ID   PTPC1_BOVIN             Reviewed;         796 AA.
AC   A7E379;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Protein tyrosine phosphatase domain-containing protein 1;
DE            EC=3.1.3.-;
GN   Name=PTPDC1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-784.
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class PTPDC1 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI51751.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; AAFC03031364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151750; AAI51751.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001193525.1; NM_001206596.1.
DR   AlphaFoldDB; A7E379; -.
DR   SMR; A7E379; -.
DR   STRING; 9913.ENSBTAP00000007630; -.
DR   PaxDb; A7E379; -.
DR   GeneID; 519311; -.
DR   KEGG; bta:519311; -.
DR   CTD; 138639; -.
DR   eggNOG; KOG1720; Eukaryota.
DR   InParanoid; A7E379; -.
DR   OrthoDB; 828691at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Hydrolase; Phosphoprotein;
KW   Protein phosphatase; Reference proteome.
FT   CHAIN           1..796
FT                   /note="Protein tyrosine phosphatase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000312211"
FT   DOMAIN          126..297
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   ACT_SITE        234
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   MOD_RES         435
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2A3K4"
FT   MOD_RES         437
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A2A3K4"
SQ   SEQUENCE   796 AA;  89386 MW;  234A277107F903B3 CRC64;
     MQDPPRRLSA VPFLSSFFEG RRHSASDPIL RLQQGRRSSA AKVLSSSSLQ VMVAMSSVSC
     AERNPTCPER KRNSGRPTPK YTKVGERLRH VIPGHVACSM ACGGKACKYE NAARWSEQEQ
     AVKGIYSSWV TDNILAMARP STEVLEKFCI IEQFRSHGIK SIINLQRPGE HASCGNPLEQ
     ESGFTYLPEA FMEAGIYFYN FGWKDYGVAS LTTILDMVKV MTFALQEGKV AIHCHAGLGR
     TGVLIACYLV FATRMTADQA IIFVRAKRPN SIQTRGQLLC VREFTQFLIP LRNIFSCCDP
     KAHAVTLAQY LIRQRHLLHG YEARLLKHIP KIIHLVCKLL LDLAENRPVV TEVADIPGLS
     AEIEKTVSEM ITRQLDKELL RHDSDASDSF TPTAVVMDFE NQDVVLSSEQ ELDPLWKRRN
     VECLQPLAHL KRQLSYSDSD LKRAESLLEQ GRTPWTVPAQ ALLCHNPRQQ KHISRCYSPQ
     SPQLDLNKET LVRNTFSFWN HTKFGVPEGL KDDGSLIFHR TSIPKEVQRS RTFSSGISDS
     YNPGEPVTPN SANIPKGPNS SQQKVYHCEC ESHGGCGPSS VAEDGETCRR PVDCGSSPKA
     QFLGNETQNS KYLSEVAAHM PLQSELSVEA RRILAAKALA NLNEIAEKEE VKKKVEMWQK
     ELNSRDGAWE RICGEKDPFI LCSLMWSWVE QLKEPVITKE DMDMLVDRCA DASEALFLLE
     KGQQQTILCV LHCIVSLQTI PADVEEAVLA RAIKAFTKVN FDSENGPIVY NTLKKIFKRT
     LEEKRKMTKD NPEPGI