ID   PTRD1_MOUSE             Reviewed;         140 AA.
AC   D3Z4S3;
DT   27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Putative peptidyl-tRNA hydrolase PTRHD1;
DE            EC=3.1.1.29;
DE   AltName: Full=Peptidyl-tRNA hydrolase domain-containing protein 1;
GN   Name=Ptrhd1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-
CC         amino acid + H(+); Xref=Rhea:RHEA:54448, Rhea:RHEA-COMP:10123,
CC         Rhea:RHEA-COMP:13883, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:59874, ChEBI:CHEBI:78442, ChEBI:CHEBI:138191;
CC         EC=3.1.1.29;
CC   -!- SIMILARITY: Belongs to the PTH2 family. PTRHD1 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC162932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466623; EDL01370.1; -; Genomic_DNA.
DR   CCDS; CCDS56829.1; -.
DR   RefSeq; NP_001191841.1; NM_001204912.1.
DR   AlphaFoldDB; D3Z4S3; -.
DR   SMR; D3Z4S3; -.
DR   STRING; 10090.ENSMUSP00000137070; -.
DR   PhosphoSitePlus; D3Z4S3; -.
DR   EPD; D3Z4S3; -.
DR   MaxQB; D3Z4S3; -.
DR   PaxDb; D3Z4S3; -.
DR   PeptideAtlas; D3Z4S3; -.
DR   PRIDE; D3Z4S3; -.
DR   ProteomicsDB; 301919; -.
DR   Antibodypedia; 13171; 16 antibodies from 9 providers.
DR   Ensembl; ENSMUST00000179139; ENSMUSP00000137070; ENSMUSG00000096199.
DR   GeneID; 69709; -.
DR   KEGG; mmu:69709; -.
DR   UCSC; uc029rqo.1; mouse.
DR   CTD; 391356; -.
DR   MGI; MGI:1916959; Ptrhd1.
DR   VEuPathDB; HostDB:ENSMUSG00000096199; -.
DR   eggNOG; KOG3305; Eukaryota.
DR   GeneTree; ENSGT00500000044959; -.
DR   HOGENOM; CLU_119261_0_1_1; -.
DR   InParanoid; D3Z4S3; -.
DR   OMA; CLALKPC; -.
DR   OrthoDB; 1557083at2759; -.
DR   PhylomeDB; D3Z4S3; -.
DR   TreeFam; TF353726; -.
DR   BioGRID-ORCS; 69709; 2 hits in 70 CRISPR screens.
DR   ChiTaRS; Ptrhd1; mouse.
DR   PRO; PR:D3Z4S3; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; D3Z4S3; protein.
DR   Bgee; ENSMUSG00000096199; Expressed in internal carotid artery and 247 other tissues.
DR   Genevisible; D3Z4S3; MM.
DR   GO; GO:0004045; F:aminoacyl-tRNA hydrolase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1490.10; -; 1.
DR   InterPro; IPR023476; Pep_tRNA_hydro_II_dom_sf.
DR   InterPro; IPR002833; PTH2.
DR   InterPro; IPR042237; PTRHD1.
DR   PANTHER; PTHR46194; PTHR46194; 1.
DR   Pfam; PF01981; PTH2; 1.
DR   SUPFAM; SSF102462; SSF102462; 1.
PE   1: Evidence at protein level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..140
FT                   /note="Putative peptidyl-tRNA hydrolase PTRHD1"
FT                   /id="PRO_0000412069"
SQ   SEQUENCE   140 AA;  16037 MW;  ADD3F991F1B25C0E CRC64;
     MHRKVRPASL MIRKMACSGV EPQILVQYLV LRKDLSQAPF SWPTGALVAQ ACHAATAALH
     LHRDHPHTAA YLRELGRMRK VVLEAADETT LKELAETLQQ KNIDHTLWLE QPENIATCIA
     LRPYPKEEVS QYLKKFRLFK