ID   PTP1_ENCIN              Reviewed;         371 AA.
AC   Q5F2J0;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Polar tube protein 1;
DE   AltName: Full=Major polar tube protein;
DE            Short=Major PTP;
DE   Flags: Precursor;
GN   Name=PTP1;
OS   Encephalitozoon intestinalis (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=58839;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11159998; DOI=10.1128/iai.69.2.1016-1024.2001;
RA   Delbac F., Peuvel I., Metenier G., Peyretaillade E., Vivares C.P.;
RT   "Microsporidian invasion apparatus: identification of a novel polar tube
RT   protein and evidence for clustering of ptp1 and ptp2 genes in three
RT   Encephalitozoon species.";
RL   Infect. Immun. 69:1016-1024(2001).
RN   [2]
RP   IDENTIFICATION AS AN ANTIGEN, AND GLYCOSYLATION.
RX   PubMed=16299281; DOI=10.1128/iai.73.12.7906-7913.2005;
RA   Peek R., Delbac F., Speijer D., Polonais V., Greve S., Wentink-Bonnema E.,
RA   Ringrose J., van Gool T.;
RT   "Carbohydrate moieties of microsporidian polar tube proteins are targeted
RT   by immunoglobulin G in immunocompetent individuals.";
RL   Infect. Immun. 73:7906-7913(2005).
CC   -!- FUNCTION: Involved with PTP2 and PTP3 in formation of a polar tube
CC       through which the infectious agent is passed on to the host cell.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Spore polar tube {ECO:0000250}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:16299281}.
CC   -!- MISCELLANEOUS: The host antibody response is directed against the post-
CC       translational carbohydrate modification.
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DR   EMBL; AX007051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJ880382; CAI54279.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5F2J0; -.
DR   VEuPathDB; MicrosporidiaDB:Eint_060150; -.
DR   GO; GO:0044099; C:polar tube; IEA:UniProtKB-SubCell.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Glycoprotein; Signal; Sporulation.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..371
FT                   /note="Polar tube protein 1"
FT                   /id="PRO_0000377522"
FT   REGION          65..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  37520 MW;  1A9733EB8B5B6625 CRC64;
     MKGISKVLSA SIVLMKLKGV YSTTVLCGDS TQGLQGTTQP SYVLVPSAPE TIANCGYSPQ
     NMYVPSTPTT MPSTVPGTTG ESETPTSPTS SPTEDVGTCK IAVVKHCDAP GTSSTPCEPE
     QTLAPSQPVA ATIATPLVVA SVQTPQAAVT ILTPKAVSAQ PATIISPFNQ APGYYNSAIP
     GQILTGNVLS PSASSCQVVP GTTGSSTPQQ LPGAVSSGTI PCQIVQGTQS SGNTPGQQFL
     PGIVPVGSLQ PDQATSGTPT PSVSQSQSGQ QCCCTPPITN PVMPTPMGIS SNGYPSSTAY
     APTLGQLGPC IDTQKSTSSC EPKEKPVAQY GMEACAAPTP TAVLGNAEYL LSPGMYNSLN
     SPCNACCQQQ C