PTSO_VIBCH
ID PTSO_VIBCH Reviewed; 92 AA.
AC Q9KP46;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Phosphocarrier protein NPr;
DE AltName: Full=Nitrogen-related HPr;
GN Name=npr; OrderedLocusNames=VC_2533;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Component of the phosphoenolpyruvate-dependent nitrogen-
CC metabolic phosphotransferase system (nitrogen-metabolic PTS), that
CC seems to be involved in regulating nitrogen metabolism. The phosphoryl
CC group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl
CC carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to
CC EIIA-Ntr. Could function in the transcriptional regulation of sigma-54
CC dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr
CC (PtsN) proteins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the HPr family. {ECO:0000305}.
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DR EMBL; AE003852; AAF95674.1; -; Genomic_DNA.
DR PIR; B82066; B82066.
DR RefSeq; NP_232161.1; NC_002505.1.
DR RefSeq; WP_001135899.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KP46; -.
DR SMR; Q9KP46; -.
DR STRING; 243277.VC_2533; -.
DR DNASU; 2615196; -.
DR EnsemblBacteria; AAF95674; AAF95674; VC_2533.
DR GeneID; 57990922; -.
DR GeneID; 66938578; -.
DR KEGG; vch:VC_2533; -.
DR PATRIC; fig|243277.26.peg.2412; -.
DR eggNOG; COG1925; Bacteria.
DR HOGENOM; CLU_136230_1_3_6; -.
DR OMA; SIMAMMM; -.
DR BioCyc; VCHO:VC2533-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd00367; PTS-HPr_like; 1.
DR Gene3D; 3.30.1340.10; -; 1.
DR InterPro; IPR000032; HPr-like.
DR InterPro; IPR035895; HPr-like_sf.
DR InterPro; IPR001020; PTS_HPr_His_P_site.
DR InterPro; IPR002114; PTS_HPr_Ser_P_site.
DR Pfam; PF00381; PTS-HPr; 1.
DR PRINTS; PR00107; PHOSPHOCPHPR.
DR SUPFAM; SSF55594; SSF55594; 1.
DR TIGRFAMs; TIGR01003; PTS_HPr_family; 1.
DR PROSITE; PS51350; PTS_HPR_DOM; 1.
DR PROSITE; PS00369; PTS_HPR_HIS; 1.
DR PROSITE; PS00589; PTS_HPR_SER; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphotransferase system; Reference proteome.
FT CHAIN 1..92
FT /note="Phosphocarrier protein NPr"
FT /id="PRO_0000107897"
FT DOMAIN 3..91
FT /note="HPr"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
FT ACT_SITE 17
FT /note="Pros-phosphohistidine intermediate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
SQ SEQUENCE 92 AA; 9910 MW; 0444411EB9C249CD CRC64;
MPQLSQTVLI QNRLGLHARA AVKLVQLAQS FDAVLTVQSQ DGREATADSV MGLLMLESAQ
GQNVVISAEG SQAEQALQAV CQLIEQKFDE DE