PTPC1_MOUSE
ID PTPC1_MOUSE Reviewed; 747 AA.
AC Q6NZK8; Q3V0Z6; Q3V3K9; Q3V3Y0; Q6NV81; Q8BKD9;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein tyrosine phosphatase domain-containing protein 1;
DE EC=3.1.3.-;
GN Name=Ptpdc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1-600 (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Eye, Hypothalamus, Pituitary, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=21289087; DOI=10.1091/mbc.e10-07-0596;
RA Lai C.K., Gupta N., Wen X., Rangell L., Chih B., Peterson A.S., Bazan J.F.,
RA Li L., Scales S.J.;
RT "Functional characterization of putative cilia genes by high-content
RT analysis.";
RL Mol. Biol. Cell 22:1104-1119(2011).
CC -!- FUNCTION: May play roles in cilia formation and/or maintenance.
CC {ECO:0000269|PubMed:21289087}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6NZK8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZK8-2; Sequence=VSP_029737, VSP_029739;
CC Name=3;
CC IsoId=Q6NZK8-3; Sequence=VSP_029738;
CC -!- DISRUPTION PHENOTYPE: Elongated cilia. {ECO:0000269|PubMed:21289087}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class PTPDC1 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE20451.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE21357.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK030415; BAE20451.1; ALT_INIT; mRNA.
DR EMBL; AK038922; BAE20543.1; -; mRNA.
DR EMBL; AK053480; BAC35397.1; -; mRNA.
DR EMBL; AK132781; BAE21357.1; ALT_INIT; mRNA.
DR EMBL; BC066081; AAH66081.1; -; mRNA.
DR EMBL; BC068267; AAH68267.1; -; mRNA.
DR CCDS; CCDS26495.1; -. [Q6NZK8-1]
DR CCDS; CCDS88450.1; -. [Q6NZK8-3]
DR RefSeq; NP_001288710.1; NM_001301781.1. [Q6NZK8-3]
DR RefSeq; NP_997115.1; NM_207232.2. [Q6NZK8-1]
DR AlphaFoldDB; Q6NZK8; -.
DR SMR; Q6NZK8; -.
DR STRING; 10090.ENSMUSP00000047374; -.
DR iPTMnet; Q6NZK8; -.
DR PhosphoSitePlus; Q6NZK8; -.
DR CPTAC; non-CPTAC-4000; -.
DR MaxQB; Q6NZK8; -.
DR PaxDb; Q6NZK8; -.
DR PeptideAtlas; Q6NZK8; -.
DR PRIDE; Q6NZK8; -.
DR ProteomicsDB; 301883; -. [Q6NZK8-1]
DR ProteomicsDB; 301884; -. [Q6NZK8-2]
DR ProteomicsDB; 301885; -. [Q6NZK8-3]
DR Antibodypedia; 13927; 23 antibodies from 8 providers.
DR DNASU; 218232; -.
DR Ensembl; ENSMUST00000035824; ENSMUSP00000047374; ENSMUSG00000038042. [Q6NZK8-1]
DR Ensembl; ENSMUST00000222028; ENSMUSP00000152771; ENSMUSG00000038042. [Q6NZK8-3]
DR GeneID; 218232; -.
DR KEGG; mmu:218232; -.
DR UCSC; uc007qii.2; mouse. [Q6NZK8-1]
DR UCSC; uc007qij.2; mouse. [Q6NZK8-3]
DR UCSC; uc007qik.2; mouse. [Q6NZK8-2]
DR CTD; 138639; -.
DR MGI; MGI:2145430; Ptpdc1.
DR VEuPathDB; HostDB:ENSMUSG00000038042; -.
DR eggNOG; KOG1720; Eukaryota.
DR GeneTree; ENSGT00390000004113; -.
DR HOGENOM; CLU_019730_0_0_1; -.
DR InParanoid; Q6NZK8; -.
DR OMA; CNERDPV; -.
DR OrthoDB; 828691at2759; -.
DR PhylomeDB; Q6NZK8; -.
DR TreeFam; TF313460; -.
DR BioGRID-ORCS; 218232; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q6NZK8; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q6NZK8; protein.
DR Bgee; ENSMUSG00000038042; Expressed in habenula and 216 other tissues.
DR ExpressionAtlas; Q6NZK8; baseline and differential.
DR Genevisible; Q6NZK8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IMP:MGI.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cilium biogenesis/degradation; Hydrolase;
KW Phosphoprotein; Protein phosphatase; Reference proteome.
FT CHAIN 1..747
FT /note="Protein tyrosine phosphatase domain-containing
FT protein 1"
FT /id="PRO_0000312213"
FT DOMAIN 82..253
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 549..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 549..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 190
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT MOD_RES 392
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2A3K4"
FT MOD_RES 394
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2A3K4"
FT MOD_RES 543
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2A3K4"
FT VAR_SEQ 1..75
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029737"
FT VAR_SEQ 27
FT /note="D -> DGEEKMLILRHLTDPVWMWSRVFCRLELAEPLRESILLVTASAMLKL
FT RFLTRLSSGLSCCIL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029738"
FT VAR_SEQ 76..85
FT /note="QAIKGVYSSW -> MFHGVWWESV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029739"
FT CONFLICT 8
FT /note="Q -> H (in Ref. 1; BAE20543)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 747 AA; 83934 MW; 7370D3AF44033D32 CRC64;
MAAGVLPQNE DPYSTLVNSS GHAAHMDENS GRPAPKYTKV GERLRHVIPG HMACSMACGG
RACKYENPAR WSEQEQAIKG VYSSWVTDNI LAMARPSSEL LEKYRIIEQF LGQGIKTIIN
LQRPGEHASC GSALEQESGF TYLPEAFMEA GIYFYNFGWK DYGVASLTAI LDMVKVMTFA
LQEGKVAVHC HAGLGRTGVL IACYLVFATR MTADQAIIFV RAKRPNSIQT RGQLLCVREF
TQFLAPLRNI FSCCDPKAHA VTLAQYLIRQ RHLLHGYEAR LLKYVPKIIH LVCKLLLDLA
ENRPVVMKSM LEGPVLSAEI EKTVSEMVTL QLDQELLRQN SDVPDPFNPT AEVAEFENQD
VILSTEQEFD PLWKRRDIEC LQPLTHLKRQ LSYSDSDLKR AKAILEQGET PWTVPAQELL
DHSLQHQKPT SHCYMPPTPE LGFNKEALVQ NTFSFWTPSK CGGLEGLKDE GSLLLCRKDI
PKEVQRSRTF SVGVSCSHNP GEPVPPNFTS IHKDPEQVTH CRCEAPGGWV PGPVHEMVRS
PCSPLNCGSS PKAQFPHGQE TQDSTDLSEA VPHAGLQPEL SAEARRILAA KALANLNEFV
EKEEVKRKVE MWQKELNSRE EAWERICGER DPFILCSLMW SWVEQLKEPV ITKEDVDMLV
DRQADAAEAL FLLEKGQYQT ILCVLHCIVS LQTLPMEVEE ACLLHAIKAF TKVNFDSENG
PIVYDTLKKI FKHTLEEKRK MAKDSLS
