PTMS_BOVIN
ID PTMS_BOVIN Reviewed; 102 AA.
AC P08814;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Parathymosin;
GN Name=PTMS;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP PROTEIN SEQUENCE OF 2-102.
RX PubMed=3421960; DOI=10.1016/s0006-291x(88)80528-x;
RA Panneerselvam C., Clinton M., Wellner D., Horecker B.L.;
RT "Bovine parathymosin: amino acid sequence and comparison with rat
RT parathymosin.";
RL Biochem. Biophys. Res. Commun. 155:539-545(1988).
CC -!- FUNCTION: Parathymosin may mediate immune function by blocking the
CC effect of prothymosin alpha which confers resistance to certain
CC opportunistic infections.
CC -!- SIMILARITY: Belongs to the pro/parathymosin family. {ECO:0000305}.
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DR AlphaFoldDB; P08814; -.
DR SMR; P08814; -.
DR STRING; 9913.ENSBTAP00000024555; -.
DR PaxDb; P08814; -.
DR PeptideAtlas; P08814; -.
DR PRIDE; P08814; -.
DR eggNOG; ENOG502SSXW; Eukaryota.
DR InParanoid; P08814; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004931; Pro/parathymosin.
DR PANTHER; PTHR22745; PTHR22745; 1.
DR Pfam; PF03247; Prothymosin; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Immunity; Phosphoprotein;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P20962,
FT ECO:0000269|PubMed:3421960"
FT CHAIN 2..102
FT /note="Parathymosin"
FT /id="PRO_0000191631"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..81
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P20962"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P20962"
FT MOD_RES 4
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P20962"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P20962"
FT MOD_RES 13
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D0J8"
FT MOD_RES 15
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P20962"
FT MOD_RES 52
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P04550"
FT MOD_RES 92
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P20962"
SQ SEQUENCE 102 AA; 11457 MW; D7438E901F63F99C CRC64;
MSEKSVEAAA ELSAKDLKEK KEKVEEKAGR KERKKEVVEE EENGAEEEEE ETAEDGEEED
DGDEEDEEEE EEEDEGPALV RAAEEEDEAD PKRQKTENGA SA
