ID   PTP2_ENCCU              Reviewed;         277 AA.
AC   Q8SRT0;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Polar tube protein 2;
DE   Flags: Precursor;
GN   Name=PTP2; OrderedLocusNames=ECU06_0240;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 105-119, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=11159998; DOI=10.1128/iai.69.2.1016-1024.2001;
RA   Delbac F., Peuvel I., Metenier G., Peyretaillade E., Vivares C.P.;
RT   "Microsporidian invasion apparatus: identification of a novel polar tube
RT   protein and evidence for clustering of ptp1 and ptp2 genes in three
RT   Encephalitozoon species.";
RL   Infect. Immun. 69:1016-1024(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Vivares C.P., Danchin A., Delbac F.;
RT   "Microsporidium polar tube proteins, nucleic acids coding for said proteins
RT   and their uses.";
RL   Patent number WO0001724, 13-JAN-2000.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [4]
RP   INTERACTION WITH PTP1 AND PTP3.
RX   PubMed=12076771; DOI=10.1016/s0166-6851(02)00073-7;
RA   Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.;
RT   "The microsporidian polar tube: evidence for a third polar tube protein
RT   (PTP3) in Encephalitozoon cuniculi.";
RL   Mol. Biochem. Parasitol. 122:69-80(2002).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Involved in formation of a polar tube through which the
CC       infectious agent is passed on to the host cell.
CC   -!- SUBUNIT: Interacts with PTP1 and PTP3. {ECO:0000269|PubMed:12076771}.
CC   -!- SUBCELLULAR LOCATION: Spore polar tube {ECO:0000269|PubMed:11159998}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
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DR   EMBL; AX007050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL590446; CAD25384.1; -; Genomic_DNA.
DR   RefSeq; NP_585780.1; NM_001041402.1.
DR   AlphaFoldDB; Q8SRT0; -.
DR   GeneID; 859203; -.
DR   KEGG; ecu:ECU06_0240; -.
DR   VEuPathDB; MicrosporidiaDB:ECU06_0240; -.
DR   HOGENOM; CLU_1004828_0_0_1; -.
DR   InParanoid; Q8SRT0; -.
DR   OrthoDB; 1399114at2759; -.
DR   Proteomes; UP000000819; Chromosome VI.
DR   GO; GO:0044099; C:polar tube; IDA:CACAO.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR031507; PTP2.
DR   Pfam; PF17022; PTP2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Reference proteome; Repeat;
KW   Signal; Sporulation.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..277
FT                   /note="Polar tube protein 2"
FT                   /id="PRO_0000377525"
FT   REGION          237..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        237..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        134
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   277 AA;  30076 MW;  75FADFE9E706641E CRC64;
     MLLLLAITAV VSATMVHPSA VVPQPAAPLH VVPPQQQMGM VNGCTSKKLE GAEIMRRNMI
     ECQKRSSEAT KAMIERANEK AVESFNKEVS KGPSQKDGGQ CIEKAVQGTD RCILAGIIDK
     AVNKRKYRIS DVENSTSLYR GDKLIALIVN VDYGLQPITK PKKKKSKIMA NLPQPKREMY
     FNQIGQLVGA RGTFPQENKE DCKPCEGPKK TVETTSEKCN LGCELKGTSA LISKAIQKKE
     VKDTKEGEKS ASQDSDGEGT AEDAEVQQPS ADGEGLE