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PTSO_VIBCH
ID   PTSO_VIBCH              Reviewed;          92 AA.
AC   Q9KP46;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Phosphocarrier protein NPr;
DE   AltName: Full=Nitrogen-related HPr;
GN   Name=npr; OrderedLocusNames=VC_2533;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Component of the phosphoenolpyruvate-dependent nitrogen-
CC       metabolic phosphotransferase system (nitrogen-metabolic PTS), that
CC       seems to be involved in regulating nitrogen metabolism. The phosphoryl
CC       group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl
CC       carrier protein NPr by enzyme I-Ntr. Phospho-NPr then transfers it to
CC       EIIA-Ntr. Could function in the transcriptional regulation of sigma-54
CC       dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr
CC       (PtsN) proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the HPr family. {ECO:0000305}.
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DR   EMBL; AE003852; AAF95674.1; -; Genomic_DNA.
DR   PIR; B82066; B82066.
DR   RefSeq; NP_232161.1; NC_002505.1.
DR   RefSeq; WP_001135899.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KP46; -.
DR   SMR; Q9KP46; -.
DR   STRING; 243277.VC_2533; -.
DR   DNASU; 2615196; -.
DR   EnsemblBacteria; AAF95674; AAF95674; VC_2533.
DR   GeneID; 57990922; -.
DR   GeneID; 66938578; -.
DR   KEGG; vch:VC_2533; -.
DR   PATRIC; fig|243277.26.peg.2412; -.
DR   eggNOG; COG1925; Bacteria.
DR   HOGENOM; CLU_136230_1_3_6; -.
DR   OMA; SIMAMMM; -.
DR   BioCyc; VCHO:VC2533-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR   CDD; cd00367; PTS-HPr_like; 1.
DR   Gene3D; 3.30.1340.10; -; 1.
DR   InterPro; IPR000032; HPr-like.
DR   InterPro; IPR035895; HPr-like_sf.
DR   InterPro; IPR001020; PTS_HPr_His_P_site.
DR   InterPro; IPR002114; PTS_HPr_Ser_P_site.
DR   Pfam; PF00381; PTS-HPr; 1.
DR   PRINTS; PR00107; PHOSPHOCPHPR.
DR   SUPFAM; SSF55594; SSF55594; 1.
DR   TIGRFAMs; TIGR01003; PTS_HPr_family; 1.
DR   PROSITE; PS51350; PTS_HPR_DOM; 1.
DR   PROSITE; PS00369; PTS_HPR_HIS; 1.
DR   PROSITE; PS00589; PTS_HPR_SER; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Phosphotransferase system; Reference proteome.
FT   CHAIN           1..92
FT                   /note="Phosphocarrier protein NPr"
FT                   /id="PRO_0000107897"
FT   DOMAIN          3..91
FT                   /note="HPr"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
FT   ACT_SITE        17
FT                   /note="Pros-phosphohistidine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00681"
SQ   SEQUENCE   92 AA;  9910 MW;  0444411EB9C249CD CRC64;
     MPQLSQTVLI QNRLGLHARA AVKLVQLAQS FDAVLTVQSQ DGREATADSV MGLLMLESAQ
     GQNVVISAEG SQAEQALQAV CQLIEQKFDE DE
 
 
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