ID   PTPC1_DANRE             Reviewed;         713 AA.
AC   A1L1R5;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein tyrosine phosphatase domain-containing protein 1;
DE            EC=3.1.3.-;
GN   Name=ptpdc1; ORFNames=zgc:158271;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC       receptor class PTPDC1 subfamily. {ECO:0000305}.
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DR   EMBL; BC129183; AAI29184.1; -; mRNA.
DR   EMBL; BC131875; AAI31876.1; -; mRNA.
DR   AlphaFoldDB; A1L1R5; -.
DR   SMR; A1L1R5; -.
DR   STRING; 7955.ENSDARP00000082610; -.
DR   PaxDb; A1L1R5; -.
DR   ZFIN; ZDB-GENE-070112-632; ptpdc1a.
DR   eggNOG; KOG1720; Eukaryota.
DR   InParanoid; A1L1R5; -.
DR   PhylomeDB; A1L1R5; -.
DR   PRO; PR:A1L1R5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Hydrolase; Protein phosphatase;
KW   Reference proteome.
FT   CHAIN           1..713
FT                   /note="Protein tyrosine phosphatase domain-containing
FT                   protein 1"
FT                   /id="PRO_0000312214"
FT   DOMAIN          80..251
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   ACT_SITE        188
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   713 AA;  80295 MW;  7BD6B18849697339 CRC64;
     MAAGVSLVSD LPYSTSRESN TDMETVNVRV PTAKYTKVGE TLRHVIPGHM QCSMACGGRA
     CKYENPSRWS DKEQAVKGLY SSWITDHLLA MARPSTEIVE KFNIIEQFHV CGLKTVINLQ
     RPGEHASCGS TLEPESGFTY RPELFMEAGI YFYNFGWKDY GVASLTTILD MVKVMSFAMQ
     EGKIAVHCHA GLGRTGVLIA CFLVFTSRMS ADQAILFVRA KRPNSIQTRG QLLCVREFAQ
     FLVPLRSVFS CAEPKAHEVT LSQYLTRQRH LLHGYEARHM KNMPKIIHLI CRLLLDIAEN
     RQTVEEEVLE IPDLTEEVEK TVSLQALQQL GKEMRGKGIP ISSPRSPDQP NLLGTPCDPP
     HDQPLCSDQE FDVLWRWPTV DNTYRSRLIL SKCFSYSDSA LHKLDPRVHV LQSPQNLSSK
     SGLNFSELYA SQSRLALETP DLLPSDIKSS PKHDLLTGSR SSLVQSKKIE EQVSCPPASV
     KQAPLKVAKR SMSYGFLGRT NDSSTMFSIC QVGRSTNKNS NCDVTQHFKD VPILTLQSEL
     SPETRHLFVA KALTVDLDGE ELRSKVSVWQ MELNSREGAW ERLCNERDPV VLSLLMWSWL
     EQLKEPVITK DDVETLSGNR LNPEHALNSL DKGQKQTLLC ILDCAAHLLK IPEEVENAFF
     ERLIKAFTWI SSDSENGQLI YKALKDVMVP VLRDLRTKAM EELEFTCHCS FVP