ID   PTP18_STYPL             Reviewed;         115 AA.
AC   P28210;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Tyrosine-protein phosphatase 18;
DE            EC=3.1.3.48;
DE   Flags: Fragment;
GN   Name=STY-18;
OS   Styela plicata (Wrinkled sea squirt) (Ascidia plicata).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Styelidae; Styela.
OX   NCBI_TaxID=7726;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1704870; DOI=10.1007/bf00211693;
RA   Matthews R.J., Flores E., Thomas M.L.;
RT   "Protein tyrosine phosphatase domains from the protochordate Styela
RT   plicata.";
RL   Immunogenetics 33:33-41(1991).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10044};
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       {ECO:0000305}.
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DR   EMBL; M38003; AAA29836.1; -; mRNA.
DR   AlphaFoldDB; P28210; -.
DR   SMR; P28210; -.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase.
FT   CHAIN           <1..>115
FT                   /note="Tyrosine-protein phosphatase 18"
FT                   /id="PRO_0000094906"
FT   DOMAIN          <1..>115
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   BINDING         83
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
FT   NON_TER         115
SQ   SEQUENCE   115 AA;  13577 MW;  727E14A73667A001 CRC64;
     WLMIVEQKCR VIVMLAKCFE AGKKKCQKYW PDSKETKAFG RVTVFNAEEV KYCGFIRRRF
     RIESVDKVLS MEVFQYQYIN WPDHSVPNTT SNLVRMHKYV IQCLEETGSD APMVV