PTR23_ARATH
ID PTR23_ARATH Reviewed; 561 AA.
AC Q0WSZ6; Q9C7H5;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Protein NRT1/ PTR FAMILY 5.13;
DE Short=AtNPF5.13;
DE AltName: Full=Nitrate transporter 1.16;
GN Name=NPF5.13; Synonyms=NRT1.16; OrderedLocusNames=At1g72125;
GN ORFNames=F28P5.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-561.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT "Nitrate transporters and peptide transporters.";
RL FEBS Lett. 581:2290-2300(2007).
RN [5]
RP GENE FAMILY.
RX PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA Gong J.M.;
RT "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT from the xylem sap and mediates cadmium tolerance.";
RL Plant Cell 22:1633-1646(2010).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24055139; DOI=10.1016/j.tplants.2013.08.008;
RA Leran S., Varala K., Boyer J.C., Chiurazzi M., Crawford N.,
RA Daniel-Vedele F., David L., Dickstein R., Fernandez E., Forde B.,
RA Gassmann W., Geiger D., Gojon A., Gong J.M., Halkier B.A., Harris J.M.,
RA Hedrich R., Limami A.M., Rentsch D., Seo M., Tsay Y.F., Zhang M.,
RA Coruzzi G., Lacombe B.;
RT "A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family
RT members in plants.";
RL Trends Plant Sci. 19:5-9(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, flowers and siliques. Detected
CC in stems and leaves. {ECO:0000269|PubMed:17481610}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51133.1; Type=Erroneous gene model prediction; Note=The predicted gene At1g72120 has been split into 2 genes: At1g72120 and At1g72115.; Evidence={ECO:0000305};
CC Sequence=BAE99752.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. Its 3'- and 5'-sequences are derived from the gene At4g26240.; Evidence={ECO:0000305};
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DR EMBL; AC069273; AAG51133.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35277.1; -; Genomic_DNA.
DR EMBL; AK227770; BAE99752.1; ALT_SEQ; mRNA.
DR PIR; E96744; E96744.
DR RefSeq; NP_001117585.1; NM_001124113.2.
DR AlphaFoldDB; Q0WSZ6; -.
DR SMR; Q0WSZ6; -.
DR STRING; 3702.AT1G72125.1; -.
DR iPTMnet; Q0WSZ6; -.
DR PaxDb; Q0WSZ6; -.
DR PRIDE; Q0WSZ6; -.
DR ProteomicsDB; 226447; -.
DR EnsemblPlants; AT1G72125.1; AT1G72125.1; AT1G72125.
DR GeneID; 6241212; -.
DR Gramene; AT1G72125.1; AT1G72125.1; AT1G72125.
DR KEGG; ath:AT1G72125; -.
DR Araport; AT1G72125; -.
DR TAIR; locus:4515102750; AT1G72125.
DR eggNOG; KOG1237; Eukaryota.
DR HOGENOM; CLU_009313_4_1_1; -.
DR InParanoid; Q0WSZ6; -.
DR OMA; PQYLMLG; -.
DR OrthoDB; 365203at2759; -.
DR PhylomeDB; Q0WSZ6; -.
DR PRO; PR:Q0WSZ6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q0WSZ6; baseline and differential.
DR Genevisible; Q0WSZ6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17417; MFS_NPF5; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044739; NRT1/PTR.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS01022; PTR2_1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..561
FT /note="Protein NRT1/ PTR FAMILY 5.13"
FT /id="PRO_0000399957"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 530..550
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 103
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q05085"
SQ SEQUENCE 561 AA; 62262 MW; 0891EEEDF7871C57 CRC64;
MTTTSKTSLQ EEYVIDAVDH RGFSARRSIT GRWRAAWFII GVEVAERFAN YGIGSNLISY
LTGPLGQSTA VAAANVNAWS GISTILPLLG AFVADAFLGR YITIIIASFI YVLGLAFLTL
SAFLIPNNTE VTSSPSSFLN ALFFFSLYLV AIGQSGHKPC VQAFGADQFD EKNPQENSDR
SSFFNWWYLS MCAGIGLAIL VVVYIQENVS WALGFGIPCV FMVISLVLFV LGRKSYRFSK
TRQEEETNPF TRIGRVFFVA FKNQRLNSSD LCKVELIEAN RSQESPEELS FLNKALLVPN
DSDEGEVACK SRDVEDATAL VRLIPVWLTT LAYAIPFAQY MTFFTKQGVT MERTIFPGVE
IPPASLQVLI SISIVLFVPI YDRVLVPIGR SITKDPCGIT TLKRIGTGMV LATLTMVVAA
LVESKRLETA KEYGLIDQPK TTLPMSIWWL FPQYMLLGLA DVHTLVGMQE FFYSQVPTEL
RSLGLAIYLS AMGVGSLLSS LLIYLIDLAT GGDAGNSWFN SNLNRAHLDY FYWLLAVVSA
VGFFTFLFIS KSYIYRRVDV V
