PTTG2_HUMAN
ID PTTG2_HUMAN Reviewed; 202 AA.
AC Q9NZH5; O95355; Q6NTC9; Q9UNJ6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Securin-2;
DE AltName: Full=Pituitary tumor-transforming gene 2 protein;
GN Name=PTTG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2), TISSUE SPECIFICITY, AND
RP VARIANT PRO-44.
RX PubMed=10084610; DOI=10.1210/jcem.84.3.5658;
RA Prezant T.R., Kadioglu P., Melmed S.;
RT "An intronless homolog of human proto-oncogene hPTTG is expressed in
RT pituitary tumors: evidence for hPTTG family.";
RL J. Clin. Endocrinol. Metab. 84:1149-1152(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP VARIANT PRO-44.
RX PubMed=10806349; DOI=10.1016/s0378-1119(00)00096-2;
RA Chen L., Puri R., Lefkowitz E.J., Kakar S.S.;
RT "Identification of the human pituitary tumor transforming gene (hPTTG)
RT family: molecular structure, expression, and chromosomal localization.";
RL Gene 248:41-50(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT PRO-44.
RC TISSUE=Pituitary adenoma;
RA Mu Y.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9NZH5-2; O95994: AGR2; NbExp=3; IntAct=EBI-17630019, EBI-712648;
CC Q9NZH5-2; P67870: CSNK2B; NbExp=3; IntAct=EBI-17630019, EBI-348169;
CC Q9NZH5-2; A0A0C4DGQ7: EML2; NbExp=3; IntAct=EBI-17630019, EBI-12112376;
CC Q9NZH5-2; P86480: PRR20D; NbExp=3; IntAct=EBI-17630019, EBI-12754095;
CC Q9NZH5-2; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-17630019, EBI-1504830;
CC Q9NZH5-2; Q0D2K3: RIPPLY1; NbExp=3; IntAct=EBI-17630019, EBI-10226430;
CC Q9NZH5-2; P51687: SUOX; NbExp=3; IntAct=EBI-17630019, EBI-3921347;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NZH5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NZH5-2; Sequence=VSP_031444;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in the pituitary, liver,
CC spleen, prostate, testis, ovary, small intestine and colon. Also
CC expressed in various pituitary, testicular, liver and ovarian tumors.
CC {ECO:0000269|PubMed:10084610, ECO:0000269|PubMed:10806349}.
CC -!- DOMAIN: The N-terminal destruction box (D-box) acts as a recognition
CC signal for degradation via the ubiquitin-proteasome pathway.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the securin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF116538; AAD41262.2; -; Genomic_DNA.
DR EMBL; AF200719; AAF72579.1; -; Genomic_DNA.
DR EMBL; AF095288; AAC64410.1; -; mRNA.
DR EMBL; AC021106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069114; AAH69114.1; -; mRNA.
DR EMBL; BC069400; AAH69400.1; -; mRNA.
DR CCDS; CCDS54755.1; -. [Q9NZH5-2]
DR RefSeq; NP_006598.2; NM_006607.2. [Q9NZH5-2]
DR AlphaFoldDB; Q9NZH5; -.
DR BioGRID; 115967; 14.
DR IntAct; Q9NZH5; 7.
DR STRING; 9606.ENSP00000424261; -.
DR iPTMnet; Q9NZH5; -.
DR PhosphoSitePlus; Q9NZH5; -.
DR BioMuta; PTTG2; -.
DR DMDM; 357529040; -.
DR EPD; Q9NZH5; -.
DR jPOST; Q9NZH5; -.
DR MassIVE; Q9NZH5; -.
DR MaxQB; Q9NZH5; -.
DR PaxDb; Q9NZH5; -.
DR PeptideAtlas; Q9NZH5; -.
DR PRIDE; Q9NZH5; -.
DR Antibodypedia; 43813; 131 antibodies from 18 providers.
DR DNASU; 10744; -.
DR Ensembl; ENST00000504686.2; ENSP00000424261.1; ENSG00000250254.2. [Q9NZH5-2]
DR GeneID; 10744; -.
DR KEGG; hsa:10744; -.
DR MANE-Select; ENST00000504686.2; ENSP00000424261.1; NM_006607.3; NP_006598.2. [Q9NZH5-2]
DR UCSC; uc011bye.3; human. [Q9NZH5-1]
DR CTD; 10744; -.
DR DisGeNET; 10744; -.
DR GeneCards; PTTG2; -.
DR HGNC; HGNC:9691; PTTG2.
DR HPA; ENSG00000250254; Low tissue specificity.
DR MIM; 604231; gene.
DR neXtProt; NX_Q9NZH5; -.
DR OpenTargets; ENSG00000250254; -.
DR PharmGKB; PA34035; -.
DR VEuPathDB; HostDB:ENSG00000250254; -.
DR eggNOG; ENOG502S2GG; Eukaryota.
DR GeneTree; ENSGT00390000009693; -.
DR HOGENOM; CLU_1363209_0_0_1; -.
DR InParanoid; Q9NZH5; -.
DR OMA; PWECNLL; -.
DR OrthoDB; 323342at2759; -.
DR TreeFam; TF330797; -.
DR PathwayCommons; Q9NZH5; -.
DR SignaLink; Q9NZH5; -.
DR SIGNOR; Q9NZH5; -.
DR BioGRID-ORCS; 10744; 36 hits in 1003 CRISPR screens.
DR GenomeRNAi; 10744; -.
DR Pharos; Q9NZH5; Tdark.
DR PRO; PR:Q9NZH5; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9NZH5; protein.
DR Bgee; ENSG00000250254; Expressed in oocyte and 99 other tissues.
DR Genevisible; Q9NZH5; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0051276; P:chromosome organization; IEA:InterPro.
DR GO; GO:0045143; P:homologous chromosome segregation; IBA:GO_Central.
DR GO; GO:2000816; P:negative regulation of mitotic sister chromatid separation; IBA:GO_Central.
DR InterPro; IPR006940; Securin_separation_inhibitor.
DR PANTHER; PTHR10418; PTHR10418; 1.
DR Pfam; PF04856; Securin; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Nucleus; Proto-oncogene;
KW Reference proteome; SH3-binding.
FT CHAIN 1..202
FT /note="Securin-2"
FT /id="PRO_0000319106"
FT REGION 60..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 61..64
FT /note="D-box"
FT /evidence="ECO:0000250"
FT MOTIF 163..173
FT /note="SH3-binding"
FT /evidence="ECO:0000250"
FT COMPBIAS 70..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 179..202
FT /note="LQSPSSILSTLDVELPAVCYDIDI -> FAVSFKHSVDPGC (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3"
FT /id="VSP_031444"
FT VARIANT 44
FT /note="R -> P (in dbSNP:rs6811863)"
FT /evidence="ECO:0000269|PubMed:10084610,
FT ECO:0000269|PubMed:10806349, ECO:0000269|Ref.3"
FT /id="VAR_038956"
SQ SEQUENCE 202 AA; 22302 MW; 3CBE738EC7817263 CRC64;
MATLIYVDKE IGEPGTRVAA KDVLKLESRP SIKALDGISQ VLTRRFGKTY DAPSALPKAT
RKALGTVNRA TEKSVKTNGP RKQKQPSFSA KKMTEKTVKT KSSVPASDDA YPEIEKFFPF
NLLDFESFDL PEERQIAHLP LSGVPLMILD EEGELEKLFQ LGPPSPVKMP SPPWECNLLQ
SPSSILSTLD VELPAVCYDI DI
