PTP8_STYPL
ID PTP8_STYPL Reviewed; 112 AA.
AC P28200;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Tyrosine-protein phosphatase 8;
DE EC=3.1.3.48;
DE Flags: Fragment;
GN Name=STY-8;
OS Styela plicata (Wrinkled sea squirt) (Ascidia plicata).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC Styelidae; Styela.
OX NCBI_TaxID=7726;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1704870; DOI=10.1007/bf00211693;
RA Matthews R.J., Flores E., Thomas M.L.;
RT "Protein tyrosine phosphatase domains from the protochordate Styela
RT plicata.";
RL Immunogenetics 33:33-41(1991).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE-
CC ProRule:PRU10044};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000305}.
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DR EMBL; M37993; AAA29826.1; -; mRNA.
DR AlphaFoldDB; P28200; -.
DR SMR; P28200; -.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR008356; Tyr_Pase_KIM-con.
DR PANTHER; PTHR46198; PTHR46198; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Protein phosphatase.
FT CHAIN <1..>112
FT /note="Tyrosine-protein phosphatase 8"
FT /id="PRO_0000094896"
FT DOMAIN <1..>112
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT NON_TER 1
FT NON_TER 112
SQ SEQUENCE 112 AA; 13173 MW; 3E78BB04A5B3EE40 CRC64;
ENSTAIVMIT KLKERKEKCS EYMPLKCGEK HTYENFEIEI KNVRNADHYT VRTIEVRNTE
EDNATHTVYH YWYAEWLDHD TPEKLRGLLT LIQEVGLRCP DIANSEYGPV VV