ATP68_MOUSE
ID ATP68_MOUSE Reviewed; 58 AA.
AC P56379;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=ATP synthase subunit ATP5MJ, mitochondrial {ECO:0000305};
DE AltName: Full=6.8 kDa mitochondrial proteolipid protein;
DE Short=MLQ;
GN Name=Atp5mj; Synonyms=Atp5mpl {ECO:0000312|MGI:MGI:1917507}, Mp68;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC Complex V) produces ATP from ADP in the presence of a proton gradient
CC across the membrane which is generated by electron transport complexes
CC of the respiratory chain. F-type ATPases consist of two structural
CC domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC - containing the membrane proton channel, linked together by a central
CC stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC catalytic domain of F(1) is coupled via a rotary mechanism of the
CC central stalk subunits to proton translocation. Minor subunit required
CC to maintain the ATP synthase population in the mitochondria.
CC {ECO:0000250|UniProtKB:P56378}.
CC -!- SUBUNIT: Component of an ATP synthase complex composed of ATP5PB,
CC ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8,
CC ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ.
CC {ECO:0000250|UniProtKB:P14790}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:P56378}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the small mitochondrial proteolipid family.
CC {ECO:0000305}.
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DR EMBL; AK008333; BAB25610.1; -; mRNA.
DR EMBL; BC055712; AAH55712.1; -; mRNA.
DR EMBL; BC059719; AAH59719.1; -; mRNA.
DR CCDS; CCDS36566.1; -.
DR RefSeq; NP_081636.1; NM_027360.2.
DR RefSeq; XP_006516277.1; XM_006516214.3.
DR AlphaFoldDB; P56379; -.
DR SMR; P56379; -.
DR BioGRID; 213945; 3.
DR STRING; 10090.ENSMUSP00000021719; -.
DR iPTMnet; P56379; -.
DR PhosphoSitePlus; P56379; -.
DR EPD; P56379; -.
DR jPOST; P56379; -.
DR MaxQB; P56379; -.
DR PaxDb; P56379; -.
DR PeptideAtlas; P56379; -.
DR PRIDE; P56379; -.
DR ProteomicsDB; 285576; -.
DR TopDownProteomics; P56379; -.
DR Antibodypedia; 47448; 141 antibodies from 24 providers.
DR DNASU; 70257; -.
DR Ensembl; ENSMUST00000021719; ENSMUSP00000021719; ENSMUSG00000021290.
DR Ensembl; ENSMUST00000222874; ENSMUSP00000152618; ENSMUSG00000021290.
DR GeneID; 70257; -.
DR KEGG; mmu:70257; -.
DR UCSC; uc007pef.1; mouse.
DR CTD; 70257; -.
DR MGI; MGI:1917507; Atp5mpl.
DR VEuPathDB; HostDB:ENSMUSG00000021290; -.
DR eggNOG; ENOG502SVSA; Eukaryota.
DR GeneTree; ENSGT00390000016760; -.
DR HOGENOM; CLU_198465_0_0_1; -.
DR InParanoid; P56379; -.
DR OMA; RSDISHF; -.
DR OrthoDB; 1625753at2759; -.
DR PhylomeDB; P56379; -.
DR TreeFam; TF338412; -.
DR BioGRID-ORCS; 70257; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Atp5mpl; mouse.
DR PRO; PR:P56379; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; P56379; protein.
DR Bgee; ENSMUSG00000021290; Expressed in right kidney and 261 other tissues.
DR ExpressionAtlas; P56379; baseline and differential.
DR Genevisible; P56379; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR012574; ATP5MJ.
DR PANTHER; PTHR15233; PTHR15233; 1.
DR Pfam; PF08039; Mit_proteolip; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..58
FT /note="ATP synthase subunit ATP5MJ, mitochondrial"
FT /id="PRO_0000064394"
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 58 AA; 6698 MW; 29778A1393D38DCE CRC64;
MFQTLIQKVW VPMKPYYTQV YQEIWVGVGL MSLIVYKIRS ADKRSKALKG PAPAHGHH
