ID   PTMT_PENSI              Reviewed;         570 AA.
AC   A0A140JWS3;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   11-MAY-2016, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=MFS-type transporter ptmT {ECO:0000303|PubMed:25831977};
DE   AltName: Full=Penitrem biosynthesis cluster 1 protein T {ECO:0000303|PubMed:25831977};
GN   Name=ptmT {ECO:0000303|PubMed:25831977};
OS   Penicillium simplicissimum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=69488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], IDENTIFICATION, AND FUNCTION.
RC   STRAIN=AK-40;
RX   PubMed=25831977; DOI=10.1002/anie.201501072;
RA   Liu C., Tagami K., Minami A., Matsumoto T., Frisvad J.C., Suzuki H.,
RA   Ishikawa J., Gomi K., Oikawa H.;
RT   "Reconstitution of biosynthetic machinery for the synthesis of the highly
RT   elaborated indole diterpene penitrem.";
RL   Angew. Chem. Int. Ed. 54:5748-5752(2015).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of the indole diterpenes penitrems (PubMed:25831977).
CC       May be involved in the efflux of penitrems (Probable).
CC       {ECO:0000269|PubMed:25831977, ECO:0000305|PubMed:25831977}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; LC027936; BAU61550.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A140JWS3; -.
DR   SMR; A0A140JWS3; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..570
FT                   /note="MFS-type transporter ptmT"
FT                   /id="PRO_0000446591"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        379..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        413..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        445..465
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        517..537
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        541
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   570 AA;  61196 MW;  AFDF06700B66BEBF CRC64;
     MPDSGNIQLD TLQHKDHSQE TTSHYEGGSQ LPEQESLDTN IQDDSVEYPG LIRVILITMG
     VALCSFCVGL DNTILATAIP KITSEFNSLE DMSWYVSAYL LVTSAFILSF GKIYTYYSVK
     WTYLISLGLF ELGSLICAIT PSSAGLIVGR AISGLGSAGL FPGSVIILSN IAPLHQRPLL
     TAFIGIMSGI ATVTGPILGG VFTDRLSWRW CFYINLPIGG VTAVVVFLFM KTMKVKKNVP
     TSQKIKGLDW IGTAVFIPAI VSLLLALQWG GARYNWQNVR IIMLFIIAGV LGMVWLLIQR
     WKKEEATIPP RLMQRRSVVG TCIYTIPFVG CVIVLGYYLP IWFQSVKGVS ASQSGIMNLP
     TVVGTIVVGL LSSVLIMRVG YMMPFLVLGS VMLAVGAGLC STFQRSSGSA EWIGYQAMIG
     MGAGLGYQLP LLVVQADVPA ADVPVATAVV IFMQNLAGSI FSAIAQTVFQ NQLANSVQIL
     APSVNPESIL DGGTVDLSDR FPSDVLPSIL QAYNTAVTHT FYAGVAAASL SVFGAFIVRW
     NVSVKKKVPP EPLVPGGSHS GAERDSKNGT