PTR1_METJA
ID PTR1_METJA Reviewed; 148 AA.
AC Q57615;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=HTH-type transcriptional regulator Ptr1;
GN Name=ptr1; OrderedLocusNames=MJ0151;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP CHARACTERIZATION.
RX PubMed=11226165; DOI=10.1093/emboj/20.1.146;
RA Ouhammouch M., Geiduschek E.P.;
RT "A thermostable platform for transcriptional regulation: the DNA-binding
RT properties of two Lrp homologs from the hyperthermophilic archaeon
RT Methanococcus jannaschii.";
RL EMBO J. 20:146-156(2001).
CC -!- FUNCTION: Participates in positive as well as negative regulation of
CC transcription. Binds to its own promoter.
CC -!- SUBUNIT: Homodimer.
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DR EMBL; L77117; AAB98133.1; -; Genomic_DNA.
DR PIR; H64318; H64318.
DR RefSeq; WP_010869646.1; NC_000909.1.
DR AlphaFoldDB; Q57615; -.
DR SMR; Q57615; -.
DR STRING; 243232.MJ_0151; -.
DR EnsemblBacteria; AAB98133; AAB98133; MJ_0151.
DR GeneID; 1450995; -.
DR KEGG; mja:MJ_0151; -.
DR eggNOG; arCOG01580; Archaea.
DR HOGENOM; CLU_091233_5_2_2; -.
DR InParanoid; Q57615; -.
DR OMA; NIFCKIR; -.
DR OrthoDB; 97695at2157; -.
DR PhylomeDB; Q57615; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01037; AsnC_trans_reg; 1.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54909; SSF54909; 1.
DR PROSITE; PS00519; HTH_ASNC_1; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..148
FT /note="HTH-type transcriptional regulator Ptr1"
FT /id="PRO_0000111752"
FT DOMAIN 2..63
FT /note="HTH asnC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT DNA_BIND 21..40
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ SEQUENCE 148 AA; 16633 MW; B3AAAC4B34A39982 CRC64;
MLDRIDLKIL RILNGNARKS FREIGRELGI SEGTVRNRVK RLTEKGIITG FHASINPKNL
GFEVVAILGL YIKPSKVEET LNKLKELDEI VELYQTTGEY DAVCIAILKD IESLGKFLAE
KIYPLVNVNG CKVTLVLRTF KDGSKMPI
