ID   PTR2_METJA              Reviewed;         140 AA.
AC   Q58133;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   18-OCT-2001, sequence version 2.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=HTH-type transcriptional regulator Ptr2;
GN   Name=ptr2; OrderedLocusNames=MJ0723;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=11226165; DOI=10.1093/emboj/20.1.146;
RA   Ouhammouch M., Geiduschek E.P.;
RT   "A thermostable platform for transcriptional regulation: the DNA-binding
RT   properties of two Lrp homologs from the hyperthermophilic archaeon
RT   Methanococcus jannaschii.";
RL   EMBO J. 20:146-156(2001).
CC   -!- FUNCTION: Participates in positive as well as negative regulation of
CC       transcription. Binds to its own promoter.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB98719.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L77117; AAB98719.1; ALT_INIT; Genomic_DNA.
DR   PIR; C64390; C64390.
DR   RefSeq; WP_064496594.1; NC_000909.1.
DR   AlphaFoldDB; Q58133; -.
DR   SMR; Q58133; -.
DR   STRING; 243232.MJ_0723; -.
DR   EnsemblBacteria; AAB98719; AAB98719; MJ_0723.
DR   GeneID; 1451600; -.
DR   KEGG; mja:MJ_0723; -.
DR   eggNOG; arCOG01580; Archaea.
DR   HOGENOM; CLU_091233_5_4_2; -.
DR   InParanoid; Q58133; -.
DR   OMA; EDCWFIA; -.
DR   OrthoDB; 97695at2157; -.
DR   PhylomeDB; Q58133; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   CDD; cd00090; HTH_ARSR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011991; ArsR-like_HTH.
DR   InterPro; IPR000485; AsnC-type_HTH_dom.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR   InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR   InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01037; AsnC_trans_reg; 1.
DR   Pfam; PF13404; HTH_AsnC-type; 1.
DR   PRINTS; PR00033; HTHASNC.
DR   SMART; SM00344; HTH_ASNC; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF54909; SSF54909; 1.
DR   PROSITE; PS00519; HTH_ASNC_1; 1.
DR   PROSITE; PS50956; HTH_ASNC_2; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..140
FT                   /note="HTH-type transcriptional regulator Ptr2"
FT                   /id="PRO_0000111753"
FT   DOMAIN          1..62
FT                   /note="HTH asnC-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
SQ   SEQUENCE   140 AA;  15903 MW;  B2135182FF834EC9 CRC64;
     MDEKDLKIIE ILMRDGRKSY TDIARELGTS ESSIRKRVKK LEEEGVIKGY TAIIDPSKIG
     YNVVALTGFD TEPDKFLNVA KELCKFPEVK KVFTSTGDHM IMTEIWAKDG KEFSDLIFNK
     IGKIEGIKKI CPAIILEQMK