ID   PTP1_NPVOP              Reviewed;         220 AA.
AC   O10274;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Putative tyrosine-protein phosphatase 1;
DE            Short=Protein-tyrosine phosphatase 1;
DE            EC=3.1.3.48;
GN   Name=PTP-1; ORFNames=ORF10;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Could be inactive as the active site cysteine is modified to
CC       tryptophan.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class CDC14 subfamily. {ECO:0000305}.
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DR   EMBL; U75930; AAC59009.1; -; Genomic_DNA.
DR   RefSeq; NP_046166.1; NC_001875.2.
DR   SMR; O10274; -.
DR   GeneID; 912096; -.
DR   KEGG; vg:912096; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   Pfam; PF00782; DSPc; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Protein phosphatase.
FT   CHAIN           1..220
FT                   /note="Putative tyrosine-protein phosphatase 1"
FT                   /id="PRO_0000094882"
FT   DOMAIN          67..218
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   SITE            162
FT                   /note="Equivalent of active site Cys"
SQ   SEQUENCE   220 AA;  25234 MW;  D3FC093F1953D425 CRC64;
     MLTSRRWAVI YTRTSERNCG GAWCTNGVRR RRQVHLPSVR ARAMFPDRWH EYTACGAVIE
     GTRLLCFKVP LNAELFEYVT SDEDRWTAAS VLARHSALGA VIDLTNTARY YDGAQMVKMG
     LLYKKIRVPG RAVPDDDIVA EFIETVDEFF RRCPTMLVAV HWTHGLNRSG YLVCRYMVER
     LGVSPTDAIA RFETARGHKI ERTNYLQDLL ARKHVRGQPN