PTP2_NPVOP
ID PTP2_NPVOP Reviewed; 160 AA.
AC O10273;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Tyrosine-protein phosphatase 2;
DE EC=3.1.3.48;
DE AltName: Full=Protein-tyrosine phosphatase 2;
GN Name=PTP-2; ORFNames=ORF9;
OS Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=262177;
OH NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT polyhedrosis virus genome.";
RL Virology 229:381-399(1997).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10044};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class dual specificity subfamily. {ECO:0000305}.
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DR EMBL; U75930; AAC59008.1; -; Genomic_DNA.
DR RefSeq; NP_046165.1; NC_001875.2.
DR SMR; O10273; -.
DR GeneID; 912072; -.
DR KEGG; vg:912072; -.
DR Proteomes; UP000009248; Genome.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase; Protein phosphatase.
FT CHAIN 1..160
FT /note="Tyrosine-protein phosphatase 2"
FT /id="PRO_0000094883"
FT DOMAIN 3..154
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT ACT_SITE 96
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ SEQUENCE 160 AA; 17980 MW; 51DDA804A554301B CRC64;
MYEASQIDEH VFVGGYYGDN EAMLRFIENH AIASVISLID SDVAPIRHAL GLPVGDHIHV
YCEAAPTCAA LPNAMPALYD YMVRRIGEGK RVLVHCYAGA SRSAALAVYY LMRSRQMPYQ
DALNAVQSKR RVAINDHFVR FLATRCSYRF VNDELKPQIV