PTOV1_DROME
ID PTOV1_DROME Reviewed; 364 AA.
AC Q9VCB1;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein PTOV1 homolog;
GN ORFNames=CG13609;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 25 family. PTOV1
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: Despite sequence similarity to MED25, to date this protein has
CC not been identified as a component of the Mediator complex.
CC {ECO:0000305}.
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DR EMBL; AE014297; AAF56262.1; -; Genomic_DNA.
DR EMBL; BT023259; AAY55675.1; -; mRNA.
DR RefSeq; NP_651233.1; NM_142976.5.
DR AlphaFoldDB; Q9VCB1; -.
DR SMR; Q9VCB1; -.
DR BioGRID; 67814; 3.
DR IntAct; Q9VCB1; 3.
DR STRING; 7227.FBpp0083945; -.
DR PaxDb; Q9VCB1; -.
DR DNASU; 42883; -.
DR EnsemblMetazoa; FBtr0084560; FBpp0083945; FBgn0039170.
DR GeneID; 42883; -.
DR KEGG; dme:Dmel_CG13609; -.
DR UCSC; CG13609-RA; d. melanogaster.
DR FlyBase; FBgn0039170; CG13609.
DR VEuPathDB; VectorBase:FBgn0039170; -.
DR eggNOG; ENOG502QRN5; Eukaryota.
DR GeneTree; ENSGT00940000168585; -.
DR HOGENOM; CLU_045342_0_0_1; -.
DR InParanoid; Q9VCB1; -.
DR OMA; ELDCLTH; -.
DR OrthoDB; 340324at2759; -.
DR PhylomeDB; Q9VCB1; -.
DR BioGRID-ORCS; 42883; 0 hits in 3 CRISPR screens.
DR ChiTaRS; CG13609; fly.
DR GenomeRNAi; 42883; -.
DR PRO; PR:Q9VCB1; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039170; Expressed in cleaving embryo and 14 other tissues.
DR Genevisible; Q9VCB1; DM.
DR GO; GO:0016592; C:mediator complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.40.290.30; -; 2.
DR InterPro; IPR045105; Med25/PTOV1.
DR InterPro; IPR021394; Med25_PTOV.
DR InterPro; IPR038196; Med25_PTOV_sf.
DR PANTHER; PTHR12433; PTHR12433; 2.
DR Pfam; PF11232; Med25; 2.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..364
FT /note="Protein PTOV1 homolog"
FT /id="PRO_0000304968"
FT REGION 187..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 40510 MW; 8AFB96AACCE2230D CRC64;
MEPVPEEARG VGDDEGELDC LTHMIGALLL QKEPENPENG DSKETIWSGE LEWEDAQILD
QPKTLHTVQC KICSMVKEGQ PEINTENWPN KLKTQLIPKK VLGKIGEQFL KDARMVVFRS
SQGEVLNLLI TAMSSGFAGC IHFPSNPNCN IKALILIYSR DHQALVGFIP NNEDSFSERL
QEILQGAKRK PGVKTPKQPQ PEEPPPVEED AIINELLWTG SLNWSTQASL EEPSISHKLE
CSVYIAIKNG DPGISAEDWP TDMPMVLMPS IYLGQFAGAF IKDSKLIILR STPGEEHDSL
ASSMSAGSCG CARFSSEVVC KVIMLLYSSP RNAFLGFIPR DQANFVKRLR EVLDEHRQKA
RNKE
