ID   PTOV1_BOVIN             Reviewed;         415 AA.
AC   A4IFC9;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Prostate tumor-overexpressed gene 1 protein homolog;
GN   Name=PTOV1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May activate transcription. Required for nuclear
CC       translocation of FLOT1. Promotes cell proliferation.
CC       {ECO:0000250|UniProtKB:Q86YD1}.
CC   -!- SUBUNIT: May interact with CREBBP. Interacts with FLOT1.
CC       {ECO:0000250|UniProtKB:Q86YD1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86YD1}. Nucleus
CC       {ECO:0000250|UniProtKB:Q86YD1}. Cell membrane
CC       {ECO:0000250|UniProtKB:Q86YD1}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q86YD1}. Note=Translocates from the cytoplasm to
CC       the nucleus at the onset of S-phase. Also localizes to lipid rafts.
CC       {ECO:0000250|UniProtKB:Q86YD1}.
CC   -!- PTM: Ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the
CC       diglycine (Gly-Gly) at the C-terminus, leading to its degradation.
CC       Ubiquitinated by the CRL2(APPBP2) complex, which recognizes the Arg-
CC       Xaa-Xaa-Gly sequence at the C-terminus, leading to its degradation.
CC       {ECO:0000250|UniProtKB:Q86YD1}.
CC   -!- SIMILARITY: Belongs to the Mediator complex subunit 25 family. PTOV1
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: Despite sequence similarity to MED25, to date this protein has
CC       not been identified as a component of the Mediator complex.
CC       {ECO:0000305}.
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DR   EMBL; BC134519; AAI34520.1; -; mRNA.
DR   RefSeq; NP_001077249.1; NM_001083780.1.
DR   AlphaFoldDB; A4IFC9; -.
DR   SMR; A4IFC9; -.
DR   STRING; 9913.ENSBTAP00000026147; -.
DR   PaxDb; A4IFC9; -.
DR   PRIDE; A4IFC9; -.
DR   Ensembl; ENSBTAT00000026147; ENSBTAP00000026147; ENSBTAG00000030578.
DR   GeneID; 617775; -.
DR   KEGG; bta:617775; -.
DR   CTD; 53635; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030578; -.
DR   VGNC; VGNC:33522; PTOV1.
DR   eggNOG; ENOG502SS25; Eukaryota.
DR   GeneTree; ENSGT00940000161923; -.
DR   HOGENOM; CLU_045342_0_0_1; -.
DR   InParanoid; A4IFC9; -.
DR   OMA; ELDCLTH; -.
DR   OrthoDB; 340324at2759; -.
DR   TreeFam; TF329598; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000030578; Expressed in retina and 107 other tissues.
DR   ExpressionAtlas; A4IFC9; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.40.290.30; -; 2.
DR   InterPro; IPR045105; Med25/PTOV1.
DR   InterPro; IPR021394; Med25_PTOV.
DR   InterPro; IPR038196; Med25_PTOV_sf.
DR   PANTHER; PTHR12433; PTHR12433; 2.
DR   Pfam; PF11232; Med25; 2.
PE   2: Evidence at transcript level;
KW   Activator; Cell membrane; Cytoplasm; Membrane; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..415
FT                   /note="Prostate tumor-overexpressed gene 1 protein homolog"
FT                   /id="PRO_0000304964"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..415
FT                   /note="Interaction with FLOT1"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91VU8"
SQ   SEQUENCE   415 AA;  46683 MW;  E59F5D9CA6364568 CRC64;
     MVRPRRAPHR SGAGGPLGGR GRPLRPFTAR AARSRSWPAS PRGPQPPRIR ARSAPPMQGA
     RVFGALGPIG PSSPGLALGG LAVGEHRLSN KLLAWSGVLE WQEKRRPYSD STAKLKRALP
     CQAYVNQGEN LETDQWPQKL IMQLIPQQLL TTLGPLFRNS QLAQFHFTNR DCDSLKGLCR
     VMGNGFAGCM LFPHISPCEV RVLMLLYSSK KKIFMGLIPY DQSGFVNAIR QVITTRKQAV
     GPGGVAGPVQ IVNNKFLAWS GVMEWQEPRP EPHSRSKRWL PSHIYVNQGE ILRTEQWPRK
     LYMQLIPQQL LTTLVPLFRN SRLVQFHFTK DLETLKSLCR IMDNGFAGCV HFSYKASCEV
     RVLMLLYSSE KKIFIGLIPH DQSNFVNGIR RVIANQQQVL QRNLEQEQQQ RGMGG