PTR36_ARATH
ID PTR36_ARATH Reviewed; 484 AA.
AC Q3EAQ5; Q9LZG8;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Probable peptide/nitrate transporter At3g43790;
DE AltName: Full=Protein ZINC INDUCED FACILITATOR-LIKE 2;
GN Name=ZIFL2; OrderedLocusNames=At3g43790; ORFNames=T28A8.80;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=17277087; DOI=10.1104/pp.106.092015;
RA Haydon M.J., Cobbett C.S.;
RT "A novel major facilitator superfamily protein at the tonoplast influences
RT zinc tolerance and accumulation in Arabidopsis.";
RL Plant Physiol. 143:1705-1719(2007).
RN [5]
RP GENE FAMILY.
RX PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA Gong J.M.;
RT "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT from the xylem sap and mediates cadmium tolerance.";
RL Plant Cell 22:1633-1646(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3EAQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3EAQ5-2; Sequence=VSP_039950;
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:17277087}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB83151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL162691; CAB83151.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77827.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77828.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77829.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM64408.1; -; Genomic_DNA.
DR EMBL; BT030378; ABO38791.1; -; mRNA.
DR PIR; T47415; T47415.
DR RefSeq; NP_001326438.1; NM_001339105.1. [Q3EAQ5-2]
DR RefSeq; NP_189965.2; NM_114247.4. [Q3EAQ5-2]
DR RefSeq; NP_974382.1; NM_202653.1. [Q3EAQ5-1]
DR RefSeq; NP_974383.1; NM_202654.1. [Q3EAQ5-1]
DR AlphaFoldDB; Q3EAQ5; -.
DR SMR; Q3EAQ5; -.
DR STRING; 3702.AT3G43790.3; -.
DR TCDB; 2.A.1.2.96; the major facilitator superfamily (mfs).
DR PaxDb; Q3EAQ5; -.
DR PRIDE; Q3EAQ5; -.
DR ProteomicsDB; 226422; -. [Q3EAQ5-1]
DR EnsemblPlants; AT3G43790.1; AT3G43790.1; AT3G43790. [Q3EAQ5-2]
DR EnsemblPlants; AT3G43790.2; AT3G43790.2; AT3G43790. [Q3EAQ5-1]
DR EnsemblPlants; AT3G43790.3; AT3G43790.3; AT3G43790. [Q3EAQ5-1]
DR EnsemblPlants; AT3G43790.4; AT3G43790.4; AT3G43790. [Q3EAQ5-2]
DR GeneID; 823490; -.
DR Gramene; AT3G43790.1; AT3G43790.1; AT3G43790. [Q3EAQ5-2]
DR Gramene; AT3G43790.2; AT3G43790.2; AT3G43790. [Q3EAQ5-1]
DR Gramene; AT3G43790.3; AT3G43790.3; AT3G43790. [Q3EAQ5-1]
DR Gramene; AT3G43790.4; AT3G43790.4; AT3G43790. [Q3EAQ5-2]
DR KEGG; ath:AT3G43790; -.
DR Araport; AT3G43790; -.
DR TAIR; locus:2101109; AT3G43790.
DR eggNOG; KOG2615; Eukaryota.
DR InParanoid; Q3EAQ5; -.
DR OMA; CWGIGMI; -.
DR OrthoDB; 1090653at2759; -.
DR PhylomeDB; Q3EAQ5; -.
DR PRO; PR:Q3EAQ5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q3EAQ5; baseline and differential.
DR Genevisible; Q3EAQ5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..484
FT /note="Probable peptide/nitrate transporter At3g43790"
FT /id="PRO_0000399970"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 460..480
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 451..456
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_039950"
SQ SEQUENCE 484 AA; 53275 MW; 6C9F72151798543D CRC64;
MADDESRTIL LEKNEDCPGC IIDRTKQQQR GVPYLHLSFI WLVSLCTALP ISSLFPYIYF
MIRDFHIAKQ EEDIGFYAGF VGSSFMIGRA LTSIFWGKLA DRYGRKPIIL IGTFSVIIFN
TLFGLSTSFW LAISVRFLLG CFNCLLGVIR AYASEVVSEE YNALSLSVVS TSRGIGLILG
PAIGGYLAQP AEKYPNIFSQ SSVFGRFPYF LPSLVISVYA TAVLIACWWL PETLHTRCRI
AQGRLNPTEL NDDESRGGGL DEQKIINKPS LLRNRPLMAI IIVYCVFSLQ EIAYNEIFSL
WAVSDRSYGG LSFSSQDVGE VLAISGLGLL VFQLLVYPPL EKSVGLLAVI RLSAVLLIPL
LSCYPYIALL SGVTLHLVIN CASIIKNALS ISLVTGLFIM LNKAVPQNQR GAANGISMTA
MSVFKSFGPA GGGVLFSWAQ KRQDATFLPG QIFAPCDEMV FLVLNLVQLV GLILTFIPYI
SQIQ
