ID   PTSN_KLEOX              Reviewed;         162 AA.
AC   P17162;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Nitrogen regulatory protein;
DE   AltName: Full=Enzyme IIA-NTR;
DE   Includes:
DE     RecName: Full=Phosphotransferase enzyme IIA component;
DE     AltName: Full=PTS system EIIA component;
GN   Name=ptsN;
OS   Klebsiella oxytoca.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=571;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M5a1;
RX   PubMed=2695747; DOI=10.1111/j.1365-2958.1989.tb00162.x;
RA   Merrick M.J., Coppard J.R.;
RT   "Mutations in genes downstream of the rpoN gene (encoding sigma 54) of
RT   Klebsiella pneumoniae affect expression from sigma 54-dependent
RT   promoters.";
RL   Mol. Microbiol. 3:1765-1775(1989).
CC   -!- FUNCTION: Seems to have a role in regulating nitrogen assimilation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- DOMAIN: The PTS EIIA type-2 domain may serve a regulatory function,
CC       through its phosphorylation activity.
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DR   EMBL; X16335; CAA34392.1; -; Genomic_DNA.
DR   PIR; S07661; S07661.
DR   RefSeq; WP_004125714.1; NZ_QPKC01000013.1.
DR   AlphaFoldDB; P17162; -.
DR   SMR; P17162; -.
DR   STRING; 571.MC52_05305; -.
DR   GeneID; 61287206; -.
DR   GeneID; 64335456; -.
DR   eggNOG; COG1762; Bacteria.
DR   OrthoDB; 1810962at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008982; F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity; IEA:InterPro.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00211; PTS_IIA_fru; 1.
DR   Gene3D; 3.40.930.10; -; 1.
DR   InterPro; IPR016152; PTrfase/Anion_transptr.
DR   InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR   InterPro; IPR006320; PTS_Nitro_regul.
DR   Pfam; PF00359; PTS_EIIA_2; 1.
DR   SUPFAM; SSF55804; SSF55804; 1.
DR   TIGRFAMs; TIGR01419; nitro_reg_IIA; 1.
DR   PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR   PROSITE; PS00372; PTS_EIIA_TYPE_2_HIS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Kinase; Transferase.
FT   CHAIN           1..162
FT                   /note="Nitrogen regulatory protein"
FT                   /id="PRO_0000186695"
FT   DOMAIN          12..156
FT                   /note="PTS EIIA type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00417"
FT   ACT_SITE        73
FT                   /note="Tele-phosphohistidine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00417"
SQ   SEQUENCE   162 AA;  17720 MW;  990737929D387B40 CRC64;
     MINNDSALQL SNVLNQECTR SQVHCQSKKR ALEIISELAA KQLGLSSQIV FEAILTREKM
     GSTGIGNGIA IPHGKLEEDT LRAVGVFVQL ETPIAFDAID NQPVDLLFAL LVPADQTKTH
     LHTLSLVAKR LADKTICRRL RAAQSDEELY EIITEAGSNN EA