PTN20_HUMAN
ID PTN20_HUMAN Reviewed; 420 AA.
AC Q4JDL3; A6NNH8; B7ZKV3; Q4JDG6; Q4JDK1; Q4JDK5; Q4JDK6; Q4JDK8; Q4JDK9;
AC Q4JDL0; Q4JDL1; Q4JDL4; Q4JDL5; Q4JDL6; Q4JDL7; Q4JDL8; Q5RJ33; Q5T1G3;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type 20;
DE Short=hPTPN20;
DE EC=3.1.3.48;
GN Name=PTPN20 {ECO:0000312|HGNC:HGNC:23423};
GN Synonyms=PTPN20A, PTPN20B {ECO:0000312|HGNC:HGNC:23423};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12;
RP 13; 14 AND 15), ENZYME ACTIVITY, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=15790311; DOI=10.1042/bj20041932;
RA Fodero-Tavoletti M.T., Hardy M.P., Cornell B., Katsis F., Sadek C.M.,
RA Mitchell C.A., Kemp B.E., Tiganis T.;
RT "Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin
RT polymerization.";
RL Biochem. J. 389:343-354(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC TISSUE=Heart, and Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Tyrosine-protein phosphatase targeted to sites of actin
CC polymerization in response of varied extracellular stimuli. Has
CC tyrosine phosphatase activity towards various tyrosyl phosphorylated
CC substrates.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10044, ECO:0000269|PubMed:15790311};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15790311}. Cytoplasm
CC {ECO:0000269|PubMed:15790311}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000269|PubMed:15790311}.
CC Note=Colocalizes with the microtubule-organizing center and
CC intracellular membrane compartments.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=15;
CC Name=1;
CC IsoId=Q4JDL3-1; Sequence=Displayed;
CC Name=2; Synonyms=Variant 1;
CC IsoId=Q4JDL3-2; Sequence=VSP_027066;
CC Name=3; Synonyms=Variant 10;
CC IsoId=Q4JDL3-3; Sequence=VSP_027065;
CC Name=4; Synonyms=Variant 12;
CC IsoId=Q4JDL3-4; Sequence=VSP_027064;
CC Name=5; Synonyms=Variant 13;
CC IsoId=Q4JDL3-5; Sequence=VSP_027064, VSP_027070;
CC Name=6; Synonyms=Variant 3;
CC IsoId=Q4JDL3-6; Sequence=VSP_027063, VSP_027071;
CC Name=7; Synonyms=Variant 7;
CC IsoId=Q4JDL3-7; Sequence=VSP_027072, VSP_027073;
CC Name=8; Synonyms=Variant 4;
CC IsoId=Q4JDL3-8; Sequence=VSP_027066, VSP_027072, VSP_027073;
CC Name=9; Synonyms=Variant 18;
CC IsoId=Q4JDL3-9; Sequence=VSP_027064, VSP_038003, VSP_038004;
CC Name=10; Synonyms=Variant 8;
CC IsoId=Q4JDL3-10; Sequence=VSP_027069;
CC Name=11; Synonyms=Variant 2;
CC IsoId=Q4JDL3-11; Sequence=VSP_027066, VSP_027070;
CC Name=12; Synonyms=Variant 11;
CC IsoId=Q4JDL3-12; Sequence=VSP_027065, VSP_027072, VSP_027073;
CC Name=13; Synonyms=Variant 9;
CC IsoId=Q4JDL3-13; Sequence=VSP_027067, VSP_027068;
CC Name=14; Synonyms=Variant 14;
CC IsoId=Q4JDL3-14; Sequence=VSP_027064, VSP_027072, VSP_027073;
CC Name=15; Synonyms=Variant 5;
CC IsoId=Q4JDL3-15; Sequence=VSP_027066, VSP_027067, VSP_027068;
CC -!- TISSUE SPECIFICITY: Present in many cell lines (at protein level).
CC Widely expressed. {ECO:0000269|PubMed:15790311}.
CC -!- MISCELLANEOUS: [Isoform 9]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAW28797.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AY704141; AAW28780.1; -; mRNA.
DR EMBL; AY704142; AAW28781.1; -; mRNA.
DR EMBL; AY704143; AAW28782.1; -; mRNA.
DR EMBL; AY704144; AAW28783.1; -; mRNA.
DR EMBL; AY704145; AAW28784.1; -; mRNA.
DR EMBL; AY704146; AAW28785.1; -; mRNA.
DR EMBL; AY704147; AAW28786.1; -; mRNA.
DR EMBL; AY704148; AAW28787.1; -; mRNA.
DR EMBL; AY704149; AAW28788.1; -; mRNA.
DR EMBL; AY704150; AAW28789.1; -; mRNA.
DR EMBL; AY704151; AAW28790.1; -; mRNA.
DR EMBL; AY704152; AAW28791.1; -; mRNA.
DR EMBL; AY704153; AAW28792.1; -; mRNA.
DR EMBL; AY704154; AAW28793.1; -; mRNA.
DR EMBL; AY704158; AAW28797.1; ALT_SEQ; mRNA.
DR EMBL; AY753191; AAW88572.1; -; mRNA.
DR EMBL; AL450334; CAI15685.1; -; Genomic_DNA.
DR EMBL; AL672108; CAI15685.1; JOINED; Genomic_DNA.
DR EMBL; AL358791; CAI14088.1; -; Genomic_DNA.
DR EMBL; BX005072; CAI14088.1; JOINED; Genomic_DNA.
DR EMBL; AL358791; CAI14090.1; -; Genomic_DNA.
DR EMBL; BX005072; CAI14090.1; JOINED; Genomic_DNA.
DR EMBL; AL672108; CAI12200.1; -; Genomic_DNA.
DR EMBL; AL450334; CAI12200.1; JOINED; Genomic_DNA.
DR EMBL; BX005072; CAI23640.1; -; Genomic_DNA.
DR EMBL; AL358791; CAI23640.1; JOINED; Genomic_DNA.
DR EMBL; BX005072; CAI23642.1; -; Genomic_DNA.
DR EMBL; AL358791; CAI23642.1; JOINED; Genomic_DNA.
DR EMBL; BC093750; AAH93750.1; -; mRNA.
DR EMBL; BC113473; AAI13474.1; -; mRNA.
DR EMBL; BC143394; AAI43395.1; -; mRNA.
DR EMBL; BC171725; AAI71725.1; -; mRNA.
DR CCDS; CCDS73105.1; -. [Q4JDL3-2]
DR CCDS; CCDS73106.1; -. [Q4JDL3-8]
DR CCDS; CCDS73107.1; -. [Q4JDL3-11]
DR CCDS; CCDS73108.1; -. [Q4JDL3-15]
DR CCDS; CCDS73109.1; -. [Q4JDL3-6]
DR CCDS; CCDS73110.1; -. [Q4JDL3-1]
DR CCDS; CCDS73111.1; -. [Q4JDL3-7]
DR CCDS; CCDS73114.1; -. [Q4JDL3-4]
DR CCDS; CCDS73115.1; -. [Q4JDL3-14]
DR CCDS; CCDS81454.1; -. [Q4JDL3-10]
DR CCDS; CCDS81456.1; -. [Q4JDL3-5]
DR CCDS; CCDS86087.1; -. [Q4JDL3-13]
DR RefSeq; NP_001035816.1; NM_001042357.4. [Q4JDL3-1]
DR RefSeq; NP_001035817.1; NM_001042358.4. [Q4JDL3-2]
DR RefSeq; NP_001035818.1; NM_001042359.3. [Q4JDL3-11]
DR RefSeq; NP_001035819.1; NM_001042360.3. [Q4JDL3-6]
DR RefSeq; NP_001035820.1; NM_001042361.4. [Q4JDL3-8]
DR RefSeq; NP_001035821.1; NM_001042362.3. [Q4JDL3-15]
DR RefSeq; NP_001035822.1; NM_001042363.4. [Q4JDL3-4]
DR RefSeq; NP_001035823.1; NM_001042364.4. [Q4JDL3-14]
DR RefSeq; NP_001307610.1; NM_001320681.1. [Q4JDL3-4]
DR RefSeq; NP_001307611.1; NM_001320682.1.
DR RefSeq; NP_001307612.1; NM_001320683.1. [Q4JDL3-7]
DR RefSeq; NP_001307613.1; NM_001320684.1. [Q4JDL3-10]
DR RefSeq; NP_001307614.1; NM_001320685.1. [Q4JDL3-3]
DR RefSeq; NP_001307615.1; NM_001320686.1. [Q4JDL3-4]
DR RefSeq; NP_001307617.1; NM_001320688.1. [Q4JDL3-5]
DR RefSeq; NP_001307618.1; NM_001320689.1.
DR RefSeq; NP_001307619.1; NM_001320690.1.
DR RefSeq; NP_001307620.1; NM_001320691.1.
DR RefSeq; NP_056420.3; NM_015605.8. [Q4JDL3-7]
DR RefSeq; XP_011537907.1; XM_011539605.2. [Q4JDL3-1]
DR RefSeq; XP_011537908.1; XM_011539606.2. [Q4JDL3-1]
DR RefSeq; XP_011537909.1; XM_011539607.2. [Q4JDL3-1]
DR RefSeq; XP_011537912.1; XM_011539610.2. [Q4JDL3-4]
DR RefSeq; XP_016871533.1; XM_017016044.1.
DR RefSeq; XP_016871542.1; XM_017016053.1. [Q4JDL3-10]
DR RefSeq; XP_016871543.1; XM_017016054.1.
DR RefSeq; XP_016871546.1; XM_017016057.1.
DR RefSeq; XP_016871547.1; XM_017016058.1.
DR RefSeq; XP_016871548.1; XM_017016059.1.
DR RefSeq; XP_016871549.1; XM_017016060.1.
DR AlphaFoldDB; Q4JDL3; -.
DR SMR; Q4JDL3; -.
DR BioGRID; 117546; 30.
DR IntAct; Q4JDL3; 2.
DR MINT; Q4JDL3; -.
DR STRING; 9606.ENSP00000363459; -.
DR DEPOD; PTPN20; -.
DR iPTMnet; Q4JDL3; -.
DR PhosphoSitePlus; Q4JDL3; -.
DR BioMuta; PTPN20; -.
DR DMDM; 121944218; -.
DR MassIVE; Q4JDL3; -.
DR PaxDb; Q4JDL3; -.
DR PeptideAtlas; Q4JDL3; -.
DR PRIDE; Q4JDL3; -.
DR ProteomicsDB; 62174; -. [Q4JDL3-1]
DR ProteomicsDB; 62175; -. [Q4JDL3-10]
DR ProteomicsDB; 62178; -. [Q4JDL3-13]
DR ProteomicsDB; 62186; -. [Q4JDL3-7]
DR ProteomicsDB; 62188; -. [Q4JDL3-9]
DR Antibodypedia; 66300; 90 antibodies from 17 providers.
DR DNASU; 26095; -.
DR Ensembl; ENST00000374218.6; ENSP00000363335.2; ENSG00000204179.11. [Q4JDL3-4]
DR Ensembl; ENST00000374339.5; ENSP00000363459.3; ENSG00000204179.11. [Q4JDL3-1]
DR Ensembl; ENST00000374346.7; ENSP00000363466.3; ENSG00000204179.11. [Q4JDL3-7]
DR Ensembl; ENST00000395721.6; ENSP00000379071.2; ENSG00000204179.11. [Q4JDL3-4]
DR Ensembl; ENST00000395725.7; ENSP00000379075.3; ENSG00000204179.11. [Q4JDL3-14]
DR Ensembl; ENST00000395727.6; ENSP00000379077.2; ENSG00000204179.11. [Q4JDL3-6]
DR Ensembl; ENST00000502254.5; ENSP00000421404.1; ENSG00000204179.11. [Q4JDL3-13]
DR Ensembl; ENST00000502705.5; ENSP00000420995.1; ENSG00000204179.11. [Q4JDL3-10]
DR Ensembl; ENST00000503851.5; ENSP00000427676.1; ENSG00000204179.11. [Q4JDL3-15]
DR Ensembl; ENST00000505814.5; ENSP00000426355.1; ENSG00000204179.11. [Q4JDL3-4]
DR Ensembl; ENST00000506080.5; ENSP00000421921.2; ENSG00000204179.11. [Q4JDL3-4]
DR Ensembl; ENST00000508602.5; ENSP00000424491.2; ENSG00000204179.11. [Q4JDL3-14]
DR Ensembl; ENST00000509599.5; ENSP00000425012.1; ENSG00000204179.11. [Q4JDL3-7]
DR Ensembl; ENST00000509774.5; ENSP00000425362.1; ENSG00000204179.11. [Q4JDL3-8]
DR Ensembl; ENST00000509900.5; ENSP00000423819.1; ENSG00000204179.11. [Q4JDL3-14]
DR Ensembl; ENST00000510335.5; ENSP00000421453.1; ENSG00000204179.11. [Q4JDL3-9]
DR Ensembl; ENST00000511769.5; ENSP00000424283.1; ENSG00000204179.11. [Q4JDL3-2]
DR Ensembl; ENST00000513156.5; ENSP00000425912.1; ENSG00000204179.11. [Q4JDL3-11]
DR Ensembl; ENST00000513266.5; ENSP00000422839.1; ENSG00000204179.11. [Q4JDL3-5]
DR GeneID; 26095; -.
DR KEGG; hsa:26095; -.
DR MANE-Select; ENST00000374339.5; ENSP00000363459.3; NM_001042357.5; NP_001035816.1.
DR UCSC; uc001jdb.2; human. [Q4JDL3-1]
DR CTD; 26095; -.
DR DisGeNET; 26095; -.
DR GeneCards; PTPN20; -.
DR HGNC; HGNC:23423; PTPN20.
DR HPA; ENSG00000204179; Tissue enhanced (brain).
DR MIM; 610630; gene.
DR neXtProt; NX_Q4JDL3; -.
DR OpenTargets; ENSG00000204179; -.
DR VEuPathDB; HostDB:ENSG00000204179; -.
DR eggNOG; KOG0789; Eukaryota.
DR GeneTree; ENSGT00940000160066; -.
DR InParanoid; Q4JDL3; -.
DR OMA; HILYSDW; -.
DR PhylomeDB; Q4JDL3; -.
DR TreeFam; TF315573; -.
DR PathwayCommons; Q4JDL3; -.
DR Reactome; R-HSA-9008059; Interleukin-37 signaling.
DR SignaLink; Q4JDL3; -.
DR BioGRID-ORCS; 26095; 36 hits in 990 CRISPR screens.
DR ChiTaRS; PTPN20; human.
DR GenomeRNAi; 26095; -.
DR Pharos; Q4JDL3; Tdark.
DR PRO; PR:Q4JDL3; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q4JDL3; protein.
DR Bgee; ENSG00000204179; Expressed in pons and 134 other tissues.
DR ExpressionAtlas; Q4JDL3; baseline and differential.
DR GO; GO:0034451; C:centriolar satellite; IDA:HPA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Cytoskeleton; Hydrolase; Microtubule;
KW Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome.
FT CHAIN 1..420
FT /note="Tyrosine-protein phosphatase non-receptor type 20"
FT /id="PRO_0000295755"
FT DOMAIN 159..412
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 353
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160,
FT ECO:0000255|PROSITE-ProRule:PRU10044"
FT BINDING 323
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 353..359
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 397
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1L1L3"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A1L1L3"
FT VAR_SEQ 1..192
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027063"
FT VAR_SEQ 1..81
FT /note="Missing (in isoform 4, isoform 5, isoform 9 and
FT isoform 14)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027064"
FT VAR_SEQ 1..43
FT /note="MSSPRDFRAEPVNDYEGNDSEAEDLNFRETLPSSSQENTPRSK -> MGTTC
FT LHLGTLEQSL (in isoform 3 and isoform 12)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027065"
FT VAR_SEQ 1..11
FT /note="MSSPRDFRAEP -> MI (in isoform 2, isoform 8, isoform
FT 11 and isoform 15)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027066"
FT VAR_SEQ 114..145
FT /note="DTRKIVSEGELDQLAQIRPLIFNFHEQTAIKD -> VQHHGYSGPNERTTFW
FT HGSNEGAVSLLLRYCA (in isoform 13 and isoform 15)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027067"
FT VAR_SEQ 146..420
FT /note="Missing (in isoform 13 and isoform 15)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027068"
FT VAR_SEQ 165..378
FT /note="Missing (in isoform 10)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027069"
FT VAR_SEQ 165..306
FT /note="Missing (in isoform 5 and isoform 11)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027070"
FT VAR_SEQ 165..185
FT /note="ALELKNLPGEFNSGNQPSNRE -> MIQHAFLLEKARTTSMLVILE (in
FT isoform 9)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_038003"
FT VAR_SEQ 186..420
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_038004"
FT VAR_SEQ 193..195
FT /note="LPY -> MID (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15790311"
FT /id="VSP_027071"
FT VAR_SEQ 195..226
FT /note="YDSTRVPLGKSKDYINASYIRIVNCGEEYFYI -> FQHHGYSGPNERTTFW
FT HGSNEGAVSLLLRYCA (in isoform 7, isoform 8, isoform 12 and
FT isoform 14)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15790311"
FT /id="VSP_027072"
FT VAR_SEQ 227..420
FT /note="Missing (in isoform 7, isoform 8, isoform 12 and
FT isoform 14)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:15790311"
FT /id="VSP_027073"
SQ SEQUENCE 420 AA; 48423 MW; F3A1C8041ACB710E CRC64;
MSSPRDFRAE PVNDYEGNDS EAEDLNFRET LPSSSQENTP RSKVFENKVN SEKVKLSLRN
FPHNDYEDVF EEPSESGSDP SMWTARGPFR RDRWSSEDEE AAGPSQALSP LLSDTRKIVS
EGELDQLAQI RPLIFNFHEQ TAIKDCLKIL EEKTAAYDIM QEFMALELKN LPGEFNSGNQ
PSNREKNRYR DILPYDSTRV PLGKSKDYIN ASYIRIVNCG EEYFYIATQG PLLSTIDDFW
QMVLENNSNV IAMITREIEG GIIKCYHYWP ISLKKPLELK HFRVFLENYQ ILQYFIIRMF
QVVEKSTGTS HSVKQLQFTK WPDHGTPASA DSFIKYIRYA RKSHLTGPMV VHCSAGIGRT
GVFLCVDVVF CAIVKNCSFN IMDIVAQMRE QRSGMVQTKE QYHFCYDIVL EVLRKLLTLD
