ID   PTSO_KLEOX              Reviewed;          90 AA.
AC   P51185;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Phosphocarrier protein NPr;
DE   AltName: Full=Nitrogen-related HPr;
GN   Name=ptsO; Synonyms=npr;
OS   Klebsiella oxytoca.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=571;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M5a1;
RA   Merrick M.J., Taylor M.;
RT   "Sequence and characterisation of distal genes in the Klebsiella pneumoniae
RT   rpoN operon.";
RL   Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the phosphoenolpyruvate-dependent nitrogen-
CC       metabolic phosphotransferase system (nitrogen-metabolic PTS), that
CC       seems to be involved in regulating nitrogen metabolism. The phosphoryl
CC       group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl
CC       carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to
CC       EIIA-Ntr. Could function in the transcriptional regulation of sigma-54
CC       dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr
CC       (PtsN) proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the HPr family. {ECO:0000305}.
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DR   EMBL; Z50803; CAA90685.1; -; Genomic_DNA.
DR   PIR; S60667; S60667.
DR   AlphaFoldDB; P51185; -.
DR   SMR; P51185; -.
DR   STRING; 571.MC52_05315; -.
DR   eggNOG; COG1925; Bacteria.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   CDD; cd00367; PTS-HPr_like; 1.
DR   Gene3D; 3.30.1340.10; -; 1.
DR   InterPro; IPR000032; HPr-like.
DR   InterPro; IPR035895; HPr-like_sf.
DR   InterPro; IPR001020; PTS_HPr_His_P_site.
DR   InterPro; IPR002114; PTS_HPr_Ser_P_site.
DR   Pfam; PF00381; PTS-HPr; 1.
DR   PRINTS; PR00107; PHOSPHOCPHPR.
DR   SUPFAM; SSF55594; SSF55594; 1.
DR   TIGRFAMs; TIGR01003; PTS_HPr_family; 1.
DR   PROSITE; PS51350; PTS_HPR_DOM; 1.
DR   PROSITE; PS00369; PTS_HPR_HIS; 1.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphotransferase system.
FT   CHAIN           1..90
FT                   /note="Phosphocarrier protein NPr"
FT                   /id="PRO_0000107893"
FT   DOMAIN          2..90
FT                   /note="HPr"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
FT   ACT_SITE        16
FT                   /note="Pros-phosphohistidine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
SQ   SEQUENCE   90 AA;  9820 MW;  D5DBD7514B1149C6 CRC64;
     MTVKQTVEIS NKLGMHARPA MKLFELMQNY DAEVLLRNDE GTVAEANSVI ALLMLDSAKG
     RQIEIEANGP QEVEALAAVI ALFNAGFDED