ID   PTMAB_DANRE             Reviewed;         106 AA.
AC   A5PLC8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Prothymosin alpha-B {ECO:0000303|PubMed:18351673};
GN   Name=ptmab {ECO:0000303|PubMed:18351673}; ORFNames=zgc:165530;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAI42848.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Larval eye {ECO:0000312|EMBL:AAI42848.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   IDENTIFICATION AS PTMAB, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=18351673; DOI=10.1002/dvdy.21492;
RA   Donizetti A., Liccardo D., Esposito D., Del Gaudio R., Locascio A.,
RA   Ferrara D., Minucci S., Aniello F.;
RT   "Differential expression of duplicated genes for prothymosin alpha during
RT   zebrafish development.";
RL   Dev. Dyn. 237:1112-1118(2008).
RN   [3] {ECO:0000305}
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-8 AND THR-10, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Embryo {ECO:0000269|PubMed:18307296};
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P06454}.
CC   -!- TISSUE SPECIFICITY: Uniformly expressed in all embryonic cells at 4 and
CC       8 hpf. At the 20-somite stage (18 hpf), ubiquitously expressed in the
CC       developing nervous system, in the tail bud and in the pronephric ducts.
CC       Also expressed in some placodes, including the anterior lateral line
CC       placode, otic vesicle and olfactory placode. At 27 hpf, strong
CC       expression persists in the central nervous system and the olfactory
CC       placode. Expressed strongly in the eyes and the pectoral fin buds. In
CC       the tail region, expressed in the spinal cord, in the posterior lateral
CC       line precursors, and persists in the pronephric ducts. At 48 hpf,
CC       expressed in all head territories including the developing brain, eyes,
CC       and pharyngeal arches. More caudally, expression persists in the
CC       pectoral fin buds, the spinal cord and, for the first time, appears in
CC       the intestine. At 72 hpf, expressed only in restricted regions of the
CC       brain, in pharyngeal arches region and in the amacrine cells and the
CC       horizontal cells of the retina. {ECO:0000269|PubMed:18351673}.
CC   -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. First
CC       expressed at 4 hpf. Expression is lower by 8 hpf and increases almost
CC       constantly thereafter. {ECO:0000269|PubMed:18351673}.
CC   -!- SIMILARITY: Belongs to the pro/parathymosin family. {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC142847; AAI42848.1; -; mRNA.
DR   RefSeq; NP_001092200.1; NM_001098730.1.
DR   AlphaFoldDB; A5PLC8; -.
DR   SMR; A5PLC8; -.
DR   STRING; 7955.ENSDARP00000103236; -.
DR   iPTMnet; A5PLC8; -.
DR   PaxDb; A5PLC8; -.
DR   PeptideAtlas; A5PLC8; -.
DR   PRIDE; A5PLC8; -.
DR   Ensembl; ENSDART00000164039; ENSDARP00000137701; ENSDARG00000101766.
DR   GeneID; 559194; -.
DR   KEGG; dre:559194; -.
DR   CTD; 559194; -.
DR   ZFIN; ZDB-GENE-030131-8681; ptmab.
DR   eggNOG; ENOG502S5G1; Eukaryota.
DR   GeneTree; ENSGT00950000183307; -.
DR   HOGENOM; CLU_136539_0_1_1; -.
DR   InParanoid; A5PLC8; -.
DR   OMA; DEDDEXX; -.
DR   PRO; PR:A5PLC8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000101766; Expressed in camera-type eye and 45 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IMP:ZFIN.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR004931; Pro/parathymosin.
DR   PANTHER; PTHR22745; PTHR22745; 1.
DR   Pfam; PF03247; Prothymosin; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..106
FT                   /note="Prothymosin alpha-B"
FT                   /id="PRO_0000365453"
FT   REGION          1..106
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..75
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         8
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   MOD_RES         10
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
SQ   SEQUENCE   106 AA;  11781 MW;  16F3034C33D3AECF CRC64;
     MADAKVDSAT EISAKDLKEK KLIEEKENGK DATNGKENEE NGEPEIDDED DDEVDEDDEE
     GEGDEDEDED DDDEDLGGGT KRGADDDEDE DEDDEDDVDP KKQKVN