PTR28_ARATH
ID PTR28_ARATH Reviewed; 575 AA.
AC P0CI03;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Protein NRT1/ PTR FAMILY 5.6;
DE Short=AtNPF5.6;
GN Name=NPF5.6; OrderedLocusNames=At2g37900; ORFNames=T8P21.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT "Nitrate transporters and peptide transporters.";
RL FEBS Lett. 581:2290-2300(2007).
RN [4]
RP GENE FAMILY.
RX PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA Gong J.M.;
RT "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT from the xylem sap and mediates cadmium tolerance.";
RL Plant Cell 22:1633-1646(2010).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24055139; DOI=10.1016/j.tplants.2013.08.008;
RA Leran S., Varala K., Boyer J.C., Chiurazzi M., Crawford N.,
RA Daniel-Vedele F., David L., Dickstein R., Fernandez E., Forde B.,
RA Gassmann W., Geiger D., Gojon A., Gong J.M., Halkier B.A., Harris J.M.,
RA Hedrich R., Limami A.M., Rentsch D., Seo M., Tsay Y.F., Zhang M.,
RA Coruzzi G., Lacombe B.;
RT "A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family
RT members in plants.";
RL Trends Plant Sci. 19:5-9(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in stems, shoots, leaves, flowers and
CC siliques. {ECO:0000269|PubMed:17481610}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC {ECO:0000305}.
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DR EMBL; CP002685; AEC09463.1; -; Genomic_DNA.
DR PIR; E84798; E84798.
DR RefSeq; NP_181326.1; NM_129346.2.
DR AlphaFoldDB; P0CI03; -.
DR SMR; P0CI03; -.
DR PaxDb; P0CI03; -.
DR PRIDE; P0CI03; -.
DR ProteomicsDB; 226244; -.
DR EnsemblPlants; AT2G37900.1; AT2G37900.1; AT2G37900.
DR GeneID; 818366; -.
DR Gramene; AT2G37900.1; AT2G37900.1; AT2G37900.
DR KEGG; ath:AT2G37900; -.
DR Araport; AT2G37900; -.
DR TAIR; locus:2065568; AT2G37900.
DR eggNOG; KOG1237; Eukaryota.
DR HOGENOM; CLU_009313_4_1_1; -.
DR InParanoid; P0CI03; -.
DR OMA; TIMDRHI; -.
DR OrthoDB; 365203at2759; -.
DR PRO; PR:P0CI03; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; P0CI03; baseline and differential.
DR Genevisible; P0CI03; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17417; MFS_NPF5; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR044739; NRT1/PTR.
DR InterPro; IPR000109; POT_fam.
DR InterPro; IPR018456; PTR2_symporter_CS.
DR PANTHER; PTHR11654; PTHR11654; 1.
DR Pfam; PF00854; PTR2; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS01022; PTR2_1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..575
FT /note="Protein NRT1/ PTR FAMILY 5.6"
FT /id="PRO_0000399962"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 541..561
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 112
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q05085"
SQ SEQUENCE 575 AA; 64306 MW; 96C59544E10B30B8 CRC64;
MEHKNIGAEV LQDTYDDQQK WVLDSSLDSR GRVPLRARTG AWRAALFIIA IEFSERLSYF
GLATNLVVYL TTILNQDLKM AIRNVNYWSG VTTLMPLLGG FIADAYLGRY ATVLVATTIY
LMGLVLLTMS WFIPGLKPCH QEVCVEPRKA HEVAFFIAIY LISIGTGGHK PSLESFGADQ
FDDDHVEERK MKMSFFNWWN VSLCAGILTA VTAVAYIEDR VGWGVAGIIL TVVMAISLII
FFIGKPFYRY RTPSGSPLTP ILQVFVAAIA KRNLPYPSDP SLLHEVSKTE FTSGRLLCHT
EHLKFLDKAA IIEDKNPLAL EKQSPWRLLT LTKVEETKLI INVIPIWFST LAFGICATQA
STFFIKQAIT MDRHIGGFTV PPASMFTLTA LTLIISLTVY EKLLVPLLRS ITRNQRGINI
LQRIGTGMIF SLITMIIAAL VEKQRLDRTN NNKPMSVIWL APQFMVIGFA DAFTLVGLQE
YFYHQVPDSM RSLGIAFYLS VIGAASFLNN LLITAVDTLA ENFSGKSWFG KDLNSSRLDR
FYWFLAGVIA ANICVFVIVA KRCPYKSVQP SQGLS
