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PTP1_ENCCU
ID   PTP1_ENCCU              Reviewed;         395 AA.
AC   O76942; Q964G9; Q964H0; Q964H1;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Polar tube protein 1;
DE   AltName: Full=Major polar tube protein;
DE            Short=Major PTP;
DE   Flags: Precursor;
GN   Name=PTP1; OrderedLocusNames=ECU06_0250;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-42 AND 351-365,
RP   AND CHARACTERIZATION.
RX   PubMed=9723921; DOI=10.1046/j.1365-2958.1998.00975.x;
RA   Delbac F., Peyret P., Metenier G., David D., Danchin A., Vivares C.P.;
RT   "On proteins of the microsporidian invasive apparatus: complete sequence of
RT   a polar tube protein of Encephalitozoon cuniculi.";
RL   Mol. Microbiol. 29:825-834(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-349.
RC   STRAIN=CDC:V282, CDC:V385, and m104;
RX   PubMed=11376065; DOI=10.1128/jcm.39.6.2248-2253.2001;
RA   Xiao L., Li L., Visvesvara G.S., Moura H., Didier E.S., Lal A.A.;
RT   "Genotyping Encephalitozoon cuniculi by multilocus analyses of genes with
RT   repetitive sequences.";
RL   J. Clin. Microbiol. 39:2248-2253(2001).
RN   [4]
RP   INTERACTION WITH PTP2 AND PTP3.
RX   PubMed=12076771; DOI=10.1016/s0166-6851(02)00073-7;
RA   Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.;
RT   "The microsporidian polar tube: evidence for a third polar tube protein
RT   (PTP3) in Encephalitozoon cuniculi.";
RL   Mol. Biochem. Parasitol. 122:69-80(2002).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Involved with PTP2 and PTP3 in the formation of the polar
CC       tube through which the infectious agent is passed on to the host cell.
CC       Accounts for at least 70 percent of the mass of the polar tube.
CC   -!- SUBUNIT: Interacts with PTP2 and PTP3. {ECO:0000269|PubMed:12076771}.
CC   -!- SUBCELLULAR LOCATION: Spore polar tube.
CC   -!- DEVELOPMENTAL STAGE: Found in spores. Expression is high during polar
CC       tube formation. {ECO:0000269|PubMed:16691553}.
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DR   EMBL; AJ005666; CAA06662.1; -; Genomic_DNA.
DR   EMBL; AL590446; CAD25385.1; -; Genomic_DNA.
DR   EMBL; AF310677; AAK62814.1; -; Genomic_DNA.
DR   EMBL; AF310678; AAK62815.1; -; Genomic_DNA.
DR   EMBL; AF310679; AAK62816.1; -; Genomic_DNA.
DR   RefSeq; NP_585781.1; NM_001041403.1.
DR   AlphaFoldDB; O76942; -.
DR   GeneID; 859204; -.
DR   KEGG; ecu:ECU06_0250; -.
DR   VEuPathDB; MicrosporidiaDB:ECU06_0250; -.
DR   HOGENOM; CLU_665687_0_0_1; -.
DR   OrthoDB; 1433130at2759; -.
DR   Proteomes; UP000000819; Chromosome VI.
DR   GO; GO:0044099; C:polar tube; IDA:CACAO.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Reference proteome; Repeat;
KW   Signal; Sporulation.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:9723921"
FT   CHAIN           23..395
FT                   /note="Polar tube protein 1"
FT                   /id="PRO_0000022181"
FT   REPEAT          179..204
FT                   /note="1"
FT   REPEAT          205..230
FT                   /note="2"
FT   REPEAT          231..256
FT                   /note="3"
FT   REPEAT          257..282
FT                   /note="4"
FT   REGION          59..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..282
FT                   /note="4 X 26 AA approximate tandem repeats"
FT   REGION          277..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..299
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        86
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        173
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         209..234
FT                   /note="Missing (in strain: CDC:V282)"
FT   VARIANT         210
FT                   /note="I -> V (in strain: m104)"
SQ   SEQUENCE   395 AA;  39609 MW;  8FB498209F5EA9B9 CRC64;
     MKGISKILSA SIALMKLENV YSATALCSNA YGLTPGQQGM AQQPSYVLIP STPGTIANCA
     SGSQDTYSPS PAAPTSPVTP GKTSENETSP SAPAEDVGTC KIAVLKHCDA PGTTSGTTPG
     SGPCETPEQQ QPLSVISTTP AVPVTVESAQ SPSVVPVVPV VAHHQAVPGY YNNGTSGIPG
     QQQILSGTLP PGATLCQGQA MPSTPGQQQI LSGTLPPGVT LCQGQATPST PGQQQVLSGT
     LPPGVTLCQG QATPSTPGQQ QVLSGTLLPG ATLCQDQGMP GTSGVPGQQG QSSGQCCAPQ
     IPNPVMPPSM NISGNGYPSS TAYSPNLGSL GSCVDIQKTG GTSCEQKPEK SATQYAMEAC
     ATPTPTVIIG NSEYLVGPGM YNAINSPCNT AVQCC
 
 
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