin S.;
RT   "A zebrafish prothymosin alpha-like protein selectively enhances
RT   proliferation of embryonic hematopoietic progenitor cells.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION AS PTMAA, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=18351673; DOI=10.1002/dvdy.21492;
RA   Donizetti A., Liccardo D., Esposito D., Del Gaudio R., Locascio A.,
RA   Ferrara D., Minucci S., Aniello F.;
RT   "Differential expression of duplicated genes for prothymosin alpha during
RT   zebrafish development.";
RL   Dev. Dyn. 237:1112-1118(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: At the 20-somite stage (18 hpf), expressed on the
CC       dorsal side of the embryo in the developing central and peripheral
CC       nervous system (CNS and PNS), in the tail bud and the pronephric ducts.
CC       In the PNS, expressed in the otic vesicle, trigeminal ganglion and the
CC       anterior lateral line placode. Localized throughout the hindbrain, with
CC       highest expression in rhombomeres 3 and 4. In the head, expressed in
CC       the olfactory placode and in the diencephalic region. At the end of the
CC       segmentation period (20 hpf), expression begins in the newly forming
CC       endodermal pouches, and weakly in the pharyngeal arch precursor cells.
CC       During the early pharyngula period, expressed in the pectoral fin bud,
CC       the developing retina, and still present in the central nervous system
CC       and endodermal pouches. In the tail, expressed in the spinal cord and
CC       posterior lateral line precursors. Weakly expressed in the pronephric
CC       ducts, only in the corpuscles of Stanius. At 48 hpf, still expressed in
CC       the retina and brain, where expression is almost uniform. At this
CC       stage, expression is decreased in the spinal cord and is absent from
CC       the lateral line cells and pronephric ducts, but appears in the
CC       intestine and continues in the pharyngeal arches. In 72 hpf embryos,
CC       expression in the brain remains uniform but is restricted to amacrine
CC       cells in the retina. In the pharyngeal arches, expression continues to
CC       be limited to the ectodermal and endodermal covering cells.
CC       {ECO:0000269|PubMed:18351673}.
CC   -!- DEVELOPMENTAL STAGE: Expression begins at 16 hpf and gradually
CC       increases up to 72 hpf. {ECO:0000269|PubMed:18351673}.
CC   -!- SIMILARITY: Belongs to the pro/parathymosin family. {ECO:0000305}.
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DR   EMBL; BC068334; AAH68334.1; -; mRNA.
DR   EMBL; AF372502; AAM18634.1; -; mRNA.
DR   RefSeq; NP_919357.2; NM_194376.2.
DR   AlphaFoldDB; Q6NV32; -.
DR   STRING; 7955.ENSDARP00000009093; -.
DR   PaxDb; Q6NV32; -.
DR   GeneID; 335707; -.
DR   KEGG; dre:335707; -.
DR   CTD; 335707; -.
DR   ZFIN; ZDB-GENE-030131-7647; ptmaa.
DR   eggNOG; ENOG502S55T; Eukaryota.
DR   InParanoid; Q6NV32; -.
DR   PRO; PR:Q6NV32; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004931; Pro/parathymosin.
DR   PANTHER; PTHR22745; PTHR22745; 1.
DR   Pfam; PF03247; Prothymosin; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..105
FT                   /note="Prothymosin alpha-A"
FT                   /id="PRO_0000191628"
FT   REGION          1..105
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..77
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        9..11
FT                   /note="SKE -> NKD (in Ref. 1; AAM18634)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   105 AA;  11493 MW;  0C37B96221579C25 CRC64;
     MADTKVDTSK EVSAKDLKEK KQVEEAENGK DAPANGNAEN EENGDQENEV DEEDDDVAEE
     DEEDDGEGDD DDEDEEAEGG TGKRAAEDDD DDEDDVDPKK QKTDV