ID   PTSP_AGRIP              Reviewed;         251 AA.
AC   C0HKW7; C0HKW8; C0HKW9; C0HKX0; C0HKX1; C0HKX2;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Prothoracicostatic peptides {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Prothoracicostatic peptide 5 {ECO:0000303|PubMed:29466015};
DE              Short=PTSP-5 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Prothoracicostatic peptide 6 {ECO:0000303|PubMed:29466015};
DE              Short=PTSP-6 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Prothoracicostatic peptide 7 {ECO:0000303|PubMed:29466015};
DE              Short=PTSP-7 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Prothoracicostatic peptide precursor-related peptide 2 {ECO:0000303|PubMed:29466015};
DE              Short=PTSP-PP-2 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Prothoracicostatic peptide 8 {ECO:0000303|PubMed:29466015};
DE              Short=PTSP-8 {ECO:0000303|PubMed:29466015};
DE   Contains:
DE     RecName: Full=Prothoracicostatic peptide precursor-related peptide 3 {ECO:0000303|PubMed:29466015};
DE              Short=PTSP-PP-3 {ECO:0000303|PubMed:29466015};
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 190-198; 202-215; 218-228
RP   AND 232-251, TISSUE SPECIFICITY, MASS SPECTROMETRY, IDENTIFICATION BY MASS
RP   SPECTROMETRY, AND AMIDATION AT TRP-89; TRP-152; TRP-198 AND TRP-228.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Prothoracicostatic peptide 5: Expressed in antennal
CC       lobe (AL), corpora cardiaca (CC), corpora allata (CA) and gnathal
CC       ganglion (GNG) (at protein level). Expression in AL detected in all
CC       animals, in CC, CA and GNG in most (at protein level).
CC       Prothoracicostatic peptide 6: Expressed in antennal lobe (AL), corpora
CC       cardiaca (CC), corpora allata (CA) and gnathal ganglion (GNG) (at
CC       protein level). Expression in AL detected in all animals, expression in
CC       GNG in most animals, in CA and CC detected in some animals (at protein
CC       level). Prothoracicostatic peptide 7: Expressed in antennal lobe (AL),
CC       corpora cardiaca (CC), corpora allata (CA) and gnathal ganglion (GNG)
CC       (at protein level). Expression in AL, CA and CC detected in most
CC       animals, expression in GNG in some animals (at protein level).
CC       Prothoracicostatic peptide precursor-related peptide 2: Expressed in
CC       antennal lobe (AL), corpora cardiaca (CC) and corpora allata (CA) with
CC       expression detected in few animals (at protein level). Not expressed in
CC       gnathal ganglion (GNG) (at protein level). Prothoracicostatic peptide
CC       8: Expressed in antennal lobe (AL), corpora cardiaca (CC), corpora
CC       allata (CA) and gnathal ganglion (GNG) (at protein level). Expression
CC       in AL detected in all animals, expression in GNG in most animals, in CA
CC       and CC detected in some animals (at protein level). Prothoracicostatic
CC       peptide precursor-related peptide 3: Expressed in antennal lobe (AL) in
CC       few animals (at protein level). Not expressed in corpora cardiaca (CC),
CC       corpora allata (CA) and gnathal ganglion (GNG) (at protein level).
CC       {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: [Prothoracicostatic peptide 5]: Mass=1262.58;
CC       Method=MALDI; Note=Prothoracicostatic peptide 5.;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- MASS SPECTROMETRY: [Prothoracicostatic peptide 6]: Mass=1414.66;
CC       Method=MALDI; Note=Prothoracicostatic peptide 6.;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- MASS SPECTROMETRY: [Prothoracicostatic peptide 7]: Mass=997.47;
CC       Method=MALDI; Note=Prothoracicostatic peptide 7.;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- MASS SPECTROMETRY: [Prothoracicostatic peptide precursor-related
CC       peptide 2]: Mass=1690.78; Method=MALDI; Note=Prothoracicostatic
CC       peptide-PP 2.; Evidence={ECO:0000269|PubMed:29466015};
CC   -!- MASS SPECTROMETRY: [Prothoracicostatic peptide 8]: Mass=1359.67;
CC       Method=MALDI; Note=Prothoracicostatic peptide 8.;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- MASS SPECTROMETRY: [Prothoracicostatic peptide precursor-related
CC       peptide 3]: Mass=2072.80; Method=MALDI; Note=Prothoracicostatic
CC       peptide-PP 3.; Evidence={ECO:0000269|PubMed:29466015};
CC   -!- CAUTION: Further mature peptides might exist. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKW7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted.
FT   PROPEP          1..77
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444265"
FT   PEPTIDE         80..89
FT                   /note="Prothoracicostatic peptide 5"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444266"
FT   PROPEP          93..138
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444267"
FT   PEPTIDE         141..152
FT                   /note="Prothoracicostatic peptide 6"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444268"
FT   PROPEP          156..187
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444269"
FT   PEPTIDE         190..198
FT                   /note="Prothoracicostatic peptide 7"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444270"
FT   PEPTIDE         202..215
FT                   /note="Prothoracicostatic peptide precursor-related peptide
FT                   2"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444271"
FT   PEPTIDE         218..228
FT                   /note="Prothoracicostatic peptide 8"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444272"
FT   PEPTIDE         232..251
FT                   /note="Prothoracicostatic peptide precursor-related peptide
FT                   3"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444273"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          227..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         89
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT   MOD_RES         152
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT   MOD_RES         198
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT   MOD_RES         228
FT                   /note="Tryptophan amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
SQ   SEQUENCE   251 AA;  28633 MW;  F9B2C38ABD9AF02B CRC64;
     MRKSARGQVC TEAGAGASGD WQDMSSAWGK RAWQDLNSAW GKRGWNDMSS AWGKRAWQDL
     NSAWGKRGWQ DLNSAWGKRA WRDMSQSPWG KRGWNDMSSA WGKRGWNDMS SAWGKRGWND
     MSSAWGKRGW NDMSSAWGKR GPEKWANFHG SWGKRAAEPD YEEIDAAIEQ LIPIQQLSDN
     ERMEVPEKKA WSALHGAWGK RPVKQAQYNS GSYYWKREPA WTNLRGMWGK RSAPDADAVD
     DDHESSARDE A