PTN9_RAT
ID PTN9_RAT Reviewed; 593 AA.
AC Q641Z2; Q8K3Y9;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Tyrosine-protein phosphatase non-receptor type 9;
DE EC=3.1.3.48;
GN Name=Ptpn9;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 532-593.
RC STRAIN=Wistar;
RA Heneberg P., Draber P.;
RL Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Protein-tyrosine phosphatase that could participate in the
CC transfer of hydrophobic ligands or in functions of the Golgi apparatus.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10044};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class 3 subfamily. {ECO:0000305}.
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DR EMBL; BC082041; AAH82041.1; -; mRNA.
DR EMBL; AF520784; AAM98071.1; -; mRNA.
DR RefSeq; NP_001013058.1; NM_001013040.1.
DR AlphaFoldDB; Q641Z2; -.
DR SMR; Q641Z2; -.
DR IntAct; Q641Z2; 2.
DR MINT; Q641Z2; -.
DR STRING; 10116.ENSRNOP00000023831; -.
DR iPTMnet; Q641Z2; -.
DR PhosphoSitePlus; Q641Z2; -.
DR jPOST; Q641Z2; -.
DR PaxDb; Q641Z2; -.
DR Ensembl; ENSRNOT00000023831; ENSRNOP00000023831; ENSRNOG00000017600.
DR GeneID; 266611; -.
DR KEGG; rno:266611; -.
DR UCSC; RGD:628726; rat.
DR CTD; 5780; -.
DR RGD; 628726; Ptpn9.
DR eggNOG; ENOG502QR81; Eukaryota.
DR GeneTree; ENSGT00940000157447; -.
DR InParanoid; Q641Z2; -.
DR OMA; QWTGHPQ; -.
DR OrthoDB; 411281at2759; -.
DR PhylomeDB; Q641Z2; -.
DR TreeFam; TF351975; -.
DR PRO; PR:Q641Z2; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000017600; Expressed in stomach and 19 other tissues.
DR ExpressionAtlas; Q641Z2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0044306; C:neuron projection terminus; ISO:RGD.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD.
DR GO; GO:0010977; P:negative regulation of neuron projection development; ISO:RGD.
DR GO; GO:0035335; P:peptidyl-tyrosine dephosphorylation; ISO:RGD.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; ISO:RGD.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Hydrolase; Protein phosphatase; Reference proteome.
FT CHAIN 1..593
FT /note="Tyrosine-protein phosphatase non-receptor type 9"
FT /id="PRO_0000094766"
FT DOMAIN 84..243
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT DOMAIN 303..574
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 515
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160,
FT ECO:0000255|PROSITE-ProRule:PRU10044"
FT BINDING 470
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 515..521
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 559
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P43378"
SQ SEQUENCE 593 AA; 67962 MW; 377836BB6B10D33D CRC64;
MEPATAPRPD MAPELTPEEE QATKQFLEEI NKWTVQYNVS PLSWNVAVKF LMARKFDVLR
AVELFHCYRE TRRKEGIVKL KPHEEPLRSE ILSGKFTILN VRDPTGASIA LFTARLHHPH
KSVQHVVLQA LFYLLDRAVD SFETQRNGLV FIYDMCGSNY ANFELDLGKK VLNLLKGAFP
ARLKKVLIVG APIWFRVPYS IISLLLKDKV RERIQILKTS EVTQHLPREC LPENLGGYIK
IDLATWNFQF LPQVNGHPDP FDEIILFSLP PALDWDSVHV PGPHAMTIQE LVDYVNTRQK
QGIYEEYEDI RRENPVGTFH CSMSPGNLEK NRYGDVPCLD QTRVKLTKRS GHTQTDYINA
SFMDGYKQKN AYIGTQGPLE NTYRDFWLMV WEQKVLVIVM TTRFEEGGRR KCGQYWPLEK
DSRIQFGFLT VTNLGVENMN HYKKTTLEIH NTEERQKRQV THFQFLSWPD YGVPSSAASL
IDFLRVVRSQ QSMAVGSLGA RSKGQCPEPP IVVHCSAGIG RTGTFCSLDI CLAQLEELGT
LNVFQTVSRM RTQRAFSIQT PEQYYFCYKA ILEFAEREGM VPSGHSLLAM DGQ
