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PTR49_ARATH
ID   PTR49_ARATH             Reviewed;         624 AA.
AC   Q9LYR6;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Protein NRT1/ PTR FAMILY 6.1;
DE            Short=AtNPF6.1;
GN   Name=NPF6.1; OrderedLocusNames=At5g13400; ORFNames=T22N19.50;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   TISSUE SPECIFICITY, AND GENE FAMILY.
RX   PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA   Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT   "Nitrate transporters and peptide transporters.";
RL   FEBS Lett. 581:2290-2300(2007).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA   Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA   Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA   Gong J.M.;
RT   "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT   from the xylem sap and mediates cadmium tolerance.";
RL   Plant Cell 22:1633-1646(2010).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24055139; DOI=10.1016/j.tplants.2013.08.008;
RA   Leran S., Varala K., Boyer J.C., Chiurazzi M., Crawford N.,
RA   Daniel-Vedele F., David L., Dickstein R., Fernandez E., Forde B.,
RA   Gassmann W., Geiger D., Gojon A., Gong J.M., Halkier B.A., Harris J.M.,
RA   Hedrich R., Limami A.M., Rentsch D., Seo M., Tsay Y.F., Zhang M.,
RA   Coruzzi G., Lacombe B.;
RT   "A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family
RT   members in plants.";
RL   Trends Plant Sci. 19:5-9(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in flower and siliques.
CC       {ECO:0000269|PubMed:17481610}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC       {ECO:0000305}.
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DR   EMBL; AL163572; CAB87147.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED91890.1; -; Genomic_DNA.
DR   EMBL; AY072338; AAL61945.1; -; mRNA.
DR   EMBL; AY128754; AAM91154.1; -; mRNA.
DR   PIR; T48587; T48587.
DR   RefSeq; NP_196844.1; NM_121343.5.
DR   AlphaFoldDB; Q9LYR6; -.
DR   SMR; Q9LYR6; -.
DR   BioGRID; 16459; 31.
DR   IntAct; Q9LYR6; 31.
DR   STRING; 3702.AT5G13400.1; -.
DR   iPTMnet; Q9LYR6; -.
DR   PaxDb; Q9LYR6; -.
DR   PRIDE; Q9LYR6; -.
DR   ProteomicsDB; 226445; -.
DR   EnsemblPlants; AT5G13400.1; AT5G13400.1; AT5G13400.
DR   GeneID; 831181; -.
DR   Gramene; AT5G13400.1; AT5G13400.1; AT5G13400.
DR   KEGG; ath:AT5G13400; -.
DR   Araport; AT5G13400; -.
DR   TAIR; locus:2181655; AT5G13400.
DR   eggNOG; KOG1237; Eukaryota.
DR   HOGENOM; CLU_009313_4_0_1; -.
DR   InParanoid; Q9LYR6; -.
DR   OMA; YITAFGA; -.
DR   OrthoDB; 365203at2759; -.
DR   PhylomeDB; Q9LYR6; -.
DR   PRO; PR:Q9LYR6; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LYR6; baseline and differential.
DR   Genevisible; Q9LYR6; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006857; P:oligopeptide transport; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   InterPro; IPR018456; PTR2_symporter_CS.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS01022; PTR2_1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..624
FT                   /note="Protein NRT1/ PTR FAMILY 6.1"
FT                   /id="PRO_0000399983"
FT   TRANSMEM        83..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        459..479
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        504..524
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        537..557
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        585..605
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         138
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05085"
SQ   SEQUENCE   624 AA;  69075 MW;  3D74D80A9C3C635A CRC64;
     MVASEIKSPV SVPETPGSSS VHHRKQLSVF FIESDNRRLA LGRGYTGGTT PVNIHGKPIA
     NLSKTGGWIA AFFIFGNEMA ERMAYFGLSV NMVAFMFYVM HRPFESSSNA VNNFLGISQA
     SSVLGGFLAD AYLGRYWTIA IFTTMYLVGL IGITLGASLK MFVPDQSNCG QLSLLLGNCE
     EAKSWQMLYL YTVLYITGFG AAGIRPCVSS FGADQFDEKS KDYKTHLDRF FNFFYLSVTL
     GAIIAFTLVV YVQMELGWGM AFGTLAVAMG ISNALFFAGT PLYRHRLPGG SPLTRVAQVL
     VAAFRKRNAA FTSSEFIGLY EVPGLKSAIN GSRKIPHSND FIWLDKAALE LKEDGLEPSP
     WKLCTVTQVE EVKILIRLIP IPTCTIMLSL VLTEYLTLSV QQAYTLNTHI QHLKLPVTCM
     PVFPGLSIFL ILSLYYSVFV PITRRITGNP HGASQLQRVG IGLAVSIISV AWAGLFENYR
     RHYAIQNGFE FNFLTQMPDL TAYWLLIQYC LIGIAEVFCI VGLLEFLYEE APDAMKSIGS
     AYAALAGGLG CFAATILNNI VKAATRDSDG KSWLSQNINT GRFDCLYWLL TLLSFLNFCV
     FLWSAHRYKY RAIESEEDKS SAVL
 
 
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