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PTR22_ARATH
ID   PTR22_ARATH             Reviewed;         557 AA.
AC   Q8VZE2; Q9C7H5;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Protein NRT1/ PTR FAMILY 5.14;
DE            Short=AtNPF5.14;
DE   AltName: Full=Nitrate transporter 1.15;
GN   Name=NPF5.14; Synonyms=NRT1.15; OrderedLocusNames=At1g72120;
GN   ORFNames=F28P5.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   TISSUE SPECIFICITY, AND GENE FAMILY.
RX   PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA   Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT   "Nitrate transporters and peptide transporters.";
RL   FEBS Lett. 581:2290-2300(2007).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA   Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA   Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA   Gong J.M.;
RT   "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT   from the xylem sap and mediates cadmium tolerance.";
RL   Plant Cell 22:1633-1646(2010).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24055139; DOI=10.1016/j.tplants.2013.08.008;
RA   Leran S., Varala K., Boyer J.C., Chiurazzi M., Crawford N.,
RA   Daniel-Vedele F., David L., Dickstein R., Fernandez E., Forde B.,
RA   Gassmann W., Geiger D., Gojon A., Gong J.M., Halkier B.A., Harris J.M.,
RA   Hedrich R., Limami A.M., Rentsch D., Seo M., Tsay Y.F., Zhang M.,
RA   Coruzzi G., Lacombe B.;
RT   "A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family
RT   members in plants.";
RL   Trends Plant Sci. 19:5-9(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots. {ECO:0000269|PubMed:17481610}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51133.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g72120 has been split into 2 genes: At1g72120 and At1g72115.; Evidence={ECO:0000305};
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DR   EMBL; AC069273; AAG51133.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE35276.1; -; Genomic_DNA.
DR   EMBL; AY065020; AAL57662.1; -; mRNA.
DR   EMBL; BT001020; AAN46774.1; -; mRNA.
DR   RefSeq; NP_177357.2; NM_105870.4.
DR   AlphaFoldDB; Q8VZE2; -.
DR   SMR; Q8VZE2; -.
DR   STRING; 3702.AT1G72120.1; -.
DR   iPTMnet; Q8VZE2; -.
DR   PaxDb; Q8VZE2; -.
DR   PRIDE; Q8VZE2; -.
DR   ProteomicsDB; 224839; -.
DR   EnsemblPlants; AT1G72120.1; AT1G72120.1; AT1G72120.
DR   GeneID; 843543; -.
DR   Gramene; AT1G72120.1; AT1G72120.1; AT1G72120.
DR   KEGG; ath:AT1G72120; -.
DR   Araport; AT1G72120; -.
DR   TAIR; locus:2030326; AT1G72120.
DR   eggNOG; KOG1237; Eukaryota.
DR   HOGENOM; CLU_009313_4_1_1; -.
DR   OMA; MKHISTH; -.
DR   OrthoDB; 365203at2759; -.
DR   PRO; PR:Q8VZE2; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q8VZE2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd17417; MFS_NPF5; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR044739; NRT1/PTR.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..557
FT                   /note="Protein NRT1/ PTR FAMILY 5.14"
FT                   /id="PRO_0000399956"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        443..463
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        479..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         103
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05085"
FT   CONFLICT        24
FT                   /note="A -> D (in Ref. 3; AAL57662/AAN46774)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   557 AA;  61924 MW;  A89478741BC7EA82 CRC64;
     MTTTSEISLQ EEYVTDAVDH RGLAARRSNT GRWRAALFII GVEVAERFAY YGIGSNLISY
     LTGPLGESTA VAAANVNAWS GIATLLPVLG AFVADAFLGR YRTIIISSLI YVLGLAFLTL
     SAFLIPNTTE VTSSTSSFLN VLFFFSLYLV AIGQSGHKPC VQAFGADQFD EKDSQEKSDR
     SSFFNWWYLS LSAGICFAIL VVVYIQEEFS WAFGFGIPCV FMVISLVLFV SGRRIYRYSK
     RRHEEEINPF TRIGRVFFVA LKNQRLSSSD LCKVELEANT SPEKQSFFNK ALLVPNDSSQ
     GENASKSSDV EDATALIRLI PVWFTTLAYA IPYAQYMTFF TKQGVTMDRT ILPGVKIPPA
     SLQVFIGISI VLFVPIYDRV FVPIARLITK EPCGITTLKR IGTGIVLSTI TMVIAALVEF
     KRLETAKEHG LIDQPEATLP MSIWWLIPQY LLLGLADVYT LVGMQEFFYS QVPTELRSIG
     LALYLSALGV GSLLSSLLIS LIDLATGGDA GNSWFNSNLN RAHLDYFYWL LAIVSAVGFF
     TFLFISKSYI YRRVDRV
 
 
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