ID   PTPH1_MDBVW             Reviewed;         336 AA.
AC   Q5I147;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Tyrosine phosphatase-like protein H1;
DE            Short=PTP-H1;
GN   Name=H1;
OS   Microplitis demolitor bracovirus (isolate Webb) (MdBV).
OC   Viruses; Polydnaviridae; Bracovirus.
OX   NCBI_TaxID=654919;
OH   NCBI_TaxID=69319; Microplitis demolitor.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16380146; DOI=10.1016/j.virol.2005.11.010;
RA   Webb B.A., Strand M.R., Dickey S.E., Beck M.H., Hilgarth R.S., Barney W.E.,
RA   Kadash K., Kroemer J.A., Lindstrom K.G., Rattanadechakul W., Shelby K.S.,
RA   Thoetkiattikul H., Turnbull M.W., Witherell R.A.;
RT   "Polydnavirus genomes reflect their dual roles as mutualists and
RT   pathogens.";
RL   Virology 347:160-174(2006).
RN   [2]
RP   ABSENCE OF CATALYTIC ACTIVITY.
RX   PubMed=17121799; DOI=10.1128/jvi.02189-06;
RA   Pruijssers A.J., Strand M.R.;
RT   "PTP-H2 and PTP-H3 from Microplitis demolitor Bracovirus localize to focal
RT   adhesions and are antiphagocytic in insect immune cells.";
RL   J. Virol. 81:1209-1219(2007).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: PTP-H1 does not appear to be a functional PTP. {ECO:0000305}.
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DR   EMBL; AY875685; AAW51785.1; -; Genomic_DNA.
DR   RefSeq; YP_239381.1; NC_007035.1.
DR   SMR; Q5I147; -.
DR   GeneID; 5075816; -.
DR   KEGG; vg:5075816; -.
DR   Proteomes; UP000008168; Genome.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..336
FT                   /note="Tyrosine phosphatase-like protein H1"
FT                   /id="PRO_0000405371"
FT   DOMAIN          27..295
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   336 AA;  39530 MW;  186E38E2343C708A CRC64;
     MGRHSFKTVS IDEFLELTLR PDLLNLIKKE HHKLMKVKLP GTIANFSRPE NSSKNRSTLF
     PCWDESRVIL KSPSKGIPYD NDITSTYIHA NFVDGFKDKN KFICSQSPME NTCEDFWRMI
     LQENCHIIVS LTKVDNAVYC YEYWANEKYR EKVFGKYVIK TLEIIEEEVF TRSRLLLTDT
     NNDISQEIHH FWYTNFPLHY GWPIMSPELL NLIFHVDQKR EELMNTTGSG PIVIHCSKIV
     SWTGIFCTIY NALSQVREEK TVSLPQTVLN IRKKRHSSIM NWVEYEICYR VLCEAILNLK
     TFMYCNLEIF SAFQDKVAAI NFYFGKSHNK HSFNNK