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PTR50_ARATH
ID   PTR50_ARATH             Reviewed;         552 AA.
AC   Q9LFR1; Q0WVI4;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Protein NRT1/ PTR FAMILY 5.8;
DE            Short=AtNPF5.8;
GN   Name=NPF5.8; OrderedLocusNames=At5g14940; ORFNames=F2G14.60;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-530.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   INDUCTION BY NEMATODES.
RX   PubMed=16478044; DOI=10.1094/mpmi-18-1247;
RA   Hammes U.Z., Schachtman D.P., Berg R.H., Nielsen E., Koch W.,
RA   McIntyre L.M., Taylor C.G.;
RT   "Nematode-induced changes of transporter gene expression in Arabidopsis
RT   roots.";
RL   Mol. Plant Microbe Interact. 18:1247-1257(2005).
RN   [5]
RP   TISSUE SPECIFICITY, AND GENE FAMILY.
RX   PubMed=17481610; DOI=10.1016/j.febslet.2007.04.047;
RA   Tsay Y.F., Chiu C.C., Tsai C.B., Ho C.H., Hsu P.K.;
RT   "Nitrate transporters and peptide transporters.";
RL   FEBS Lett. 581:2290-2300(2007).
RN   [6]
RP   GENE FAMILY.
RX   PubMed=20501909; DOI=10.1105/tpc.110.075242;
RA   Li J.Y., Fu Y.L., Pike S.M., Bao J., Tian W., Zhang Y., Chen C.Z.,
RA   Zhang Y., Li H.M., Huang J., Li L.G., Schroeder J.I., Gassmann W.,
RA   Gong J.M.;
RT   "The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal
RT   from the xylem sap and mediates cadmium tolerance.";
RL   Plant Cell 22:1633-1646(2010).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=24055139; DOI=10.1016/j.tplants.2013.08.008;
RA   Leran S., Varala K., Boyer J.C., Chiurazzi M., Crawford N.,
RA   Daniel-Vedele F., David L., Dickstein R., Fernandez E., Forde B.,
RA   Gassmann W., Geiger D., Gojon A., Gong J.M., Halkier B.A., Harris J.M.,
RA   Hedrich R., Limami A.M., Rentsch D., Seo M., Tsay Y.F., Zhang M.,
RA   Coruzzi G., Lacombe B.;
RT   "A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family
RT   members in plants.";
RL   Trends Plant Sci. 19:5-9(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in shoots, roots, stems, leaves and
CC       flowers. {ECO:0000269|PubMed:17481610}.
CC   -!- INDUCTION: Down-regulated upon nematode infection.
CC       {ECO:0000269|PubMed:16478044}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC       {ECO:0000305}.
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DR   EMBL; AL391146; CAC01813.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92094.1; -; Genomic_DNA.
DR   EMBL; AK226765; BAE98864.1; -; mRNA.
DR   PIR; T51439; T51439.
DR   RefSeq; NP_196998.1; NM_121498.3.
DR   AlphaFoldDB; Q9LFR1; -.
DR   SMR; Q9LFR1; -.
DR   STRING; 3702.AT5G14940.1; -.
DR   PaxDb; Q9LFR1; -.
DR   PRIDE; Q9LFR1; -.
DR   EnsemblPlants; AT5G14940.1; AT5G14940.1; AT5G14940.
DR   GeneID; 831346; -.
DR   Gramene; AT5G14940.1; AT5G14940.1; AT5G14940.
DR   KEGG; ath:AT5G14940; -.
DR   Araport; AT5G14940; -.
DR   TAIR; locus:2147840; AT5G14940.
DR   eggNOG; KOG1237; Eukaryota.
DR   HOGENOM; CLU_009313_4_1_1; -.
DR   InParanoid; Q9LFR1; -.
DR   OMA; VCWIQIW; -.
DR   OrthoDB; 365203at2759; -.
DR   PhylomeDB; Q9LFR1; -.
DR   PRO; PR:Q9LFR1; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9LFR1; baseline and differential.
DR   Genevisible; Q9LFR1; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0071916; F:dipeptide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0042937; F:tripeptide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR   CDD; cd17417; MFS_NPF5; 1.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR044739; NRT1/PTR.
DR   InterPro; IPR000109; POT_fam.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..552
FT                   /note="Protein NRT1/ PTR FAMILY 5.8"
FT                   /id="PRO_0000399984"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        311..331
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        431..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         81
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q05085"
SQ   SEQUENCE   552 AA;  61732 MW;  5EB8C65F5201DD43 CRC64;
     MAGGEKRRGL SKSCALLIVI AGIERYAFKG VASNLVTYLT DVVKMSNSRA ATTVNTWSGF
     TFMLPLFSAP FADSYWDRFF TILASSSLYF VGLVGLTFTA FAGSRSTTKT ISLYFLYTSL
     SLVALGLGVL NPSLQAFGAD QLDYDLDHDN DHEPSSENKE VKSNRKTQFF QWWYFGVCAG
     SLLGVTVMAY IQDTFGWVIG FAIPTASMLL LIFLFLCGCG VYVYADPDLK AKPFQRILEI
     IKERVCGRNK ITLVNDHDLN AMELELQDQK PLCNCSNTEA NTTTKSLPDD HKSCKTGFSG
     LETVKLLLRL LPIWTMLLMF AVIFQQPATF FTKQGMTMKR NIGPNFKIPP ATLQSTITLS
     IILLMPFYDK ILIPIAKKLT KNEKGISVKE RMGIGMFLSI IAIVIAALVE RKRLKISKMM
     KTTPNLDPVS ILWLLPQYIL LGISDIFTVV GMQEFFYSEV PVSMRTMGFA LYTSVFGVGS
     FVSAALISII ETYTSSRGGK HNWFADDMSE ARLDNYYWLL AFTSAISFLM YIVICKHFKS
     RSDDDDQCDT NC
 
 
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