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PTP2_DICDI
ID   PTP2_DICDI              Reviewed;         377 AA.
AC   P34138; Q54YM9;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Tyrosine-protein phosphatase 2;
DE            EC=3.1.3.48;
DE   AltName: Full=Protein-tyrosine-phosphate phosphohydrolase 2;
DE            Short=PTPA;
GN   Name=ptpB; Synonyms=ptp2; ORFNames=DDB_G0277865;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX4;
RX   PubMed=8226777; DOI=10.1016/s0021-9258(18)41581-5;
RA   Ramalingam R., Shaw D.R., Ennis H.;
RT   "Cloning and functional expression of a Dictyostelium discoideum protein
RT   tyrosine phosphatase.";
RL   J. Biol. Chem. 268:22680-22685(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC         ProRule:PRU10044};
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class subfamily. {ECO:0000305}.
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DR   EMBL; L15420; AAA33242.1; -; mRNA.
DR   EMBL; AAFI02000023; EAL68105.1; -; Genomic_DNA.
DR   PIR; A48711; A48711.
DR   RefSeq; XP_642173.1; XM_637081.1.
DR   AlphaFoldDB; P34138; -.
DR   SMR; P34138; -.
DR   STRING; 44689.DDB0214985; -.
DR   PaxDb; P34138; -.
DR   PRIDE; P34138; -.
DR   EnsemblProtists; EAL68105; EAL68105; DDB_G0277865.
DR   GeneID; 8621380; -.
DR   KEGG; ddi:DDB_G0277865; -.
DR   dictyBase; DDB_G0277865; ptpB.
DR   eggNOG; KOG0792; Eukaryota.
DR   HOGENOM; CLU_001645_9_1_1; -.
DR   InParanoid; P34138; -.
DR   OMA; KPKTGHE; -.
DR   PhylomeDB; P34138; -.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   PRO; PR:P34138; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016791; F:phosphatase activity; IDA:dictyBase.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IDA:dictyBase.
DR   GO; GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.
DR   GO; GO:0006470; P:protein dephosphorylation; IDA:dictyBase.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..377
FT                   /note="Tyrosine-protein phosphatase 2"
FT                   /id="PRO_0000094887"
FT   DOMAIN          27..347
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   REGION          77..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..91
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..122
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        281
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160,
FT                   ECO:0000255|PROSITE-ProRule:PRU10044"
SQ   SEQUENCE   377 AA;  43488 MW;  5B08F6EB54829FD9 CRC64;
     MDESFDAFEI KPNSSIIEHF NNHPTCIDKE FNFILQKTEL RALETDKFRS ALEAKNKLKN
     RYSNVLPFEE TRVKINIDDD DDDEDDNEDD IIVSNNNNNN NNNEKRIKRN SIGSSGQSDV
     MSNSSDEEDH GGSGDEGTTL SDYINASFIN NGTYICTQGP LLNTIVDFWK MIWEQNSNII
     VMLTREEENF KTKCDKYWPD KDEERYGNFI VKFDNNITIP DILIRREFTL ENLKDNKTRK
     IYHFQYTTWP DHGTPVSTTG FLKFVSFVDH EKRSGPIVVH CSAGIGRSGT FVAIHSIVAK
     FAKHYDEKKQ APSINLPKLV VEMRNERPGM VQTRDQYRFC YLAISEAMNT VLKKEQKKRK
     GLSYSYSSIP LTGPEHD
 
 
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