PTR15_ARATH
ID PTR15_ARATH Reviewed; 601 AA.
AC Q56XQ6; Q9C808;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Protein NRT1/ PTR FAMILY 4.4;
DE Short=AtNPF4.4;
DE AltName: Full=Nitrate transporter 1.13;
GN Name=NPF4.4; Synonyms=NRT1.13; OrderedLocusNames=At1g33440;
GN ORFNames=F10C21.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT "Nitrate transporters and peptide transporters.";
RL FEBS Lett. 581:2290-2300(2007).
RN [5]
RP GENE FAMILY.
RX PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA Gong J.M.;
RT "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT from the xylem sap and mediates cadmium tolerance.";
RL Plant Cell 22:1633-1646(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24055139; DOI=10.1016/j.tplants.2013.08.008;
RA Leran S., Varala K., Boyer J.C., Chiurazzi M., Crawford N.,
RA Daniel-Vedele F., David L., Dickstein R., Fernandez E., Forde B.,
RA Gassmann W., Geiger D., Gojon A., Gong J.M., Halkier B.A., Harris J.M.,
RA Hedrich R., Limami A.M., Rentsch D., Seo M., Tsay Y.F., Zhang M.,
RA Coruzzi G., Lacombe B.;
RT "A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family
RT members in plants.";
RL Trends Plant Sci. 19:5-9(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in shoots, roots and stems.
CC {ECO:0000269|PubMed:17481610}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51210.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC051630; AAG51210.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31595.1; -; Genomic_DNA.
DR EMBL; AK221617; BAD95216.1; -; mRNA.
DR PIR; B86458; B86458.
DR RefSeq; NP_174610.2; NM_103069.4.
DR AlphaFoldDB; Q56XQ6; -.
DR SMR; Q56XQ6; -.
DR STRING; 3702.AT1G33440.1; -.
DR TCDB; 2.A.17.3.24; the proton-dependent oligopeptide transporter (pot/ptr) family.
DR iPTMnet; Q56XQ6; -.
DR PaxDb; Q56XQ6; -.
DR PRIDE; Q56XQ6; -.
DR ProteomicsDB; 226424; -.
DR EnsemblPlants; AT1G33440.1; AT1G33440.1; AT1G33440.
DR GeneID; 840237; -.
DR Gramene; AT1G33440.1; AT1G33440.1; AT1G33440.
DR KEGG; ath:AT1G33440; -.
DR Araport; AT1G33440; -.
DR TAIR; locus:2006907; AT1G33440.
DR eggNOG; KOG1237; Eukaryota.
DR HOGENOM; CLU_009313_4_0_1; -.
DR InParanoid; Q56XQ6; -.
DR OMA; FNCAYFA; -.
DR OrthoDB; 365203at2759; -.
DR PhylomeDB; Q56XQ6; -.
DR PRO; PR:Q56XQ6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q56XQ6; baseline and differential.
DR Genevisible; Q56XQ6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR000109; POT_fam.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..601
FT /note="Protein NRT1/ PTR FAMILY 4.4"
FT /id="PRO_0000399949"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 453..473
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 544..564
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 112
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q05085"
SQ SEQUENCE 601 AA; 66705 MW; 970E0562F32D643D CRC64;
MDVHDLSEEA KRGVIHTSEE SLDDLCVDFR GRPCRPSKHG GTRAALFVLG FQAFEMMAIA
AVGNNLITYV FNEMHFPLSK SANLVTNFIG TVFLLSLLGG FLSDSYLGSF RTMLVFGVIE
ISGFILLSVQ AHLPELRPPE CNMKSTTIHC VEANGYKAAT LYTALCLVAL GSGCLKPNII
SHGANQFQRK DLRKLSSFFN AAYFAFSMGQ LIALTLLVWV QTHSGMDVGF GVSAAVMAAG
MISLVAGTSF YRNKPPSGSI FTPIAQVFVA AITKRKQICP SNPNMVHQPS TDLVRVKPLL
HSNKFRFLDK ACIKTQGKAM ESPWRLCTIE QVHQVKILLS VIPIFACTII FNTILAQLQT
FSVQQGSSMN THITKTFQIP PASLQAIPYI ILIFFVPLYE TFFVPLARKL TGNDSGISPL
QRIGTGLFLA TFSMVAAALV EKKRRESFLE QNVMLSIFWI APQFLIFGLS EMFTAVGLVE
FFYKQSSQSM QSFLTAMTYC SYSFGFYLSS VLVSTVNRVT SSNGSGTKEG WLGDNDLNKD
RLDHFYWLLA SLSFINFFNY LFWSRWYSCD PSATHHSAEV NSLEALENGE IKDSTTEKPR
I
