ATP5J_MACFA
ID ATP5J_MACFA Reviewed; 108 AA.
AC Q8SPH6;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=ATP synthase-coupling factor 6, mitochondrial {ECO:0000305};
DE Short=ATPase subunit F6;
DE AltName: Full=ATP synthase peripheral stalk subunit F6 {ECO:0000305};
DE Flags: Precursor;
GN Name=ATP5PF {ECO:0000250|UniProtKB:P18859}; Synonyms=ATP5J;
GN ORFNames=QnpA-21593;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Parietal cortex;
RX PubMed=11991714; DOI=10.1006/geno.2002.6753;
RA Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S., Hirai M.,
RA Hashimoto K.;
RT "Search for genes positively selected during primate evolution by 5'-end-
RT sequence screening of cynomolgus monkey cDNAs.";
RL Genomics 79:657-662(2002).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Part of the complex
CC F(0) domain and the peripheric stalk, which acts as a stator to hold
CC the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static
CC relative to the rotary elements. Also involved in the restoration of
CC oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
CC -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC - and CF(0) - the membrane proton channel. CF(0) seems to have nine
CC subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP
CC synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME,
CC ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C,
CC ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion inner membrane.
CC -!- SIMILARITY: Belongs to the eukaryotic ATPase subunit F6 family.
CC {ECO:0000305}.
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DR EMBL; AB072025; BAB86814.1; -; mRNA.
DR RefSeq; NP_001271827.1; NM_001284898.1.
DR RefSeq; XP_015302102.1; XM_015446616.1.
DR RefSeq; XP_015302103.1; XM_015446617.1.
DR AlphaFoldDB; Q8SPH6; -.
DR SMR; Q8SPH6; -.
DR STRING; 9541.XP_005548947.1; -.
DR Ensembl; ENSMFAT00000000698; ENSMFAP00000026517; ENSMFAG00000044695.
DR GeneID; 102117567; -.
DR KEGG; mcf:102117567; -.
DR CTD; 522; -.
DR VEuPathDB; HostDB:ENSMFAG00000044695; -.
DR eggNOG; KOG4634; Eukaryota.
DR GeneTree; ENSGT00390000008902; -.
DR OMA; PKFEVFD; -.
DR Proteomes; UP000233100; Chromosome 3.
DR Bgee; ENSMFAG00000044695; Expressed in heart and 13 other tissues.
DR GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
DR GO; GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IEA:InterPro.
DR GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015986; P:proton motive force-driven ATP synthesis; IEA:InterPro.
DR Gene3D; 1.10.246.110; -; 1.
DR InterPro; IPR008387; ATP_synth_f6_mt.
DR InterPro; IPR036204; ATP_synth_f6_sf_mt.
DR PANTHER; PTHR12441; PTHR12441; 1.
DR Pfam; PF05511; ATP-synt_F6; 1.
DR PIRSF; PIRSF002455; ATP_synthase_coupling_factor_6; 1.
DR SUPFAM; SSF111357; SSF111357; 1.
PE 3: Inferred from homology;
KW Acetylation; CF(0); Hydrogen ion transport; Ion transport; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transport.
FT TRANSIT 1..32
FT /note="Mitochondrion"
FT /evidence="ECO:0000250"
FT CHAIN 33..108
FT /note="ATP synthase-coupling factor 6, mitochondrial"
FT /id="PRO_0000002528"
FT MOD_RES 41
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P18859"
FT MOD_RES 46
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P18859"
FT MOD_RES 79
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P97450"
FT MOD_RES 84
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P97450"
FT MOD_RES 84
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P97450"
FT MOD_RES 94
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P97450"
FT MOD_RES 94
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P97450"
FT MOD_RES 99
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P18859"
FT MOD_RES 99
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P97450"
FT MOD_RES 105
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P18859"
SQ SEQUENCE 108 AA; 12587 MW; A33AC44891716C1E CRC64;
MILQRLFRFS SIIRSAVSVH FRRNIGVTAV AFNKELDPVQ KLFVDKIREY KSKRQTSGGP
VDTGPEYQQE LEKELFKLKQ MFGKADMNTF PTFKFEDPKF EVIEKPPA
