PTPC1_HUMAN
ID PTPC1_HUMAN Reviewed; 754 AA.
AC A2A3K4; Q5T3M4; Q6NXE8; Q8IWM1; Q8N1X4; Q8N9F5;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Protein tyrosine phosphatase domain-containing protein 1;
DE EC=3.1.3.-;
GN Name=PTPDC1; Synonyms=PTP9Q22;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Guo J.H., Chen L., Yu L.;
RL Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-754 (ISOFORM 1).
RC TISSUE=Amygdala, and Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-392; SER-394 AND SER-547, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC A2A3K4; P46109: CRKL; NbExp=3; IntAct=EBI-11603375, EBI-910;
CC A2A3K4; P28482: MAPK1; NbExp=3; IntAct=EBI-11603375, EBI-959949;
CC A2A3K4; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-11603375, EBI-10172526;
CC A2A3K4; Q8IYF3-3: TEX11; NbExp=3; IntAct=EBI-11603375, EBI-11523345;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2A3K4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2A3K4-2; Sequence=VSP_029736;
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class PTPDC1 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC04391.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC04421.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY171233; AAO13168.1; -; mRNA.
DR EMBL; AL360020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471089; EAW62876.1; -; Genomic_DNA.
DR EMBL; BC067120; AAH67120.1; -; mRNA.
DR EMBL; AK094631; BAC04391.1; ALT_INIT; mRNA.
DR EMBL; AK094773; BAC04421.1; ALT_INIT; mRNA.
DR CCDS; CCDS6707.1; -. [A2A3K4-1]
DR CCDS; CCDS6708.1; -. [A2A3K4-2]
DR RefSeq; NP_001240758.1; NM_001253829.1.
DR RefSeq; NP_001240759.1; NM_001253830.1.
DR RefSeq; NP_689635.3; NM_152422.4. [A2A3K4-2]
DR RefSeq; NP_818931.1; NM_177995.2. [A2A3K4-1]
DR RefSeq; XP_005251768.1; XM_005251711.4. [A2A3K4-1]
DR RefSeq; XP_011516542.1; XM_011518240.2. [A2A3K4-1]
DR RefSeq; XP_011516543.1; XM_011518241.2. [A2A3K4-1]
DR RefSeq; XP_016869769.1; XM_017014280.1. [A2A3K4-1]
DR RefSeq; XP_016869770.1; XM_017014281.1. [A2A3K4-1]
DR AlphaFoldDB; A2A3K4; -.
DR SMR; A2A3K4; -.
DR BioGRID; 126515; 69.
DR IntAct; A2A3K4; 23.
DR MINT; A2A3K4; -.
DR STRING; 9606.ENSP00000477817; -.
DR DEPOD; PTPDC1; -.
DR iPTMnet; A2A3K4; -.
DR PhosphoSitePlus; A2A3K4; -.
DR BioMuta; PTPDC1; -.
DR EPD; A2A3K4; -.
DR jPOST; A2A3K4; -.
DR MassIVE; A2A3K4; -.
DR MaxQB; A2A3K4; -.
DR PaxDb; A2A3K4; -.
DR PeptideAtlas; A2A3K4; -.
DR PRIDE; A2A3K4; -.
DR ProteomicsDB; 283; -. [A2A3K4-1]
DR ProteomicsDB; 284; -. [A2A3K4-2]
DR Antibodypedia; 13927; 23 antibodies from 8 providers.
DR DNASU; 138639; -.
DR Ensembl; ENST00000288976.3; ENSP00000288976.3; ENSG00000158079.16. [A2A3K4-2]
DR Ensembl; ENST00000375360.7; ENSP00000364509.3; ENSG00000158079.16. [A2A3K4-1]
DR Ensembl; ENST00000650567.1; ENSP00000497158.1; ENSG00000158079.16. [A2A3K4-1]
DR GeneID; 138639; -.
DR KEGG; hsa:138639; -.
DR UCSC; uc004auf.2; human. [A2A3K4-1]
DR CTD; 138639; -.
DR DisGeNET; 138639; -.
DR GeneCards; PTPDC1; -.
DR HGNC; HGNC:30184; PTPDC1.
DR HPA; ENSG00000158079; Tissue enriched (brain).
DR neXtProt; NX_A2A3K4; -.
DR OpenTargets; ENSG00000158079; -.
DR PharmGKB; PA134940207; -.
DR VEuPathDB; HostDB:ENSG00000158079; -.
DR eggNOG; KOG1720; Eukaryota.
DR GeneTree; ENSGT00390000004113; -.
DR HOGENOM; CLU_019730_0_0_1; -.
DR InParanoid; A2A3K4; -.
DR OrthoDB; 828691at2759; -.
DR PhylomeDB; A2A3K4; -.
DR TreeFam; TF313460; -.
DR PathwayCommons; A2A3K4; -.
DR SignaLink; A2A3K4; -.
DR BioGRID-ORCS; 138639; 14 hits in 1080 CRISPR screens.
DR ChiTaRS; PTPDC1; human.
DR GenomeRNAi; 138639; -.
DR Pharos; A2A3K4; Tdark.
DR PRO; PR:A2A3K4; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; A2A3K4; protein.
DR Bgee; ENSG00000158079; Expressed in tibial nerve and 159 other tissues.
DR ExpressionAtlas; A2A3K4; baseline and differential.
DR Genevisible; A2A3K4; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cilium biogenesis/degradation; Hydrolase;
KW Phosphoprotein; Protein phosphatase; Reference proteome.
FT CHAIN 1..754
FT /note="Protein tyrosine phosphatase domain-containing
FT protein 1"
FT /id="PRO_0000312212"
FT DOMAIN 82..253
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT REGION 487..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 394
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 547
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..28
FT /note="MAAGVLPQNEQPYSTLVNNSECVANMKG -> MQVQDATRRPSAVRFLSSFL
FT QGRRHSTSDPVLRLQQARRGSGLGSGSATKLLSSSSLQVMVAVSSVSHAEGNPTFPERK
FT R (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_029736"
FT VARIANT 571
FT /note="L -> Q (in dbSNP:rs16909677)"
FT /id="VAR_037455"
FT CONFLICT 27
FT /note="K -> T (in Ref. 1; AAO13168)"
FT /evidence="ECO:0000305"
FT CONFLICT 343
FT /note="V -> F (in Ref. 4; AAH67120)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="A -> D (in Ref. 1; AAO13168)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 754 AA; 84457 MW; E669F3AF34CF725F CRC64;
MAAGVLPQNE QPYSTLVNNS ECVANMKGNL ERPTPKYTKV GERLRHVIPG HMACSMACGG
RACKYENPAR WSEQEQAIKG VYSSWVTDNI LAMARPSSEL LEKYHIIDQF LSHGIKTIIN
LQRPGEHASC GNPLEQESGF TYLPEAFMEA GIYFYNFGWK DYGVASLTTI LDMVKVMTFA
LQEGKVAIHC HAGLGRTGVL IACYLVFATR MTADQAIIFV RAKRPNSIQT RGQLLCVREF
TQFLTPLRNI FSCCDPKAHA VTLPQYLIRQ RHLLHGYEAR LLKHVPKIIH LVCKLLLDLA
ENRPVMMKDV SEGPGLSAEI EKTMSEMVTM QLDKELLRHD SDVSNPPNPT AVAADFDNRG
MIFSNEQQFD PLWKRRNVEC LQPLTHLKRR LSYSDSDLKR AENLLEQGET PQTVPAQILV
GHKPRQQKLI SHCYIPQSPE PDLHKEALVR STLSFWSQSK FGGLEGLKDN GSPIFHGRII
PKEAQQSGAF SADVSGSHSP GEPVSPSFAN VHKDPNPAHQ QVSHCQCKTH GVGSPGSVRQ
NSRTPRSPLD CGSSPKAQFL VEHETQDSKD LSEAASHSAL QSELSAEARR ILAAKALANL
NESVEKEELK RKVEMWQKEL NSRDGAWERI CGERDPFILC SLMWSWVEQL KEPVITKEDV
DMLVDRRADA AEALFLLEKG QHQTILCVLH CIVNLQTIPV DVEEAFLAHA IKAFTKVNFD
SENGPTVYNT LKKIFKHTLE EKRKMTKDGP KPGL
